BRPI0113837B8 - compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreende - Google Patents
compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreendeInfo
- Publication number
- BRPI0113837B8 BRPI0113837B8 BRPI0113837A BRPI0113837B8 BR PI0113837 B8 BRPI0113837 B8 BR PI0113837B8 BR PI0113837 A BRPI0113837 A BR PI0113837A BR PI0113837 B8 BRPI0113837 B8 BR PI0113837B8
- Authority
- BR
- Brazil
- Prior art keywords
- mutilin
- compounds
- pharmaceutical composition
- hydrogen
- antimicrobial activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0022439A GB0022439D0 (en) | 2000-09-13 | 2000-09-13 | Organic compounds |
GB0022440A GB0022440D0 (en) | 2000-09-13 | 2000-09-13 | Organic Compounds |
GB0024674A GB0024674D0 (en) | 2000-10-09 | 2000-10-09 | Organic compounds |
PCT/EP2001/010502 WO2002022580A1 (en) | 2000-09-13 | 2001-09-11 | Antibacterials mutilins |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0113837A BR0113837A (pt) | 2003-06-03 |
BRPI0113837B1 BRPI0113837B1 (pt) | 2019-01-29 |
BRPI0113837B8 true BRPI0113837B8 (pt) | 2021-05-25 |
Family
ID=27255885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0113837 BRPI0113837B8 (pt) | 2000-09-13 | 2001-09-11 | compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreende |
Country Status (17)
Country | Link |
---|---|
US (3) | US7169804B2 (pt) |
EP (1) | EP1320525B1 (pt) |
JP (1) | JP5134181B2 (pt) |
CN (1) | CN1288134C (pt) |
AR (1) | AR030651A1 (pt) |
AT (1) | ATE264843T1 (pt) |
AU (1) | AU2001291854A1 (pt) |
BR (1) | BRPI0113837B8 (pt) |
CA (1) | CA2418538C (pt) |
DE (1) | DE60102936T2 (pt) |
ES (1) | ES2220809T3 (pt) |
HK (1) | HK1079506A1 (pt) |
MY (1) | MY133930A (pt) |
PE (1) | PE20020676A1 (pt) |
PT (1) | PT1320525E (pt) |
TW (1) | TWI306852B (pt) |
WO (1) | WO2002022580A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9918037D0 (en) * | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
GB0207495D0 (en) * | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
GB0209262D0 (en) | 2002-04-23 | 2002-06-05 | Biochemie Gmbh | Organic compounds |
RU2005105576A (ru) * | 2002-07-24 | 2005-10-10 | Сандоз АГ (CH) | Производные плевромутилина в качестве противомикроюных средств |
GB0308114D0 (en) * | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
US7544963B2 (en) * | 2005-04-29 | 2009-06-09 | Cree, Inc. | Binary group III-nitride based high electron mobility transistors |
GB0513058D0 (en) * | 2005-06-27 | 2005-08-03 | Sandoz Ag | Organic compounds |
WO2007037518A1 (ja) * | 2005-09-29 | 2007-04-05 | Dainippon Sumitomo Pharma Co., Ltd. | ムチリン誘導体及びそれを含有する医薬組成物 |
EP1808431A1 (en) * | 2006-01-16 | 2007-07-18 | Nabriva Therapeutics Forschungs GmbH | Mutilin derivatives and their use as pharmaceutical |
WO2007143507A2 (en) * | 2006-06-05 | 2007-12-13 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted erythromycin analogs |
EP1908750A1 (en) | 2006-10-05 | 2008-04-09 | Nabriva Therapeutics Forschungs GmbH | Process for the preparation of pleuromutilins |
WO2008143343A1 (ja) | 2007-05-24 | 2008-11-27 | Kyorin Pharmaceutical Co., Ltd. | 14位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
US20100184987A1 (en) * | 2008-11-13 | 2010-07-22 | Teva Pharmaceutical Industries Ltd. | Preparation of Retapamulin via its Pleuromutilin-thiol precursor |
CN103709115A (zh) * | 2012-10-09 | 2014-04-09 | 山东亨利医药科技有限责任公司 | 截短侧耳素类抗生素衍生物 |
TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE789629A (fr) * | 1971-10-05 | 1973-04-03 | Sandoz Sa | Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique |
DE2811314A1 (de) | 1978-03-16 | 1979-09-27 | Sandoz Ag | Kokzidiostatisches kombinationspraeparat |
DE2966635D1 (en) | 1979-01-12 | 1984-03-08 | Sandoz Ag | New pleuromutilin derivatives, their production and pharmaceutical compositions containing them |
JPS5594359A (en) * | 1979-01-12 | 1980-07-17 | Sandoz Ag | Novel pleuromutilin derivatives*their manufacture and use |
EP0153277B1 (de) * | 1984-02-17 | 1987-08-26 | Sandoz Ag | Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
JP3054875B2 (ja) * | 1995-02-13 | 2000-06-19 | 株式会社小松製作所 | プラズマトーチ |
EA199800525A1 (ru) | 1996-01-03 | 1999-02-25 | Смитклайн Бичем Пи-Эл-Си | Карбамоилоксипроизводные мутилина и их применение в качестве антибактериальных средств |
UY25225A1 (es) * | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
WO2000027790A1 (en) * | 1998-11-11 | 2000-05-18 | Smithkline Beecham P.L.C. | Mutilin compounds |
WO2000037074A1 (en) | 1998-12-18 | 2000-06-29 | Smithkline Beecham Plc | Mutilin 14-ester derivatives having antibacterial activity |
GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
GB0207495D0 (en) * | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
RU2005105576A (ru) * | 2002-07-24 | 2005-10-10 | Сандоз АГ (CH) | Производные плевромутилина в качестве противомикроюных средств |
-
2001
- 2001-09-10 PE PE2001000905A patent/PE20020676A1/es not_active Application Discontinuation
- 2001-09-11 US US10/363,840 patent/US7169804B2/en not_active Expired - Lifetime
- 2001-09-11 PT PT01972046T patent/PT1320525E/pt unknown
- 2001-09-11 AT AT01972046T patent/ATE264843T1/de active
- 2001-09-11 ES ES01972046T patent/ES2220809T3/es not_active Expired - Lifetime
- 2001-09-11 JP JP2002526833A patent/JP5134181B2/ja not_active Expired - Lifetime
- 2001-09-11 WO PCT/EP2001/010502 patent/WO2002022580A1/en active IP Right Grant
- 2001-09-11 TW TW090122488A patent/TWI306852B/zh not_active IP Right Cessation
- 2001-09-11 BR BRPI0113837 patent/BRPI0113837B8/pt not_active IP Right Cessation
- 2001-09-11 CA CA002418538A patent/CA2418538C/en not_active Expired - Lifetime
- 2001-09-11 DE DE60102936T patent/DE60102936T2/de not_active Expired - Lifetime
- 2001-09-11 AR ARP010104289A patent/AR030651A1/es not_active Application Discontinuation
- 2001-09-11 MY MYPI20014254 patent/MY133930A/en unknown
- 2001-09-11 CN CNB018155766A patent/CN1288134C/zh not_active Expired - Lifetime
- 2001-09-11 AU AU2001291854A patent/AU2001291854A1/en not_active Abandoned
- 2001-09-11 EP EP01972046A patent/EP1320525B1/en not_active Expired - Lifetime
-
2005
- 2005-12-12 HK HK05111385A patent/HK1079506A1/xx not_active IP Right Cessation
-
2007
- 2007-01-12 US US11/652,812 patent/US7569587B2/en not_active Expired - Lifetime
-
2009
- 2009-04-07 US US12/384,580 patent/US20090209584A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR0113837A (pt) | 2003-06-03 |
CN1288134C (zh) | 2006-12-06 |
US20040102482A1 (en) | 2004-05-27 |
US7169804B2 (en) | 2007-01-30 |
BRPI0113837B1 (pt) | 2019-01-29 |
US20090209584A1 (en) | 2009-08-20 |
CN1633415A (zh) | 2005-06-29 |
ATE264843T1 (de) | 2004-05-15 |
PE20020676A1 (es) | 2002-08-27 |
JP5134181B2 (ja) | 2013-01-30 |
ES2220809T3 (es) | 2004-12-16 |
EP1320525A1 (en) | 2003-06-25 |
JP2004509107A (ja) | 2004-03-25 |
MY133930A (en) | 2007-11-30 |
EP1320525B1 (en) | 2004-04-21 |
HK1079506A1 (en) | 2006-04-07 |
DE60102936T2 (de) | 2005-03-24 |
US7569587B2 (en) | 2009-08-04 |
WO2002022580A1 (en) | 2002-03-21 |
CA2418538A1 (en) | 2002-03-21 |
TWI306852B (en) | 2009-03-01 |
DE60102936D1 (de) | 2004-05-27 |
PT1320525E (pt) | 2004-09-30 |
US20070135483A1 (en) | 2007-06-14 |
AR030651A1 (es) | 2003-08-27 |
CA2418538C (en) | 2009-12-22 |
AU2001291854A1 (en) | 2002-03-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: BIOCHEMIE GMBH (AT) Free format text: NOME ALTERADO DE: BIOCHEMIE GESSELLSCHAFT M.B.H. |
|
B25D | Requested change of name of applicant approved |
Owner name: SANDOZ GMBH (AT) Free format text: NOME ALTERADO DE: BIOCHEMIE GMBH |
|
B25A | Requested transfer of rights approved |
Owner name: NABRIVA THERAPEUTICS AG (AT) Free format text: TRANSFERIDO DE: SANDOZ GMBH |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/01/2019, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/09/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 21A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2687 DE 05-07-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |