BR9908096A - Proteìna 3 da zona pelúcida humana (hzp3), ativa, recombinante - Google Patents

Proteìna 3 da zona pelúcida humana (hzp3), ativa, recombinante

Info

Publication number
BR9908096A
BR9908096A BR9908096-6A BR9908096A BR9908096A BR 9908096 A BR9908096 A BR 9908096A BR 9908096 A BR9908096 A BR 9908096A BR 9908096 A BR9908096 A BR 9908096A
Authority
BR
Brazil
Prior art keywords
recombinant
hzp3
active
human
protein
Prior art date
Application number
BR9908096-6A
Other languages
English (en)
Inventor
Ke-Wen Dong
Sergio Oehninger
William E Gibbons
Original Assignee
Eastern Virginia Med School
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastern Virginia Med School filed Critical Eastern Virginia Med School
Publication of BR9908096A publication Critical patent/BR9908096A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Patente de Invenção: <B>"PROTEìNA 3 DA ZONA PELúCIDA HUMANA (hZP3), ATIVA, RECOMBINANTE"<D>. A invenção refere-se a métodos para produzir proteína de zona pelúcida recombinante ("rhZP3") e peptídio glicosilado tendo atividade biológica de ligação a espermatozóides humanos. Uma linhagem de célula ovariana humana é usada para produzir rhZP3 tendo um padrão de glicosilação necessário para atividade biológica total. São discutidos métodos para determinar peptídios úteis com atividade de ligação a espermatozóides humanos e sínteses dos mesmos, bem como o uso desses peptídios e proteínas em terapêuticos e diagnósticos.
BR9908096-6A 1998-02-19 1999-02-19 Proteìna 3 da zona pelúcida humana (hzp3), ativa, recombinante BR9908096A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7507998P 1998-02-19 1998-02-19
PCT/US1999/003273 WO1999042581A1 (en) 1998-02-19 1999-02-19 RECOMBINANT ACTIVE HUMAN ZONA PELLUCIDA PROTEIN 3 (hZP3)

Publications (1)

Publication Number Publication Date
BR9908096A true BR9908096A (pt) 2000-10-31

Family

ID=22123416

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9908096-6A BR9908096A (pt) 1998-02-19 1999-02-19 Proteìna 3 da zona pelúcida humana (hzp3), ativa, recombinante

Country Status (13)

Country Link
US (1) US7019114B2 (pt)
EP (1) EP1056858B1 (pt)
JP (1) JP2002504330A (pt)
CN (1) CN1291229A (pt)
AT (1) ATE284443T1 (pt)
AU (1) AU763247C (pt)
BR (1) BR9908096A (pt)
CA (1) CA2321196A1 (pt)
DE (1) DE69922489T2 (pt)
ES (1) ES2234274T3 (pt)
HK (1) HK1032608A1 (pt)
TW (1) TWI229085B (pt)
WO (1) WO1999042581A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7019114B2 (en) 1998-02-19 2006-03-28 Eastern Virginia Medical School Recombinant, biologically active human zona pellucida protein 3 (HZP3) to test male fertility
US7037663B2 (en) 1998-02-19 2006-05-02 Eastern Virginia Medical School Human zona pellucida protein 3 and uses thereof
CA2456821A1 (en) * 2001-08-02 2003-02-13 Trinity Biomedical Technology Corporation Human zona pellucida proteins and methods of their use in diagnosing male infertility
ES2348524T3 (es) * 2005-11-16 2010-12-07 Pantarhei Bioscience B.V. Composición farmacéutica para tratar o prevenir el cáncer de ovarios.
CN101365473B (zh) 2005-11-16 2013-04-03 潘塔希生物科学股份有限公司 用于治疗或预防卵巢癌的药物组合物
US20080187549A1 (en) * 2007-02-07 2008-08-07 Morey William A Polyantigenic-based (multiple antigens) modi or set of methods for developing infertility vaccines
CN103179977B (zh) 2010-08-27 2016-10-26 潘塔希生物科学股份有限公司 治疗前列腺癌的免疫治疗方法
WO2016080830A2 (en) 2014-11-18 2016-05-26 Pantarhei Bioscience B.V. Immunotherapeutic method for treating pancreatic cancer
MX2021002145A (es) 2018-08-24 2021-04-28 Spermosens Ab Biosensor para esterilidad masculina.
CN110170044A (zh) * 2019-06-22 2019-08-27 江西省妇幼保健院 Tat-tdrg1在制备治疗弱精子症药物中的应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) * 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) * 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4444879A (en) 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5352605A (en) * 1983-01-17 1994-10-04 Monsanto Company Chimeric genes for transforming plant cells using viral promoters
US5034322A (en) * 1983-01-17 1991-07-23 Monsanto Company Chimeric genes suitable for expression in plant cells
US4960704A (en) * 1983-07-22 1990-10-02 Eli Lilly And Company Modified antibiotic resistance gene
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL71691A (en) * 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
DE176971T1 (de) * 1984-09-29 1986-11-27 Wakamoto Pharmaceutical Co., Ltd., Tokio/Tokyo Fuer ein thermostabiles beta-galaktosidase, kodierendes gen, dieses gen enthaltender bacillus-subtilis, das durch dieses gen kodiertes enzym und verfahren zu dessen herstellung.
US4996297A (en) 1987-10-07 1991-02-26 Zonagen, Inc. Recombinantly expressed rabbit zona pellucida polypeptides
US5869053A (en) * 1988-03-04 1999-02-09 Cancer Research Campaign Technology, Ltd. 5T4 antigen from human trophoblasts
JPH05500654A (ja) 1989-06-12 1993-02-12 アメリカ合衆国 クローン化透明帯遺伝子を基本とする避妊ワクチン
US5641487A (en) * 1989-06-12 1997-06-24 The Government Of The United States Of America As Represented By The Secretary Department Of Health And Human Services Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
JPH06500690A (ja) * 1990-08-27 1994-01-27 アクゾ・エヌ・ヴエー ヒト卵透明帯タンパク質ｚｐ３
ZA919299B (en) 1990-11-26 1992-08-26 Akzo Nv Method for the production of antibodies
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
AU3611793A (en) 1992-02-04 1993-09-01 Colorado State University Research Foundation Composition and method to prevent conception or to cause sterility in animals
US5851763A (en) * 1992-09-17 1998-12-22 Institut Pasteur Rapid detection of antibiotic resistance in mycobacterium tuberculosis
EP0658213B1 (en) * 1992-08-28 1998-11-18 Trustees Of Tufts College Multiple antibiotic resistance operon assays
US5744345A (en) * 1992-10-05 1998-04-28 Takara Shuzo Co., Ltd. Hyperthermostable β-galactosidase gene, enzyme encoded thereby, and process for production
WO1994010304A1 (en) 1992-11-02 1994-05-11 Akzo Nobel N.V. Marmoset zona pellucida protein zp3
WO1994011019A1 (en) * 1992-11-09 1994-05-26 Zonagen, Inc. Materials and methods for immunocontraception
US6001599A (en) 1992-11-09 1999-12-14 Zonagen, Inc. DNAs encoding mammalian ZPBs
US5888981A (en) * 1993-06-14 1999-03-30 Basf Aktiengesellschaft Methods for regulating gene expression
ES2140359T1 (es) * 1993-06-14 2000-03-01 Basf Ag Control preciso de expresion genetica en celulas eucarioticas mediante promotores que responden a la tetaciclina.
WO1995027206A1 (en) 1994-03-31 1995-10-12 Board Of Regents, The University Of Texas System Mannose in vitro binding assay and uses thereof in sperm evaluation
US5851817A (en) * 1994-07-19 1998-12-22 Board Of Regents, The University Of Texas System Species specific egg-binding proteins of sperm
AU3362895A (en) 1994-08-11 1996-03-07 Duke University Use of zrk peptide sequences in contraception
CN1158623A (zh) 1994-08-22 1997-09-03 阿克佐诺贝尔公司 新的免疫避孕肽
US5710038A (en) * 1994-11-25 1998-01-20 Universite De Montreal Primary cultures of normal and tumoral human ovarian epithelium
US5650321A (en) * 1995-01-27 1997-07-22 Trustees Of Tufts College Identification and isolation of new genes of a bacterial multiple antibiotic resistance regulon
US5703057A (en) * 1995-04-07 1997-12-30 Board Of Regents The University Of Texas System Expression library immunization
US5851796A (en) * 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
US5821350A (en) * 1995-11-01 1998-10-13 Nexia Biotechnologies, Inc. Aspergillus niger beta-galactosidase gene
US5891718A (en) * 1996-03-27 1999-04-06 Vical Incorporated Tetracycline inducible/repressible systems
US5925541A (en) * 1996-09-11 1999-07-20 New York Blood Center, Inc. Endo-β-galactosidase
WO1998037185A2 (en) 1997-02-20 1998-08-27 The Board Of Regents Of The University Of Texas System Vectors for controlled gene expression
US6132952A (en) 1997-05-30 2000-10-17 Saint Barnabas Medical Center Storage system comprising an emptied zona pellucida and spermatozoa placed therein and a method of cryopreservation
US5968773A (en) * 1997-11-14 1999-10-19 Heddle; John A. System and method for regulation of gene expression
AU2096199A (en) 1998-01-02 1999-07-26 University Of Georgia Research Foundation, Inc., The Fertility impairing vaccine and method of use
US7037663B2 (en) * 1998-02-19 2006-05-02 Eastern Virginia Medical School Human zona pellucida protein 3 and uses thereof
US7019114B2 (en) 1998-02-19 2006-03-28 Eastern Virginia Medical School Recombinant, biologically active human zona pellucida protein 3 (HZP3) to test male fertility
US6300311B1 (en) 1998-04-14 2001-10-09 Texas Tech University Regulation of vertebrate ovarian maturation and function using growth factors
JP2003528564A (ja) 1998-06-06 2003-09-30 ジェノスティック ファーマ リミテッド 遺伝的プロファイリングに使用するプローブ
AU4158799A (en) 1998-06-06 1999-12-30 Genostic Pharma Limited Probes used for genetic filing
WO1999065520A1 (en) 1998-06-19 1999-12-23 University Of Virginia Patent Foundation Egg surface proteins and methods for use for modulating fertility
WO1999065928A2 (en) 1998-06-19 1999-12-23 Genzyme Corporation Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues
CA2456821A1 (en) * 2001-08-02 2003-02-13 Trinity Biomedical Technology Corporation Human zona pellucida proteins and methods of their use in diagnosing male infertility

Also Published As

Publication number Publication date
ATE284443T1 (de) 2004-12-15
AU763247B2 (en) 2003-07-17
US7019114B2 (en) 2006-03-28
HK1032608A1 (en) 2001-07-27
TWI229085B (en) 2005-03-11
DE69922489D1 (de) 2005-01-13
DE69922489T2 (de) 2005-12-15
JP2002504330A (ja) 2002-02-12
EP1056858B1 (en) 2004-12-08
EP1056858A1 (en) 2000-12-06
AU3294699A (en) 1999-09-06
ES2234274T3 (es) 2005-06-16
AU763247C (en) 2005-05-19
US20020172982A1 (en) 2002-11-21
CN1291229A (zh) 2001-04-11
CA2321196A1 (en) 1999-08-26
WO1999042581A1 (en) 1999-08-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1994 DE 24/03/2009