BR9915139A - Método de inibir a hiperpermeabilidade vascular, e de inibir um processo ou estado fisiológico em um indivìduo - Google Patents

Método de inibir a hiperpermeabilidade vascular, e de inibir um processo ou estado fisiológico em um indivìduo

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Publication number
BR9915139A
BR9915139A BR9915139-1A BR9915139A BR9915139A BR 9915139 A BR9915139 A BR 9915139A BR 9915139 A BR9915139 A BR 9915139A BR 9915139 A BR9915139 A BR 9915139A
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BR
Brazil
Prior art keywords
inhibiting
tyrosine kinase
vascular hyperpermeability
individual
events
Prior art date
Application number
BR9915139-1A
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English (en)
Inventor
Lee D Arnold
Peter F Bousquet
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR9915139A publication Critical patent/BR9915139A/pt

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    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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Abstract

"MéTODO DE INIBIR A HIPERPERMEABILIDADE VASCULAR, E DE INIBIR UM PROCESSO OU ESTADO FISIOLóGICO EM UM INDIVìDUO" A hiperpermeabilidade vascular em indivíduos é um prelúdio para diversos eventos fisiológicos que são freq³entemente nocivos. Entre estes eventos está a formação de edema, diapedese, mudança transendotelial aberrante, extravasação, exsudação e efusão, deposição de matriz (freq³entemente com a proliferação estromal anormal) e hipotensão vascular. A hiperpermeabilidade vascular e os eventos subsequentes podem ser inibidos pela administração de um composto que inibe a atividade da enzima do receptor de tirosina cinase de VEGF conhecido como receptor de tirosina cinase de KDR. Os compostos administrados preferidos inibem seletivamente a função da tirosina cinase KDR mas não bloqueiam a atividade da tirosina cinase de Flt-1 que é um outro receptor de tirosina cinase de VEGF.
BR9915139-1A 1998-11-06 1999-11-03 Método de inibir a hiperpermeabilidade vascular, e de inibir um processo ou estado fisiológico em um indivìduo BR9915139A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10746298P 1998-11-06 1998-11-06
PCT/US1999/025903 WO2000027414A2 (en) 1998-11-06 1999-11-03 Inhibition of the formation of vascular hyperpermeability

Publications (1)

Publication Number Publication Date
BR9915139A true BR9915139A (pt) 2001-08-07

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ID=22316735

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BR9915139-1A BR9915139A (pt) 1998-11-06 1999-11-03 Método de inibir a hiperpermeabilidade vascular, e de inibir um processo ou estado fisiológico em um indivìduo

Country Status (19)

Country Link
EP (1) EP1126842A2 (pt)
JP (1) JP2002529421A (pt)
KR (1) KR20010080952A (pt)
CN (1) CN1342077A (pt)
AR (1) AR023912A1 (pt)
AU (1) AU1908000A (pt)
BG (1) BG105476A (pt)
BR (1) BR9915139A (pt)
CA (1) CA2347916A1 (pt)
CO (1) CO5150183A1 (pt)
CZ (1) CZ20011564A3 (pt)
HU (1) HUP0104302A3 (pt)
ID (1) ID29063A (pt)
IL (1) IL142583A0 (pt)
NO (1) NO20012218L (pt)
PL (1) PL348163A1 (pt)
SK (1) SK5052001A3 (pt)
TR (1) TR200102278T2 (pt)
WO (1) WO2000027414A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2016953A3 (en) * 1998-12-22 2009-04-15 Genentech, Inc. Vascular endothelial cell growth factor antagonists and uses thereof
CA2359244C (en) 1999-01-13 2013-10-08 Bayer Corporation .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
RU2271216C2 (ru) * 1999-12-22 2006-03-10 Дзе Скриппс Рисерч Инститьют Модуляторы ангиогенеза и проницаемости сосудов
DE10021246A1 (de) * 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
US20040242545A1 (en) * 2001-07-26 2004-12-02 Santen Phamaceutical Co., Ltd. Remedy for glaucoma comprising as the active ingredient compound having p13 kinase inhibitory effect
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
WO2006006948A2 (en) 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
DK2284266T3 (da) * 2002-11-14 2014-01-13 Thermo Fisher Scient Biosciences Inc sIRNA-MOLEKYLE MOD TP53
DK2284180T3 (en) 2003-03-03 2015-12-21 Dyax Corp Uses of peptides that specifically bind to the HGF receptor (cMET)
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
ES2297490T3 (es) 2003-07-23 2008-05-01 Bayer Pharmaceuticals Corporation Omega-carboxiarildifenilurea fluoro sustituida para el tratamiento y prevencion de enfermadades y afecciones.
US8247384B2 (en) * 2006-11-15 2012-08-21 Coda Therapeutics, Inc. Methods and compositions for wound healing
WO2012015775A2 (en) 2010-07-28 2012-02-02 Dharmacon, Inc. Sirna targeting vegfa and methods for treatment in vivo
KR101565886B1 (ko) 2013-10-23 2015-11-05 전남대학교산학협력단 난소과자극증후군의 진단 방법 및 키트
CN114010788A (zh) 2014-08-22 2022-02-08 奥克兰联合服务有限公司 通道调节剂
CN106381330A (zh) * 2016-08-30 2017-02-08 张建华 一种检测交通性脑积水易感性的引物及试剂盒
KR102644938B1 (ko) * 2018-03-19 2024-03-07 주식회사 파멥신 항-vegfr-2 항체
CN109718253B (zh) * 2019-01-16 2021-09-24 中国人民解放军总医院 一种代谢产生组胺的菌在预防或治疗高原病中的用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789948A (fr) * 1971-10-13 1973-04-11 Sandoz Sa Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
US3843664A (en) * 1973-02-20 1974-10-22 Sandoz Ag Substituted naphtho pyrazoles
US3843665A (en) * 1973-04-11 1974-10-22 Sandoz Ag Process for preparing substituted indeno,naphtho and cyclohepta pyrazoles
US3843666A (en) * 1973-05-29 1974-10-22 Sandoz Ag Process for preparing substituted indeno,naphtho and cyclohepta pyrazoles
US5712395A (en) * 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
WO1998033917A1 (en) * 1994-11-14 1998-08-06 The Ludwig Institute For Cancer Research Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof
US6346398B1 (en) * 1995-10-26 2002-02-12 Ribozyme Pharmaceuticals, Inc. Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor
FR2742662B1 (fr) * 1995-12-21 1998-01-23 Centre Nat Rech Scient Anticorps anti-idiotypiques du facteur de croissance endotheliale vasculaire et leur utilisation comme medicaments
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
DE19638745C2 (de) * 1996-09-11 2001-05-10 Schering Ag Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR)
ATE371727T1 (de) * 1997-06-18 2007-09-15 Merck & Co Inc Kdr, ein menschlicher tyrosin kinase rezeptor
JP2001518501A (ja) * 1997-10-06 2001-10-16 ビーエーエスエフ アクチェンゲゼルシャフト インデノ[1,2−c]−、ナフト[1,2−c]−およびベンゾ[6,7]シクロへプタ[1,2−c]ピラゾール誘導体
CN1278724A (zh) * 1997-10-06 2001-01-03 巴斯福股份公司 抑制酪氨酸激酶活性的茚并[1,2-c]吡唑衍生物
DE69918542T2 (de) * 1998-04-30 2005-08-18 Abbott Gmbh & Co. Kg Substituierte trizyklische pyrazolderivate mit protein kinase aktivität

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AU1908000A (en) 2000-05-29
KR20010080952A (ko) 2001-08-25
EP1126842A2 (en) 2001-08-29
NO20012218L (no) 2001-06-18
CO5150183A1 (es) 2002-04-29
HUP0104302A2 (hu) 2002-03-28
TR200102278T2 (tr) 2001-12-21
WO2000027414A3 (en) 2000-09-08
CN1342077A (zh) 2002-03-27
CA2347916A1 (en) 2000-05-18
WO2000027414A2 (en) 2000-05-18
JP2002529421A (ja) 2002-09-10
AR023912A1 (es) 2002-09-04
BG105476A (en) 2002-02-28
SK5052001A3 (en) 2002-10-08
NO20012218D0 (no) 2001-05-04
CZ20011564A3 (cs) 2002-04-17
IL142583A0 (en) 2002-03-10
PL348163A1 (en) 2002-05-06
ID29063A (id) 2001-07-26
HUP0104302A3 (en) 2002-11-28

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