BRPI0112785B1 - polipeptídeo de fusão compreendendo um pró-domínio de miostatina, polinucleotídeo codificando o mesmo, micro-organismo compreendendo o referido polinucleotídeo, bem como método de identificação de uma porção de peptídeo funcional de um pró-domínio de miostatina - Google Patents

polipeptídeo de fusão compreendendo um pró-domínio de miostatina, polinucleotídeo codificando o mesmo, micro-organismo compreendendo o referido polinucleotídeo, bem como método de identificação de uma porção de peptídeo funcional de um pró-domínio de miostatina Download PDF

Info

Publication number
BRPI0112785B1
BRPI0112785B1 BRPI0112785A BR0112785A BRPI0112785B1 BR PI0112785 B1 BRPI0112785 B1 BR PI0112785B1 BR PI0112785 A BRPI0112785 A BR PI0112785A BR 0112785 A BR0112785 A BR 0112785A BR PI0112785 B1 BRPI0112785 B1 BR PI0112785B1
Authority
BR
Brazil
Prior art keywords
myostatin
peptide
gdf
pro
domain
Prior art date
Application number
BRPI0112785A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0112785A (pt
Inventor
Alexandra C Mcpherron
Se-Him Lee
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/628,112 external-priority patent/US7566768B1/en
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Publication of BR0112785A publication Critical patent/BR0112785A/pt
Publication of BRPI0112785B1 publication Critical patent/BRPI0112785B1/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1019Tetrapeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI0112785A 2000-07-27 2001-07-26 polipeptídeo de fusão compreendendo um pró-domínio de miostatina, polinucleotídeo codificando o mesmo, micro-organismo compreendendo o referido polinucleotídeo, bem como método de identificação de uma porção de peptídeo funcional de um pró-domínio de miostatina BRPI0112785B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/628,112 US7566768B1 (en) 1995-10-26 2000-07-27 Promyostatin peptides and methods of using same
PCT/US2001/023510 WO2002009641A2 (en) 2000-07-27 2001-07-26 Promyostatin peptides and methods of using same

Publications (2)

Publication Number Publication Date
BR0112785A BR0112785A (pt) 2003-07-01
BRPI0112785B1 true BRPI0112785B1 (pt) 2016-07-12

Family

ID=24517522

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0112785A BRPI0112785B1 (pt) 2000-07-27 2001-07-26 polipeptídeo de fusão compreendendo um pró-domínio de miostatina, polinucleotídeo codificando o mesmo, micro-organismo compreendendo o referido polinucleotídeo, bem como método de identificação de uma porção de peptídeo funcional de um pró-domínio de miostatina

Country Status (14)

Country Link
US (3) US7393682B1 (cg-RX-API-DMAC7.html)
EP (2) EP2360259A3 (cg-RX-API-DMAC7.html)
JP (1) JP5149478B2 (cg-RX-API-DMAC7.html)
CN (2) CN101261277B (cg-RX-API-DMAC7.html)
AR (1) AR030307A1 (cg-RX-API-DMAC7.html)
AU (2) AU8079901A (cg-RX-API-DMAC7.html)
BR (1) BRPI0112785B1 (cg-RX-API-DMAC7.html)
CA (1) CA2416260A1 (cg-RX-API-DMAC7.html)
IL (2) IL153970A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA03000786A (cg-RX-API-DMAC7.html)
NZ (2) NZ523672A (cg-RX-API-DMAC7.html)
PL (1) PL210158B1 (cg-RX-API-DMAC7.html)
WO (1) WO2002009641A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200300483B (cg-RX-API-DMAC7.html)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393682B1 (en) * 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US7566768B1 (en) 1995-10-26 2009-07-28 The Johns Hopkins University School Of Medicine Promyostatin peptides and methods of using same
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
JP4429728B2 (ja) 2002-02-21 2010-03-10 ワイス エルエルシー フォリスタチン(follistatin)ドメイン含有タンパク質
JP4429729B2 (ja) 2002-02-21 2010-03-10 ワイス エルエルシー Gasp1;フォリスタチンドメイン含有タンパク質
DE60331778D1 (de) 2002-09-16 2010-04-29 Univ Johns Hopkins Metalloproteaseaktivierung von myostatin und verfahren zur modulation der myostatinaktivität
AR047392A1 (es) 2002-10-22 2006-01-18 Wyeth Corp Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
EA009056B1 (ru) * 2002-12-20 2007-10-26 Амген, Инк. Связывающие агенты, ингибирующие миостатин
AU2013216655B2 (en) * 2002-12-20 2016-05-26 Amgen Inc. Binding agents which inhibit myostatin
US9068234B2 (en) * 2003-01-21 2015-06-30 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating gene expression
JP5110877B2 (ja) * 2003-06-02 2012-12-26 ワイス・エルエルシー 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン(gdf8)インヒビターの使用
ATE552272T1 (de) * 2004-09-30 2012-04-15 Orico Ltd Myostatin-isoform
CN101147068A (zh) * 2005-03-23 2008-03-19 惠氏公司 Gdf-8调节剂的检测
AU2006283725B2 (en) 2005-08-19 2012-02-16 The Trustees Of The University Of Pennsylvania Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8-associated disorders
KR101135220B1 (ko) 2005-10-06 2012-04-24 일라이 릴리 앤드 캄파니 항-마이오스타틴 항체
UA92504C2 (en) 2005-10-12 2010-11-10 Эли Лилли Энд Компани Anti-myostatin monoclonal antibody
MX2008007324A (es) * 2005-12-06 2009-03-04 Amgen Inc Usos de antagonistas de miostatina.
KR101463631B1 (ko) 2006-03-31 2014-11-19 추가이 세이야쿠 가부시키가이샤 항체의 혈중 동태를 제어하는 방법
JP2009545313A (ja) 2006-08-03 2009-12-24 オリコ・リミテッド ミオスタチンアンタゴニスト
BRPI0716249A2 (pt) * 2006-09-05 2013-09-03 Lilly Co Eli anticorpos antimiostatina
RU2510400C9 (ru) 2007-09-26 2014-07-20 Чугаи Сейяку Кабусики Кайся Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr
US20110111406A1 (en) 2008-04-11 2011-05-12 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
JP2012021973A (ja) * 2010-06-15 2012-02-02 Nitto Denko Corp Sprセンサセルおよびsprセンサ
WO2012073992A1 (ja) 2010-11-30 2012-06-07 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
EP2861617A1 (en) 2012-06-15 2015-04-22 Pfizer Inc. Improved antagonist antibodies against gdf-8 and uses therefor
TWI855488B (zh) 2012-08-24 2024-09-11 日商中外製藥股份有限公司 FcγRIIb特異性Fc區域變異體
JP6774164B2 (ja) 2012-08-24 2020-10-21 中外製薬株式会社 マウスFcγRII特異的Fc抗体
JP6346895B2 (ja) 2012-09-13 2018-06-20 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company ミオスタチンと結合するフィブロネクチンベースの足場ドメインタンパク質
US11267868B2 (en) 2013-04-02 2022-03-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
EP2983694B1 (en) 2013-04-08 2022-06-22 President and Fellows of Harvard College Compositions for rejuvenating skeletal muscle stem cells
EP2981822B1 (en) 2013-05-06 2020-09-02 Scholar Rock, Inc. Compositions and methods for growth factor modulation
WO2014201143A1 (en) 2013-06-11 2014-12-18 President And Fellows Of Harvard College Methods and compositions for increasing neurogenesis and angiogenesis
WO2016073906A2 (en) * 2014-11-06 2016-05-12 Scholar Rock, Inc. Transforming growth factor-related immunoassays
HK1243940A1 (zh) * 2014-11-06 2018-07-27 Scholar Rock, Inc. 抗原肌肉生长抑制素/潜在肌肉生长抑制素的抗体及其用途
AR103161A1 (es) 2014-12-19 2017-04-19 Chugai Pharmaceutical Co Ltd Anticuerpos antimiostatina y regiones fc variantes así como métodos de uso
TW202248212A (zh) 2015-02-05 2022-12-16 日商中外製藥股份有限公司 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途
CN113896789A (zh) * 2015-09-15 2022-01-07 供石公司 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其用途
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE
IL293766B2 (en) 2016-01-06 2023-08-01 Harvard College Treatment with gdf11 prevents weight gain, improves glucose loading and reduces hepatosteatosis
CN109071645A (zh) 2016-01-08 2018-12-21 供石公司 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法
IL301468A (en) 2016-06-13 2023-05-01 Scholar Rock Inc Use of myostatin inhibitors and combination therapies
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES
HRP20230308T1 (hr) 2017-01-06 2023-05-12 Scholar Rock, Inc. Liječenje metaboličkih bolesti putem inhibiranja aktivacije miostatina
CN111793123B (zh) * 2019-04-08 2022-03-08 中国农业大学 一种肌肉生长抑制素mstn的突变体及其应用
CN110192624A (zh) * 2019-07-05 2019-09-03 福建冠丰生物科技有限公司 一种海参牡蛎营养物口服含片及其制备方法
EP3839051A1 (en) * 2019-12-19 2021-06-23 Evonik Operations GmbH Method for the fermentative production of guanidinoacetic acid
CN116600824A (zh) 2020-07-10 2023-08-15 巴斯德研究所 Gdf11诊断和治疗焦虑症和抑郁症的用途
WO2024107652A1 (en) * 2022-11-14 2024-05-23 John Mansell Myostatin inhibition
AU2023413166A1 (en) 2022-12-22 2025-07-03 Scholar Rock, Inc. Selective and potent inhibitory antibodies of myostatin activation

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US732575A (en) * 1902-10-04 1903-06-30 Louis G Mayer Carriage-spring.
US4036945A (en) 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5206347A (en) 1985-08-06 1993-04-27 La Jolla Cancer Research Foundation Isolation and use of receptors binding to a peptide column
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5011912A (en) 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US5162215A (en) 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
ATE131872T1 (de) 1989-11-22 1996-01-15 Genentech Inc Latenz assoziierte peptide und deren verwendung
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
DE69030172T2 (de) 1990-01-26 1997-06-19 Immunomedics Inc Impfstoffe gegen Krebs und Infektionskrankheiten
WO1991012329A2 (en) 1990-02-12 1991-08-22 Board Of Regents, The University Of Texas System Satellite cell proliferation in adult skeletal muscle
US5265030A (en) 1990-04-24 1993-11-23 Scripps Clinic And Research Foundation System and method for determining three-dimensional structures of proteins
US5750342A (en) 1990-06-11 1998-05-12 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5314695A (en) 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
US5885794A (en) 1991-05-10 1999-03-23 The Salk Institute For Biological Studies Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily
AU2408292A (en) 1991-07-11 1993-02-11 Regents Of The University Of California, The A method to identify protein sequences that fold into a known three-dimensional structure
US5585479A (en) 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
JP3415643B2 (ja) 1992-12-04 2003-06-09 株式会社ミノファーゲン製薬 筋ジストロフィー症治療薬
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US6607884B1 (en) 1993-03-19 2003-08-19 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-8
US6465239B1 (en) * 1993-03-19 2002-10-15 The John Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
US7393682B1 (en) 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
ES2201076T3 (es) 1993-03-19 2004-03-16 The Johns Hopkins University School Of Medicine Factor-8 de diferenciacion del crecimiento.
US5994618A (en) 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
US20030074680A1 (en) 1993-03-19 2003-04-17 Johns Hopkins University School Of Medicine Growth differentiation factor-8
ES2213745T3 (es) * 1993-05-12 2004-09-01 Genetics Institute, Llc Composiciones de bmp-11.
US7332575B2 (en) 1994-03-18 2008-02-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
ATE305036T1 (de) 1994-07-08 2005-10-15 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-11
US5616561A (en) 1995-03-31 1997-04-01 Regents Of The University Of California TGF-β antagonists as mitigators of radiation-induced tissue damage
WO1996039535A1 (en) * 1995-06-06 1996-12-12 Jan Vijg Method of and apparatus for diagnostic dna testing
US5622699A (en) 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
DE19626982C1 (de) 1996-07-04 1997-09-25 Siemens Ag Elektromagnetisches Relais und Verfahren zu dessen Herstellung
US5776689A (en) 1996-07-19 1998-07-07 The Regents Of The University Of California Protein recruitment system
AU6274298A (en) 1997-02-05 1998-08-25 Johns Hopkins University School Of Medicine, The Growth differentiation factor-8
US5827533A (en) 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US5933819C1 (en) 1997-05-23 2001-11-13 Scripps Research Inst Prediction of relative binding motifs of biologically active peptides and peptide mimetics
US6103466A (en) * 1997-07-14 2000-08-15 University Of Liege Double-muscling in mammals
PT2045322E (pt) 1997-07-14 2015-10-16 Université de Liège Musculatura dupla em mamíferos
WO1999006559A1 (en) 1997-08-01 1999-02-11 The Johns Hopkins University School Of Medicine Methods to identify growth differentiation factor (gdf) receptors
US6696260B1 (en) 1997-08-01 2004-02-24 The Johns Hopkins University School Of Medicine Methods to identify growth differentiation factor (GDF) binding proteins
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US5885779A (en) 1997-09-09 1999-03-23 University Of British Columbia Repressed trans-activator system for characterization of protein-protein interactions
DE19800422A1 (de) 1998-01-08 1999-07-15 Bosch Gmbh Robert Bremsvorrichtung für Fahrzeuge
WO1999040181A1 (en) 1998-02-05 1999-08-12 The Johns Hopkins University School Of Medicine Growth differentiation factor-8
US6369201B1 (en) * 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6368597B1 (en) 1998-05-06 2002-04-09 Matamorphix, Inc. Methods of treating diabetes
DE60027135T2 (de) * 1999-01-21 2007-01-11 Metamorphix, Inc. Inhibitoren für wachstumdifferenzierungsfaktor und ihre anwendungen
KR100750695B1 (ko) * 1999-07-20 2007-08-22 파멕사 에이/에스 Gdf-8 활성을 하향-조절하는 방법

Also Published As

Publication number Publication date
US20090017522A1 (en) 2009-01-15
PL365780A1 (en) 2005-01-10
AU8079901A (en) 2002-02-13
MXPA03000786A (es) 2004-05-21
CN1449409A (zh) 2003-10-15
CN101261277A (zh) 2008-09-10
EP2360259A3 (en) 2011-11-16
IL153970A (en) 2012-08-30
EP1303534A4 (en) 2004-09-01
AU2001280799B2 (en) 2006-06-08
IL153970A0 (en) 2003-07-31
CA2416260A1 (en) 2002-02-07
CN101261277B (zh) 2014-03-12
EP1303534A2 (en) 2003-04-23
US7393682B1 (en) 2008-07-01
JP5149478B2 (ja) 2013-02-20
BR0112785A (pt) 2003-07-01
WO2002009641A2 (en) 2002-02-07
NZ523672A (en) 2006-02-24
US8323964B2 (en) 2012-12-04
PL210158B1 (pl) 2011-12-30
NZ542696A (en) 2008-02-29
WO2002009641A3 (en) 2002-05-10
CN100429225C (zh) 2008-10-29
ZA200300483B (en) 2004-02-19
US20110239317A1 (en) 2011-09-29
JP2004504826A (ja) 2004-02-19
AR030307A1 (es) 2003-08-20
EP2360259A2 (en) 2011-08-24
WO2002009641A9 (en) 2003-03-20

Similar Documents

Publication Publication Date Title
US8124830B2 (en) Transgenic non-human animals expressing a truncated activin type II receptor
US8323964B2 (en) Polynucleotides encoding promyostatin polypeptides
AU2001282999C1 (en) Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
AU2002307564A1 (en) Use of follistatin to increase muscle mass
AU2001282999A1 (en) Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
AU2001280799A1 (en) Promyostatin peptides and methods of using same
AU2011244851A1 (en) Promyostatin peptides and methods of using same
AU2012204098B2 (en) Use of follistatin to increase muscle mass
US7566768B1 (en) Promyostatin peptides and methods of using same
AU2007200633B2 (en) Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
AU2006209266A1 (en) Promyostatin peptides and methods of using same
HK1160723A (en) Use of follistatin to increase muscle mass
HK1161297A (en) Promyostatin peptides and methods of using same

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/07/2016, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)