BR9905319A - Processo para fabricação de d,l-alfa tocoferol - Google Patents

Processo para fabricação de d,l-alfa tocoferol

Info

Publication number
BR9905319A
BR9905319A BR9905319-5A BR9905319A BR9905319A BR 9905319 A BR9905319 A BR 9905319A BR 9905319 A BR9905319 A BR 9905319A BR 9905319 A BR9905319 A BR 9905319A
Authority
BR
Brazil
Prior art keywords
met
solvent
manufacturing
group
metal atom
Prior art date
Application number
BR9905319-5A
Other languages
English (en)
Inventor
Werner Bonrarth
Shaoning Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9905319A publication Critical patent/BR9905319A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA FABRICAçãO DE D,L-ALFA TOCOFEROL"<D>. Um processo para fabricação de d,l-<244>-tocoferol pela condensação catalisada de trimetilhidroquinona com isofitol compreende a execução da condensação na presença de bis(trifluorometilsulfonil)amina [HN(SO~ 2~CF~ 3~)~ 2~] ou um sal de metal da fómula Met[N(SO~ 2~CF~ 3~)~ 2~]~ n~ (I), onde Met significa um átomo de metal selecionado do grupo de boro, magnésio, alumínio, silício, escândio, titânio, vanádio, manganês, ferro, cobalto, níquel, cobre, zinco, ítrio, zicrónio, ródio, paládio, prata, estanho, lantânio, cério, neodímio, prasiodímio, európio, disprósio, itérbio, platino e ouro n significa a valência correspondente (1, 2, 3 ou 4) do átomo de metal Met, como catalisador e do dióxido de carbono supercrítico ou óxido nitroso como solvente. Um outro solvente (cossolvente) pode ser utilizado, o qual é um alcanol alifático mais baixo, uma cetona ou um hidrocarboneto. O produto do processo é o membro mais ativo do grupo vitamina E.
BR9905319-5A 1998-11-11 1999-11-10 Processo para fabricação de d,l-alfa tocoferol BR9905319A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98121457 1998-11-11

Publications (1)

Publication Number Publication Date
BR9905319A true BR9905319A (pt) 2001-04-17

Family

ID=8232963

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9905319-5A BR9905319A (pt) 1998-11-11 1999-11-10 Processo para fabricação de d,l-alfa tocoferol

Country Status (6)

Country Link
US (1) US6423851B2 (pt)
JP (1) JP2000143656A (pt)
KR (1) KR20000035335A (pt)
CN (1) CN1253950A (pt)
BR (1) BR9905319A (pt)
CA (1) CA2288851A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020042176A (ko) * 2000-11-30 2002-06-05 유승렬 고순도의 ＤＬ-α-토코페롤을 고수율로 제조하는 방법
WO2002085838A1 (en) 2001-04-24 2002-10-31 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
CA2494404A1 (en) 2002-08-02 2004-02-12 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
DE112004001149B4 (de) * 2003-07-08 2020-08-20 Dsm Ip Assets B.V. Herstellung von Tocopherolen unter Verwendung eines Wismutkatalysators
JP4917435B2 (ja) * 2003-12-05 2012-04-18 ディーエスエム アイピー アセッツ ビー．ブイ． アルケニル化ヒドロキシル化芳香族化合物、クロマン化合物、およびそれらのアシル化誘導体の製造方法
JP4999690B2 (ja) * 2004-06-11 2012-08-15 ディーエスエム アイピー アセッツ ビー．ブイ． クロマン誘導体、特にα−トコフェロールおよびそのアルカノエートの製造方法
US8226850B1 (en) * 2009-09-22 2012-07-24 Clemson University Research Foundation Thermally enhanced oxygen scavengers including a transition metal and a free radical scavenger
CN105820149A (zh) * 2016-04-28 2016-08-03 能特科技有限公司 一种金属催化剂制备α-生育酚的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2411969A (en) 1938-03-31 1946-12-03 Hoffmann La Roche Process for the preparation of synthetic dl-tocopherols
US3459773A (en) 1966-12-27 1969-08-05 Takasago Perfumery Co Ltd Process for producing alpha-tocopherol and its esters
US3444213A (en) 1967-07-12 1969-05-13 Eastman Kodak Co Continuous process for producing dl alpha tocopherol
CH547278A (de) 1971-01-11 1974-03-29 Hoffmann La Roche Verfahren zur herstellung von chromanderivaten.
DE4243464A1 (de) 1992-12-22 1994-06-23 Basf Ag Verfahren zur Herstellung von alpha-Tocopherol und alpha-Tocopherylacetat in flüssigem oder überkritischem Kohlendioxid
JP3848380B2 (ja) 1993-12-14 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 α−トコフェロール誘導体の製造法
US5908939A (en) 1996-11-11 1999-06-01 Roche Vitamins Inc. Method of making D,L-A-tocopherol

Also Published As

Publication number Publication date
US20020010347A1 (en) 2002-01-24
US6423851B2 (en) 2002-07-23
CN1253950A (zh) 2000-05-24
KR20000035335A (ko) 2000-06-26
JP2000143656A (ja) 2000-05-26
CA2288851A1 (en) 2000-05-11

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]