BR9914655A - Processo para preparar (+) -eixo-6-fenil-3-azabiciclo-[3,2,0]heptanos, e, ditoluoiltartarato - Google Patents
Processo para preparar (+) -eixo-6-fenil-3-azabiciclo-[3,2,0]heptanos, e, ditoluoiltartaratoInfo
- Publication number
- BR9914655A BR9914655A BR9914655-0A BR9914655A BR9914655A BR 9914655 A BR9914655 A BR 9914655A BR 9914655 A BR9914655 A BR 9914655A BR 9914655 A BR9914655 A BR 9914655A
- Authority
- BR
- Brazil
- Prior art keywords
- phenyl
- heptanes
- azabicyclo
- exo
- ditoluoiltartarate
- Prior art date
Links
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical class CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- WMJNKBXKYHXOHC-UHFFFAOYSA-N 2,3-dihydroxy-2,3-bis(2-methylbenzoyl)butanedioic acid Chemical compound CC1=CC=CC=C1C(=O)C(O)(C(O)=O)C(O)(C(O)=O)C(=O)C1=CC=CC=C1C WMJNKBXKYHXOHC-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCESSO PARA PREPARAR (+)-EXO-6-FENIL-3-AZABICICLO-[3,2,0]HEPTANOS, E, DITOLUOILTARTARATO" Processo para preparação de (+)-exo-6-fenil-3-azabiciclo-[3,2,0]heptanos da fórmula I em que R é hidrogênio, cloro, bromo, flúor ou metoxi, o qual compreende a fotociclização de sal bisalilamónio da fórmula II em que R tem os significados dados acima e X^ -^ é um ânion, em um solvente inerte em uma aparelhagem de vidro com adição de sensibilizador e precipitação usando ácido (-)-ditoluoiltartárico o desejado (+)-exo-isómero I como ditoluoiltartarato proveniente da mistura resultante, com ou sem recristalização deste tartarato da mistura álcool/água.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19848521A DE19848521A1 (de) | 1998-10-21 | 1998-10-21 | Verfahren zur Herstellung von (+)-exo-6-Phenyl-3-azabicyclo-[3.2.0]heptanen |
PCT/EP1999/007682 WO2000023423A1 (de) | 1998-10-21 | 1999-10-13 | Verfahren zur herstellung von (+)-exo-6-phenyl-3-azabicyclo-[3.2.0]heptanen |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914655A true BR9914655A (pt) | 2001-07-03 |
Family
ID=7885183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914655-0A BR9914655A (pt) | 1998-10-21 | 1999-10-13 | Processo para preparar (+) -eixo-6-fenil-3-azabiciclo-[3,2,0]heptanos, e, ditoluoiltartarato |
Country Status (16)
Country | Link |
---|---|
US (1) | US6328855B1 (pt) |
EP (1) | EP1123278B1 (pt) |
JP (1) | JP3842044B2 (pt) |
KR (1) | KR20010075647A (pt) |
CN (1) | CN1324346A (pt) |
AT (1) | ATE330942T1 (pt) |
AU (1) | AU765446B2 (pt) |
BR (1) | BR9914655A (pt) |
CA (1) | CA2347757C (pt) |
CZ (1) | CZ20011422A3 (pt) |
DE (2) | DE19848521A1 (pt) |
HK (1) | HK1040251A1 (pt) |
HU (1) | HUP0104127A2 (pt) |
IL (1) | IL142585A0 (pt) |
NO (1) | NO20011822L (pt) |
WO (1) | WO2000023423A1 (pt) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4243287A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
DE4427648A1 (de) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituierte 3-Azabicyclo[3,2,0,]heptan-Derivate, ihre Herstellung und Verwendung |
DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
-
1998
- 1998-10-21 DE DE19848521A patent/DE19848521A1/de not_active Ceased
-
1999
- 1999-10-13 CZ CZ20011422A patent/CZ20011422A3/cs unknown
- 1999-10-13 HU HU0104127A patent/HUP0104127A2/hu unknown
- 1999-10-13 BR BR9914655-0A patent/BR9914655A/pt not_active IP Right Cessation
- 1999-10-13 IL IL14258599A patent/IL142585A0/xx unknown
- 1999-10-13 CA CA002347757A patent/CA2347757C/en not_active Expired - Fee Related
- 1999-10-13 CN CN99812430A patent/CN1324346A/zh active Pending
- 1999-10-13 EP EP99953799A patent/EP1123278B1/de not_active Expired - Lifetime
- 1999-10-13 KR KR1020017004937A patent/KR20010075647A/ko not_active Application Discontinuation
- 1999-10-13 WO PCT/EP1999/007682 patent/WO2000023423A1/de active IP Right Grant
- 1999-10-13 DE DE59913608T patent/DE59913608D1/de not_active Expired - Fee Related
- 1999-10-13 AT AT99953799T patent/ATE330942T1/de not_active IP Right Cessation
- 1999-10-13 AU AU10365/00A patent/AU765446B2/en not_active Ceased
- 1999-10-13 US US09/807,218 patent/US6328855B1/en not_active Expired - Fee Related
- 1999-10-13 JP JP2000577151A patent/JP3842044B2/ja not_active Expired - Fee Related
-
2001
- 2001-04-10 NO NO20011822A patent/NO20011822L/no not_active Application Discontinuation
-
2002
- 2002-03-15 HK HK02102013.7A patent/HK1040251A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ATE330942T1 (de) | 2006-07-15 |
AU1036500A (en) | 2000-05-08 |
JP3842044B2 (ja) | 2006-11-08 |
NO20011822D0 (no) | 2001-04-10 |
DE59913608D1 (de) | 2006-08-03 |
EP1123278B1 (de) | 2006-06-21 |
CN1324346A (zh) | 2001-11-28 |
HK1040251A1 (zh) | 2002-05-31 |
IL142585A0 (en) | 2002-03-10 |
CA2347757A1 (en) | 2000-04-27 |
US6328855B1 (en) | 2001-12-11 |
CZ20011422A3 (cs) | 2001-08-15 |
KR20010075647A (ko) | 2001-08-09 |
AU765446B2 (en) | 2003-09-18 |
EP1123278A1 (de) | 2001-08-16 |
HUP0104127A2 (hu) | 2002-03-28 |
JP2002527505A (ja) | 2002-08-27 |
DE19848521A1 (de) | 2000-04-27 |
CA2347757C (en) | 2005-05-17 |
NO20011822L (no) | 2001-04-20 |
WO2000023423A1 (de) | 2000-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A, 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |