BR9909717A - Fatores angiogênicos terapêuticos e métodos para seu uso - Google Patents
Fatores angiogênicos terapêuticos e métodos para seu usoInfo
- Publication number
- BR9909717A BR9909717A BR9909717-6A BR9909717A BR9909717A BR 9909717 A BR9909717 A BR 9909717A BR 9909717 A BR9909717 A BR 9909717A BR 9909717 A BR9909717 A BR 9909717A
- Authority
- BR
- Brazil
- Prior art keywords
- poly
- angiogenic factor
- vehicle
- pleiotropin
- animal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Patente de Invenção: <B>"FATORES ANGIOGêNICOS TERAPêUTICOS E MéTODOS PARA SEU USO"<D>. São proporcionados métodos para estimulação da angiogênese em um ser humano ou animal que precise da mesma. Também são proporcionadas composições compreendendo o fator angiogênico em um veículo farmaceuticamente aceitável. Em uma concretização, o método compreende a administração ao ser humano ou outro animal de uma quantidade terapeuticamente efetiva de um fator angiogênico, tal como uma proteína de pleiotropina ou midkine, em um veículo farmaceuticamente aceitável. O veículo, em uma concretização, compreende uma matriz de liberação controlada, tal como um polímero, que permite a liberação controlada do fator angiogênico. O polímero pode ser biodegradável e/ou biodesgastável e de preferência biocompatível. Polímeros os quais podem ser usados para liberação controlada incluem, por exemplo, poli ( esteres), poli (anidridos) e poli (aminoácidos). Polímeros exemplificativos incluem copolímeros em blocos de poli (aminoácido) de elastina de seda e poli-lactídeo-co-glicolídeo. Em uma outra concretização, o fator angiogênico pode ser proporcionado em um veículo compreendendo um lipossoma, tal como um lipossoma hetero-vesicular. O veículo, tal como lipossoma, pode ser proporcionado com um ligante de objetivação capaz de levar o veículo a um local pré-selecionado no corpo. O fator angiogênico pode ser administrado ao sistema vascular, por exemplo, o sistema cardiovascular ou ao sistema vacular periférico. Em uma concretização preferida, o fator angiogênico é uma proteína de pleiotropina ou uma protéina midkine. Em outra concretização, é proporcionado um método para estimulação da angiogênese em um ser humano ou animal compreendendo a administração de uma quantidade terapeuticamente efetiva de um vetor de transferência de gene que codifica a produção de uma proteína de pleiotropina ou midkine em um veículo farmaceuticamente aceitável. O vetor de transferência de gene pode ser, por exemplo, DNA nu ou um vetor viral, e pode ser administrado, por exemplo, em combinação com lipossomas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8215598P | 1998-04-17 | 1998-04-17 | |
PCT/US1999/008420 WO1999053943A2 (en) | 1998-04-17 | 1999-04-16 | Therapeutic angiogenic factors and methods for their use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909717A true BR9909717A (pt) | 2000-12-26 |
Family
ID=22169397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909717-6A BR9909717A (pt) | 1998-04-17 | 1999-04-16 | Fatores angiogênicos terapêuticos e métodos para seu uso |
Country Status (11)
Country | Link |
---|---|
US (2) | US20030185794A1 (pt) |
EP (1) | EP1071445A2 (pt) |
JP (1) | JP2002512200A (pt) |
CN (1) | CN1379681A (pt) |
AU (1) | AU760664B2 (pt) |
BR (1) | BR9909717A (pt) |
CA (1) | CA2329010A1 (pt) |
IL (1) | IL139030A0 (pt) |
MX (1) | MXPA00010110A (pt) |
NO (1) | NO20005190L (pt) |
WO (1) | WO1999053943A2 (pt) |
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US6903244B1 (en) | 1999-02-26 | 2005-06-07 | University Of Utah Research Foundation | Mice which are +/− or −/− for the elastin gene as models for vascular disease |
MXPA02000128A (es) * | 1999-06-22 | 2002-06-21 | Res Dev Foundation | Material mejorado de heridas para mejorar curacion de heridas. |
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US6364912B1 (en) * | 1999-09-17 | 2002-04-02 | Depuy Orthopeaedics, Inc. | Pleiotrophin-based compositions for enhancing connective tissue repair |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
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CN100506293C (zh) | 2000-03-15 | 2009-07-01 | 祥丰医疗有限公司 | 促进内皮细胞粘附的涂层 |
US20030229393A1 (en) * | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
US20070055367A1 (en) * | 2000-03-15 | 2007-03-08 | Orbus Medical Technologies, Inc. | Medical device with coating that promotes endothelial cell adherence and differentiation |
US8460367B2 (en) * | 2000-03-15 | 2013-06-11 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US20040023863A1 (en) * | 2000-04-06 | 2004-02-05 | Franco Wayne P. | Methods of use growth factors for treating heart disease |
CA2412650C (en) * | 2000-06-14 | 2011-08-02 | Georgetown University | Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders |
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US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
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US7888485B2 (en) * | 2003-03-26 | 2011-02-15 | Georgetown University | Anti-pleiotrophin antibodies and methods of use thereof |
US8383158B2 (en) * | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
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US20080039382A1 (en) * | 2003-05-29 | 2008-02-14 | Lee Randall J | Compositions related to pleiotrophin methods and uses thereof |
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NZ545086A (en) * | 2003-08-07 | 2011-06-30 | Healor Ltd | Pharmaceutical compositions and methods for accelerating wound healing |
AU2004289287A1 (en) * | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
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WO2005107817A2 (en) * | 2004-04-30 | 2005-11-17 | Orbus Medical Technologies, Inc. | Medical device with coating for capturing genetically-altered cells and methods of using same |
WO2006042197A2 (en) * | 2004-10-11 | 2006-04-20 | The Board Of Trustees Of The Leland Standford Junior University | Use of del-1 in hair, bone and cartilage regeneration |
JP4791770B2 (ja) * | 2004-12-06 | 2011-10-12 | 株式会社セルシグナルズ | 心筋障害又は心不全の治療もしくは予防組成物 |
US7595295B2 (en) * | 2005-02-25 | 2009-09-29 | Rush University Medical Center | Use of pleiotrophin to promote neurogeneration |
US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
CA2663547C (en) | 2006-09-22 | 2020-08-25 | Orthologic Corp. | Method of treating endothelial dysfunction |
WO2008047904A1 (fr) * | 2006-10-20 | 2008-04-24 | National University Corporation Nagoya University | Agent thérapeutique pour vasculopathie périphérique oblitérante et utilisation |
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-
1999
- 1999-04-16 BR BR9909717-6A patent/BR9909717A/pt not_active IP Right Cessation
- 1999-04-16 MX MXPA00010110A patent/MXPA00010110A/es unknown
- 1999-04-16 IL IL13903099A patent/IL139030A0/xx unknown
- 1999-04-16 CA CA002329010A patent/CA2329010A1/en not_active Abandoned
- 1999-04-16 WO PCT/US1999/008420 patent/WO1999053943A2/en not_active Application Discontinuation
- 1999-04-16 JP JP2000544346A patent/JP2002512200A/ja not_active Withdrawn
- 1999-04-16 AU AU34955/99A patent/AU760664B2/en not_active Ceased
- 1999-04-16 EP EP99916697A patent/EP1071445A2/en not_active Withdrawn
- 1999-04-16 CN CN99806834A patent/CN1379681A/zh active Pending
-
2000
- 2000-10-16 NO NO20005190A patent/NO20005190L/no not_active Application Discontinuation
-
2002
- 2002-12-18 US US10/323,533 patent/US20030185794A1/en not_active Abandoned
-
2003
- 2003-06-09 US US10/457,915 patent/US20030202960A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3495599A (en) | 1999-11-08 |
EP1071445A2 (en) | 2001-01-31 |
NO20005190D0 (no) | 2000-10-16 |
WO1999053943A3 (en) | 2000-01-20 |
US20030185794A1 (en) | 2003-10-02 |
AU760664B2 (en) | 2003-05-22 |
IL139030A0 (en) | 2001-11-25 |
US20030202960A1 (en) | 2003-10-30 |
NO20005190L (no) | 2000-11-30 |
CN1379681A (zh) | 2002-11-13 |
CA2329010A1 (en) | 1999-10-28 |
WO1999053943A2 (en) | 1999-10-28 |
MXPA00010110A (es) | 2002-08-06 |
JP2002512200A (ja) | 2002-04-23 |
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