BRPI0011449B8 - composição de antígeno compreendendo tetramiristoil cardiolipina e 1-palmitoil-2-oleil-sn-glicero-3-fosfocolina e método para detectar anticorpos anti-lipoidais em uma amostra humana biológica in vitro - Google Patents
composição de antígeno compreendendo tetramiristoil cardiolipina e 1-palmitoil-2-oleil-sn-glicero-3-fosfocolina e método para detectar anticorpos anti-lipoidais em uma amostra humana biológica in vitroInfo
- Publication number
- BRPI0011449B8 BRPI0011449B8 BRPI0011449A BR0011449A BRPI0011449B8 BR PI0011449 B8 BRPI0011449 B8 BR PI0011449B8 BR PI0011449 A BRPI0011449 A BR PI0011449A BR 0011449 A BR0011449 A BR 0011449A BR PI0011449 B8 BRPI0011449 B8 BR PI0011449B8
- Authority
- BR
- Brazil
- Prior art keywords
- antigen composition
- phosphocholine
- glycero
- palmitoyl
- oleyl
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 5
- 102000036639 antigens Human genes 0.000 title abstract 5
- 108091007433 antigens Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- UYWNJNXEHSUWLE-HFWGUVFESA-N [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoxy]propyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC UYWNJNXEHSUWLE-HFWGUVFESA-N 0.000 title 1
- 239000012472 biological sample Substances 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- SDCJNZZAOLRVCP-GTOSQJSUSA-N tetramyristoyl cardiolipin Chemical compound CCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCC)COP(O)(=O)OCC(O)COP(O)(=O)OC[C@H](OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC SDCJNZZAOLRVCP-GTOSQJSUSA-N 0.000 title 1
- 241000589884 Treponema pallidum Species 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 208000006379 syphilis Diseases 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/571—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses for venereal disease, e.g. syphilis, gonorrhoea
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13819299P | 1999-06-09 | 1999-06-09 | |
| PCT/US2000/015828 WO2000075666A1 (en) | 1999-06-09 | 2000-06-08 | Method for detecting syphilis using synthetic antigens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0011449A BR0011449A (pt) | 2002-03-19 |
| BR0011449B1 BR0011449B1 (pt) | 2013-12-03 |
| BRPI0011449B8 true BRPI0011449B8 (pt) | 2021-05-25 |
Family
ID=22480887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0011449A BRPI0011449B8 (pt) | 1999-06-09 | 2000-06-08 | composição de antígeno compreendendo tetramiristoil cardiolipina e 1-palmitoil-2-oleil-sn-glicero-3-fosfocolina e método para detectar anticorpos anti-lipoidais em uma amostra humana biológica in vitro |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1185872B1 (enExample) |
| JP (1) | JP4531314B2 (enExample) |
| CN (1) | CN1195986C (enExample) |
| AT (1) | ATE316245T1 (enExample) |
| AU (1) | AU771548B2 (enExample) |
| BR (1) | BRPI0011449B8 (enExample) |
| CA (1) | CA2375448C (enExample) |
| DE (1) | DE60025605T2 (enExample) |
| RU (1) | RU2244933C2 (enExample) |
| WO (1) | WO2000075666A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10250368A1 (de) * | 2002-10-29 | 2004-05-19 | Viramed Biotech Ag | Mittel und Verfahren zur Diagnose einer Treponemainfektion |
| RU2270450C1 (ru) * | 2004-08-20 | 2006-02-20 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия Министерства Здравоохранения Российской Федерации" | Способ диагностики сифилиса |
| US8148057B2 (en) | 2005-06-21 | 2012-04-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Methods, immunoassays and devices for detection of anti-lipoidal antibodies |
| AP2787A (en) | 2005-06-21 | 2013-10-31 | Us Gov Health & Human Serv | Methods, immunoassays and devices for detection ofanti-lipoidal antibodies |
| WO2007061793A2 (en) * | 2005-11-18 | 2007-05-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SCIENCES, CENTERS FOR DISEASE CONTROL AND PREVENTION | Modified cardiolipin and uses therefor |
| US8778619B2 (en) | 2005-11-18 | 2014-07-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oxidized cardiolipin and uses to detect cardiolipin antibodies |
| JP4629563B2 (ja) * | 2005-12-07 | 2011-02-09 | 積水メディカル株式会社 | 抗リン脂質抗体測定試薬 |
| WO2007066731A1 (ja) * | 2005-12-07 | 2007-06-14 | Sekisui Medical Co., Ltd. | 抗リン脂質抗体測定試薬及び抗トレポネーマ・パリダム抗体測定試薬 |
| RU2327170C2 (ru) * | 2006-02-27 | 2008-06-20 | Закрытое акционерное общество "ДиТест" | Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса |
| RU2394496C1 (ru) * | 2009-03-11 | 2010-07-20 | Федеральное Государственное Учреждение "Государственный Научный Центр Дерматовенерологии Федерального Агентства По Высокотехнологичной Медицинской Помощи" | Способ диагностики сифилиса путем одновременного определения реагиновых и трепонемоспецифических антител к t.pallidum на микроскопных альдегидных слайдах |
| RU2421730C1 (ru) * | 2010-04-09 | 2011-06-20 | Государственное образовательное учреждение высшего профессионального образования "Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого Министерства здравоохранения и социального развития Российской Федерации" | Способ диагностики раннего врожденного сифилиса скрытого |
| CN102095861A (zh) * | 2011-01-25 | 2011-06-15 | 厦门大学附属中山医院 | 梅毒特异性总抗体和心磷脂抗体免疫印迹试剂盒及其制备 |
| RU2474820C2 (ru) * | 2011-04-11 | 2013-02-10 | Виктория Олеговна Пожарская | Способ контроля эффективности лечения сифилиса |
| US8945827B2 (en) | 2013-03-13 | 2015-02-03 | Awareness Technology, Inc. | Serological methods and diagnostic tests for syphilis antibodies |
| CN104049081B (zh) * | 2013-03-13 | 2016-03-09 | 意识科技股份有限公司 | 针对梅毒抗体的血清学方法和诊断测试 |
| GB201400819D0 (en) * | 2014-01-17 | 2014-03-05 | Sec Dep For Health The | Mycobacterial antigen composition |
| CN107533060B (zh) * | 2015-03-10 | 2019-11-05 | 生物辐射实验室股份有限公司 | 组合密螺旋体和非密螺旋体梅毒测试 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1053504A (enExample) * | 1964-03-17 | 1967-01-04 | ||
| EP0009088A1 (de) * | 1978-09-18 | 1980-04-02 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Reagenz zur Bestimmung von Wassermann-Antikörpern, Verfahren zu dessen Herstellung, Anwendung und Verwendung dieses Reagenzes zur Bestimmung von Wassermann-Antikörpern sowie entsprechende Reagenziengarnitur |
-
2000
- 2000-06-08 DE DE60025605T patent/DE60025605T2/de not_active Expired - Lifetime
- 2000-06-08 CN CNB008085404A patent/CN1195986C/zh not_active Expired - Lifetime
- 2000-06-08 JP JP2001501890A patent/JP4531314B2/ja not_active Expired - Lifetime
- 2000-06-08 WO PCT/US2000/015828 patent/WO2000075666A1/en not_active Ceased
- 2000-06-08 EP EP00939708A patent/EP1185872B1/en not_active Expired - Lifetime
- 2000-06-08 CA CA002375448A patent/CA2375448C/en not_active Expired - Lifetime
- 2000-06-08 BR BRPI0011449A patent/BRPI0011449B8/pt not_active IP Right Cessation
- 2000-06-08 AT AT00939708T patent/ATE316245T1/de active
- 2000-06-08 RU RU2001135795/15A patent/RU2244933C2/ru active
- 2000-06-08 AU AU54756/00A patent/AU771548B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE60025605D1 (de) | 2006-04-06 |
| BR0011449B1 (pt) | 2013-12-03 |
| EP1185872B1 (en) | 2006-01-18 |
| RU2244933C2 (ru) | 2005-01-20 |
| AU5475600A (en) | 2000-12-28 |
| CN1195986C (zh) | 2005-04-06 |
| ATE316245T1 (de) | 2006-02-15 |
| CN1353815A (zh) | 2002-06-12 |
| CA2375448C (en) | 2009-04-07 |
| WO2000075666A1 (en) | 2000-12-14 |
| DE60025605T2 (de) | 2006-11-09 |
| JP2003501662A (ja) | 2003-01-14 |
| AU771548B2 (en) | 2004-03-25 |
| CA2375448A1 (en) | 2000-12-14 |
| EP1185872A1 (en) | 2002-03-13 |
| JP4531314B2 (ja) | 2010-08-25 |
| BR0011449A (pt) | 2002-03-19 |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/12/2013, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/06/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 08/06/2020 |