BRPI0301159B8 - solução protetora para prevenção de danos isquêmicos, e seu processo de preparação - Google Patents
solução protetora para prevenção de danos isquêmicos, e seu processo de preparaçãoInfo
- Publication number
- BRPI0301159B8 BRPI0301159B8 BRPI0301159A BR0301159A BRPI0301159B8 BR PI0301159 B8 BRPI0301159 B8 BR PI0301159B8 BR PI0301159 A BRPI0301159 A BR PI0301159A BR 0301159 A BR0301159 A BR 0301159A BR PI0301159 B8 BRPI0301159 B8 BR PI0301159B8
- Authority
- BR
- Brazil
- Prior art keywords
- ischemic damage
- protective solution
- preparation process
- preventing ischemic
- mosm
- Prior art date
Links
- 230000000302 ischemic effect Effects 0.000 title abstract 3
- 230000001681 protective effect Effects 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000007853 buffer solution Substances 0.000 abstract 1
- 238000005138 cryopreservation Methods 0.000 abstract 1
- 239000003792 electrolyte Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"solução protetora para prevenção de danos isquêmicos". a presente invenção refere-se a uma solução protetora para evitar danos isquêmicos em órgãos, ou em sistemas celulares isolados, ou partes de tecidos após perfusão, operação, transplante, ou crioconservação e em seguida reperfusão, que contém como eletrólitos íons alcalinos, opcionalmente também íons alcalino-terrosos, uma solução tampão, assim como poliol e/ou um açúcar, que apresenta uma osmolaridade de cerca de 290 mosm/l até cerca de 250 mosm/l, assim como um valor de ph de cerca de 6,8 até cerca de 7,4, e são adicionados o ácido hidroxâmico, e/ou um ou mais derivados de ácido hidroxâmico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10222561.3 | 2002-05-17 | ||
DE10222561A DE10222561B4 (de) | 2002-05-17 | 2002-05-17 | Protektive Lösung zur Verhinderung von Ischämieschäden |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0301159A BR0301159A (pt) | 2004-08-17 |
BRPI0301159B1 BRPI0301159B1 (pt) | 2018-05-15 |
BRPI0301159B8 true BRPI0301159B8 (pt) | 2021-05-25 |
Family
ID=29265373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0301159A BRPI0301159B8 (pt) | 2002-05-17 | 2003-05-16 | solução protetora para prevenção de danos isquêmicos, e seu processo de preparação |
Country Status (13)
Country | Link |
---|---|
US (2) | US7977383B2 (pt) |
EP (2) | EP1859679B1 (pt) |
JP (1) | JP4603246B2 (pt) |
KR (2) | KR101014990B1 (pt) |
CN (1) | CN100448440C (pt) |
AR (2) | AR039819A1 (pt) |
AT (2) | ATE503383T1 (pt) |
BR (1) | BRPI0301159B8 (pt) |
CA (1) | CA2429097C (pt) |
DE (4) | DE10262084B4 (pt) |
DK (1) | DK1859679T3 (pt) |
ES (2) | ES2362867T3 (pt) |
MX (1) | MXPA03004315A (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10262084B4 (de) | 2002-05-17 | 2009-12-24 | Dr. Franz Köhler Chemie GmbH | Protektive Lösung zur Verhinderung von Ischämieschäden |
AU2005247319B2 (en) | 2004-04-28 | 2011-12-01 | Molecules For Health, Inc. | Methods for treating or preventing restenosis and other vascular proliferative disorders |
US9237744B2 (en) * | 2004-05-26 | 2016-01-19 | National University Corporation Kagawa University | Preservative solution for cells, tissues and organs containing rare sugar and preservative method thereof |
DE102007026392A1 (de) | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Lösungen für die Perfusion und Konservierung von Organen und Geweben |
EP2030615A3 (en) * | 2007-08-13 | 2009-12-02 | ELFORD, Howard L. | Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases |
US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
JP5705324B2 (ja) * | 2010-09-01 | 2015-04-22 | パフュージョン・フルイド・テクノロジーズ・インコーポレイテッドPerfusion Fluid Technologies, Inc. | 灌流組成物 |
EP2694131B1 (en) | 2011-04-07 | 2019-08-28 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
BRPI1101935B1 (pt) * | 2011-04-15 | 2017-12-12 | Universidade Federal De Minas Gerais | Antioxidant composition for preservation of organs and fabrics |
DE102012005177A1 (de) | 2012-03-16 | 2013-09-19 | Bitop Ag | Organlagerlösung |
CN103238586B (zh) * | 2013-03-28 | 2014-03-26 | 辽宁亿灵科创生物医药科技有限公司 | 一种心肌脏器保存液制备方法 |
EP2821081A1 (en) * | 2013-07-05 | 2015-01-07 | ResuSciTec GmbH | Protective solution for preventing or reducing reperfusion injury of the brain and the whole body |
TWI734665B (zh) | 2013-12-24 | 2021-08-01 | 維吉尼亞聯邦大學 | 氧化膽固醇硫酸鹽(ocs)之用途 |
WO2017192413A1 (en) * | 2016-05-01 | 2017-11-09 | The Regents Of The University Of California | Glutarate compounds for treating ischemia-reperfusion injuries |
DE102016125414A1 (de) | 2016-12-22 | 2018-06-28 | Bitop Ag | Zusammensetzung enthaltend N-Acetyldiaminobuttersäure |
WO2019183793A1 (zh) * | 2018-03-27 | 2019-10-03 | 华东理工大学 | N-羟基吡啶酮类化合物及其用途 |
KR20200069995A (ko) | 2018-12-08 | 2020-06-17 | 이은지 | 접이식 빗자루 |
EP4248959A1 (en) * | 2022-03-22 | 2023-09-27 | Dr. Franz Köhler Chemie GmbH | Preparation for reduction of pathological iron overload |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH639270A5 (de) | 1978-12-14 | 1983-11-15 | Koehler Franz Dr Chemie Kg | Protektive loesung fuer herz und niere. |
DE3168925D1 (en) * | 1980-12-23 | 1985-03-28 | Koehler Chemie Dr Franz | Protective solution for heart and kidney, and manufacturing process |
US4419365A (en) | 1981-12-21 | 1983-12-06 | Ciba-Geigy Corporation | Method of treating Alzheimer's disease |
US4562006A (en) * | 1984-01-11 | 1985-12-31 | Warner-Lambert Company | Cycloheptadiene derivatives |
US4607053A (en) * | 1984-05-17 | 1986-08-19 | E. R. Squibb & Sons, Inc. | Arylhydroxamates useful as antiallergy agents |
US4604407A (en) * | 1985-04-04 | 1986-08-05 | E. R. Squibb & Sons, Inc. | Hydroxamates |
US4927571A (en) * | 1987-05-18 | 1990-05-22 | Liposome Technology, Inc. | Preparation of injectable doxorubicin/liposome suspension |
DK36389A (da) | 1988-02-05 | 1989-08-06 | Eastman Kodak Co | Praeparat og fremgangsmaade til at forebygge vaevskader ved reperfusion |
EP0523037A4 (en) | 1990-03-30 | 1993-07-28 | Biomedical Frontiers, Inc. | Fluid resuscitation |
JPH11514326A (ja) * | 1990-03-30 | 1999-12-07 | バイオメディカル フロンティアーズ インコーポレイテッド | 液体蘇生用医薬物 |
JP2768799B2 (ja) * | 1990-04-12 | 1998-06-25 | 株式会社大塚製薬工場 | 心筋保護液 |
CA2068333A1 (en) * | 1990-09-10 | 1992-03-11 | Austin L. Shug | Composition and method for protecting the heart during reperfusion |
JP2860301B2 (ja) * | 1990-09-19 | 1999-02-24 | ヘキスト・マリオン・ルセル株式会社 | 臓器保存用溶液 |
GB9024820D0 (en) * | 1990-11-15 | 1991-01-02 | Davies Michael J | Pharmaceutical compositions |
US5498427A (en) * | 1990-11-20 | 1996-03-12 | Pasteur Merieux Serums Et Vaccines | Solutions for the perfusion, preservation and reperfusion of organs |
US5290766A (en) * | 1991-02-18 | 1994-03-01 | The National Heart Foundation Of New Zealand | Cardioplegic compositions |
US5405742A (en) * | 1993-07-16 | 1995-04-11 | Cyromedical Sciences, Inc. | Solutions for tissue preservation and bloodless surgery and methods using same |
AU7560994A (en) * | 1993-08-12 | 1995-03-14 | University Of North Carolina At Chapel Hill, The | Rinse solution for organs and tissues |
US6321909B1 (en) * | 1997-02-13 | 2001-11-27 | Sky High, Llc | System for storing polyethylene glycol solutions |
EP0938896A1 (en) * | 1998-01-15 | 1999-09-01 | Novartis AG | Autoclavable pharmaceutical compositions containing a chelating agent |
US6365338B1 (en) * | 1999-04-27 | 2002-04-02 | David A. Bull | Organ preservative solution containing trehalose, anti-oxidant, cations and an energy source |
DE10262084B4 (de) | 2002-05-17 | 2009-12-24 | Dr. Franz Köhler Chemie GmbH | Protektive Lösung zur Verhinderung von Ischämieschäden |
-
2002
- 2002-05-17 DE DE10262084A patent/DE10262084B4/de not_active Expired - Fee Related
- 2002-05-17 DE DE10222561A patent/DE10222561B4/de not_active Expired - Fee Related
-
2003
- 2003-05-14 ES ES03010783T patent/ES2362867T3/es not_active Expired - Lifetime
- 2003-05-14 EP EP07012466A patent/EP1859679B1/de not_active Expired - Lifetime
- 2003-05-14 DE DE50313573T patent/DE50313573D1/de not_active Expired - Lifetime
- 2003-05-14 AT AT03010783T patent/ATE503383T1/de active
- 2003-05-14 AT AT07012466T patent/ATE446676T1/de active
- 2003-05-14 EP EP03010783A patent/EP1362511B1/de not_active Expired - Lifetime
- 2003-05-14 DE DE50312079T patent/DE50312079D1/de not_active Expired - Lifetime
- 2003-05-14 DK DK07012466.4T patent/DK1859679T3/da active
- 2003-05-14 ES ES07012466T patent/ES2335145T3/es not_active Expired - Lifetime
- 2003-05-16 AR ARP030101726A patent/AR039819A1/es not_active Application Discontinuation
- 2003-05-16 CN CNB031438474A patent/CN100448440C/zh not_active Expired - Lifetime
- 2003-05-16 JP JP2003138927A patent/JP4603246B2/ja not_active Expired - Fee Related
- 2003-05-16 US US10/438,977 patent/US7977383B2/en not_active Expired - Lifetime
- 2003-05-16 BR BRPI0301159A patent/BRPI0301159B8/pt not_active IP Right Cessation
- 2003-05-16 CA CA2429097A patent/CA2429097C/en not_active Expired - Lifetime
- 2003-05-16 MX MXPA03004315A patent/MXPA03004315A/es active IP Right Grant
- 2003-05-16 KR KR1020030031134A patent/KR101014990B1/ko active IP Right Grant
-
2010
- 2010-08-11 KR KR1020100077083A patent/KR101061293B1/ko active IP Right Grant
-
2011
- 2011-06-02 US US13/152,056 patent/US9603354B2/en not_active Expired - Lifetime
-
2014
- 2014-12-19 AR ARP140104816A patent/AR098880A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR0301159A (pt) | 2004-08-17 |
AR098880A2 (es) | 2016-06-22 |
DK1859679T3 (da) | 2010-03-15 |
AR039819A1 (es) | 2005-03-02 |
DE10222561B4 (de) | 2009-12-10 |
BRPI0301159B1 (pt) | 2018-05-15 |
CA2429097C (en) | 2013-06-18 |
JP2004002418A (ja) | 2004-01-08 |
US20110300237A1 (en) | 2011-12-08 |
ATE446676T1 (de) | 2009-11-15 |
EP1362511A1 (de) | 2003-11-19 |
EP1859679B1 (de) | 2009-10-28 |
US7977383B2 (en) | 2011-07-12 |
ATE503383T1 (de) | 2011-04-15 |
KR101014990B1 (ko) | 2011-02-16 |
DE50312079D1 (de) | 2009-12-10 |
EP1362511B1 (de) | 2011-03-30 |
KR20030089495A (ko) | 2003-11-21 |
EP1859679A1 (de) | 2007-11-28 |
KR20100093023A (ko) | 2010-08-24 |
DE10222561A1 (de) | 2003-12-04 |
DE10262084B4 (de) | 2009-12-24 |
JP4603246B2 (ja) | 2010-12-22 |
ES2362867T3 (es) | 2011-07-14 |
DE50313573D1 (de) | 2011-05-12 |
CN100448440C (zh) | 2009-01-07 |
CN1480132A (zh) | 2004-03-10 |
MXPA03004315A (es) | 2005-02-14 |
KR101061293B1 (ko) | 2011-08-31 |
US9603354B2 (en) | 2017-03-28 |
US20030215781A1 (en) | 2003-11-20 |
CA2429097A1 (en) | 2003-11-17 |
ES2335145T3 (es) | 2010-03-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B03H | Publication of an application: rectification [chapter 3.8 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: A01N 1/02 Ipc: A01N 1/02 (2006.01), A61K 31/16 (2006.01), A61K 31 |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/05/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 21A ANUIDADE. |