AR030651A1 - Antibacterianos - Google Patents
AntibacterianosInfo
- Publication number
- AR030651A1 AR030651A1 ARP010104289A ARP010104289A AR030651A1 AR 030651 A1 AR030651 A1 AR 030651A1 AR P010104289 A ARP010104289 A AR P010104289A AR P010104289 A ARP010104289 A AR P010104289A AR 030651 A1 AR030651 A1 AR 030651A1
- Authority
- AR
- Argentina
- Prior art keywords
- attached
- hydrogen
- alkyl
- oxygen
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Un compuesto de formula (1) en donde R y R2, junto con el átomo de nitrogeno con el que están unidos, forman pirrolidinilo o piperidinilo, R1 es un grupo de formula (2): -C(=X)-R9; R3 y R3' son hidrogeno, deuterio, o halogeno, R4, R5 y R10 son independientemente unos de otros, hidrogeno o alquilo, R6, R7 y R8 son hidrogeno o deuterio; R9 es amino, alquilo, arilo, heterociclilo o mercapto; y si X es oxígeno, R9 es adicionalmente hidrogeno; R'10 es alquilo, X es azufre, oxígeno, NR10, o N+(R'10)2, Y es azufre u oxígeno y m es 0, 1, o 2; con la condicion de que, cuando R y R2, junto con el átomo de nitrogeno con el que estén unidos, formen piperidinilo, m es 0 , Y es S, e Y está unido en la posicion 3 del anillo de piperidina, ese grupo de la formula (1) que está unido al anillo de piperidina por medio del residuo Y está en la configuracion (S) o en la configuracion (R) de preferencia en la configuracion (S), el cual es por ejemplo, util como antimicrobiano y antibacteriano.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0022439A GB0022439D0 (en) | 2000-09-13 | 2000-09-13 | Organic compounds |
GB0022440A GB0022440D0 (en) | 2000-09-13 | 2000-09-13 | Organic Compounds |
GB0024674A GB0024674D0 (en) | 2000-10-09 | 2000-10-09 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR030651A1 true AR030651A1 (es) | 2003-08-27 |
Family
ID=27255885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010104289A AR030651A1 (es) | 2000-09-13 | 2001-09-11 | Antibacterianos |
Country Status (17)
Country | Link |
---|---|
US (3) | US7169804B2 (es) |
EP (1) | EP1320525B1 (es) |
JP (1) | JP5134181B2 (es) |
CN (1) | CN1288134C (es) |
AR (1) | AR030651A1 (es) |
AT (1) | ATE264843T1 (es) |
AU (1) | AU2001291854A1 (es) |
BR (1) | BRPI0113837B8 (es) |
CA (1) | CA2418538C (es) |
DE (1) | DE60102936T2 (es) |
ES (1) | ES2220809T3 (es) |
HK (1) | HK1079506A1 (es) |
MY (1) | MY133930A (es) |
PE (1) | PE20020676A1 (es) |
PT (1) | PT1320525E (es) |
TW (1) | TWI306852B (es) |
WO (1) | WO2002022580A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9918037D0 (en) * | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
GB0207495D0 (en) * | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
GB0209262D0 (en) | 2002-04-23 | 2002-06-05 | Biochemie Gmbh | Organic compounds |
PL373460A1 (en) * | 2002-07-24 | 2005-08-22 | Sandoz Ag | Pleuromutilin derivatives as antimicrobbials |
GB0308114D0 (en) * | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
US7544963B2 (en) * | 2005-04-29 | 2009-06-09 | Cree, Inc. | Binary group III-nitride based high electron mobility transistors |
GB0513058D0 (en) * | 2005-06-27 | 2005-08-03 | Sandoz Ag | Organic compounds |
WO2007037518A1 (ja) * | 2005-09-29 | 2007-04-05 | Dainippon Sumitomo Pharma Co., Ltd. | ムチリン誘導体及びそれを含有する医薬組成物 |
EP1808431A1 (en) * | 2006-01-16 | 2007-07-18 | Nabriva Therapeutics Forschungs GmbH | Mutilin derivatives and their use as pharmaceutical |
CA2654450A1 (en) * | 2006-06-05 | 2007-12-13 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted erythromycin analogs |
EP1908750A1 (en) | 2006-10-05 | 2008-04-09 | Nabriva Therapeutics Forschungs GmbH | Process for the preparation of pleuromutilins |
US8222407B2 (en) | 2007-05-24 | 2012-07-17 | Kyorin Pharmaceutical Co., Ltd. | Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position |
US20100184987A1 (en) * | 2008-11-13 | 2010-07-22 | Teva Pharmaceutical Industries Ltd. | Preparation of Retapamulin via its Pleuromutilin-thiol precursor |
CN103709115A (zh) * | 2012-10-09 | 2014-04-09 | 山东亨利医药科技有限责任公司 | 截短侧耳素类抗生素衍生物 |
TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE789629A (fr) * | 1971-10-05 | 1973-04-03 | Sandoz Sa | Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique |
DE2811314A1 (de) | 1978-03-16 | 1979-09-27 | Sandoz Ag | Kokzidiostatisches kombinationspraeparat |
DE2966635D1 (en) | 1979-01-12 | 1984-03-08 | Sandoz Ag | New pleuromutilin derivatives, their production and pharmaceutical compositions containing them |
ZA80175B (en) * | 1979-01-12 | 1981-08-26 | Sandoz Ltd | New pleuromutilin derivatives, their production and use |
EP0153277B1 (de) | 1984-02-17 | 1987-08-26 | Sandoz Ag | Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
JP3054875B2 (ja) * | 1995-02-13 | 2000-06-19 | 株式会社小松製作所 | プラズマトーチ |
HUP9900973A3 (en) | 1996-01-03 | 2000-04-28 | Smithkline Beecham Plc | Carbamoyloxy derivatives of mutiline with antibacterial activity, pharmaceutical compns. contg. them and process for preparing the said compds. |
UY25225A1 (es) | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
WO2000027790A1 (en) | 1998-11-11 | 2000-05-18 | Smithkline Beecham P.L.C. | Mutilin compounds |
AU3036200A (en) | 1998-12-18 | 2000-07-12 | Smithkline Beecham Plc | Mutilin 14-ester derivatives having antibacterial activity |
GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
GB0207495D0 (en) * | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
PL373460A1 (en) * | 2002-07-24 | 2005-08-22 | Sandoz Ag | Pleuromutilin derivatives as antimicrobbials |
-
2001
- 2001-09-10 PE PE2001000905A patent/PE20020676A1/es not_active Application Discontinuation
- 2001-09-11 WO PCT/EP2001/010502 patent/WO2002022580A1/en active IP Right Grant
- 2001-09-11 DE DE60102936T patent/DE60102936T2/de not_active Expired - Lifetime
- 2001-09-11 TW TW090122488A patent/TWI306852B/zh not_active IP Right Cessation
- 2001-09-11 US US10/363,840 patent/US7169804B2/en not_active Expired - Lifetime
- 2001-09-11 PT PT01972046T patent/PT1320525E/pt unknown
- 2001-09-11 CA CA002418538A patent/CA2418538C/en not_active Expired - Lifetime
- 2001-09-11 BR BR0113837-5 patent/BRPI0113837B8/pt not_active IP Right Cessation
- 2001-09-11 AR ARP010104289A patent/AR030651A1/es not_active Application Discontinuation
- 2001-09-11 EP EP01972046A patent/EP1320525B1/en not_active Expired - Lifetime
- 2001-09-11 JP JP2002526833A patent/JP5134181B2/ja not_active Expired - Lifetime
- 2001-09-11 MY MYPI20014254 patent/MY133930A/en unknown
- 2001-09-11 CN CNB018155766A patent/CN1288134C/zh not_active Expired - Lifetime
- 2001-09-11 AT AT01972046T patent/ATE264843T1/de active
- 2001-09-11 AU AU2001291854A patent/AU2001291854A1/en not_active Abandoned
- 2001-09-11 ES ES01972046T patent/ES2220809T3/es not_active Expired - Lifetime
-
2005
- 2005-12-12 HK HK05111385A patent/HK1079506A1/xx not_active IP Right Cessation
-
2007
- 2007-01-12 US US11/652,812 patent/US7569587B2/en not_active Expired - Lifetime
-
2009
- 2009-04-07 US US12/384,580 patent/US20090209584A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2418538C (en) | 2009-12-22 |
DE60102936T2 (de) | 2005-03-24 |
US20040102482A1 (en) | 2004-05-27 |
PE20020676A1 (es) | 2002-08-27 |
DE60102936D1 (de) | 2004-05-27 |
AU2001291854A1 (en) | 2002-03-26 |
MY133930A (en) | 2007-11-30 |
EP1320525A1 (en) | 2003-06-25 |
ES2220809T3 (es) | 2004-12-16 |
TWI306852B (en) | 2009-03-01 |
US7169804B2 (en) | 2007-01-30 |
HK1079506A1 (en) | 2006-04-07 |
US20070135483A1 (en) | 2007-06-14 |
PT1320525E (pt) | 2004-09-30 |
JP2004509107A (ja) | 2004-03-25 |
WO2002022580A1 (en) | 2002-03-21 |
CN1288134C (zh) | 2006-12-06 |
CN1633415A (zh) | 2005-06-29 |
US20090209584A1 (en) | 2009-08-20 |
EP1320525B1 (en) | 2004-04-21 |
BRPI0113837B1 (pt) | 2019-01-29 |
BRPI0113837B8 (pt) | 2021-05-25 |
JP5134181B2 (ja) | 2013-01-30 |
BR0113837A (pt) | 2003-06-03 |
ATE264843T1 (de) | 2004-05-15 |
US7569587B2 (en) | 2009-08-04 |
CA2418538A1 (en) | 2002-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |