BR9815912A - Cepa viral de hepatite b induzida por vacina e seus usos - Google Patents
Cepa viral de hepatite b induzida por vacina e seus usosInfo
- Publication number
- BR9815912A BR9815912A BR9815912A BR9815912A BR9815912A BR 9815912 A BR9815912 A BR 9815912A BR 9815912 A BR9815912 A BR 9815912A BR 9815912 A BR9815912 A BR 9815912A BR 9815912 A BR9815912 A BR 9815912A
- Authority
- BR
- Brazil
- Prior art keywords
- hepatitis
- present
- provides
- strain
- peptide
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
- G01N33/5764—Hepatitis B surface antigen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
Abstract
"CEPA VIRAL DE HEPATITE B INDUZIDA POR VACINAS E SEUS USOS". A presente invenção fornece uma cepa isolada de vírus da Hepatite B designada Cepa Singapore S-145-Antigeno Superficial de Vírus da Hepatite B Humana (Glicina para Arginina) cujo genona viral constituinte é depositado sob os Nos. de Acessão P97121504, P97121505 e P97121506 na European Collection of Cell Culture em 15 de dezembro de 1997. A presente invenção também provê um ácido nucléico isolado codificando um polipeptídeo que é um antígeno superficial principal, mutante, de uma cepa do vírus de hepatite B, tal polipeptídeo tendo uma seq³ência de aminoácidos que difere da seq³ência de aminoácidos de um antígeno superficial principal de um vírus de hepatite B do tipo selvagem em que o aminoácido na posiçao número 145 do referido polipeptídeo é uma arginina em vez de uma glicina, e o peptídeo purificado. A presente invenção provê ainda um ácido nucléico isolado que codifica um peptídeo, onde o peptídeo é codificado por uma molécula de ácido nucléico compreendendo nucleotídeos 527 até 595 da SEQ. ID. NO. 1, e o peptídeo purificado. A presente invenção também provê vários métodos utilizando os polipeptídeos e ácidos nucléicos isolados, revelados. A presente invenção também provê vários usos da cepa viral e suas proteínas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SG1998/000045 WO1999066047A1 (en) | 1998-06-19 | 1998-06-19 | A vaccine-induced hepatitis b viral strain and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9815912A true BR9815912A (pt) | 2002-02-05 |
Family
ID=20429861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9815912A BR9815912A (pt) | 1998-06-19 | 1998-06-19 | Cepa viral de hepatite b induzida por vacina e seus usos |
Country Status (22)
Country | Link |
---|---|
US (2) | US7038035B1 (pt) |
EP (1) | EP1086232A1 (pt) |
JP (1) | JP2002518013A (pt) |
KR (1) | KR100498117B1 (pt) |
CN (1) | CN1255540C (pt) |
AR (1) | AR020092A1 (pt) |
AU (1) | AU756858B2 (pt) |
BG (1) | BG105065A (pt) |
BR (1) | BR9815912A (pt) |
CA (1) | CA2332173A1 (pt) |
HU (1) | HUP0103258A3 (pt) |
IL (1) | IL140363A0 (pt) |
IS (1) | IS5777A (pt) |
MX (1) | MXPA00012724A (pt) |
MY (1) | MY135991A (pt) |
NO (1) | NO20006457L (pt) |
NZ (1) | NZ508892A (pt) |
PL (1) | PL191312B1 (pt) |
TR (1) | TR200003778T2 (pt) |
UA (1) | UA73475C2 (pt) |
WO (1) | WO1999066047A1 (pt) |
YU (1) | YU80500A (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPP967999A0 (en) * | 1999-04-09 | 1999-05-06 | North Western Health Care Network | Viral variants |
AUPQ810900A0 (en) * | 2000-06-09 | 2000-07-06 | Austin and Repatriation Medical Centre, The | Viral variants and methods of using same |
CN100355777C (zh) * | 2003-02-10 | 2007-12-19 | 文洪模 | 乙型肝炎病毒pre-S突变蛋白及其制备方法与应用 |
US20060057670A1 (en) * | 2004-09-10 | 2006-03-16 | The Chinese University Of Hong Kong | Genomic markers of hepatitis B virus associated with hepatocellular carcinomas |
EP1806363B1 (en) * | 2004-09-22 | 2013-09-04 | Advanced Life Science Institute, Inc. | METHOD OF DETECTING HEPATITIS B VIRUS s ANTIGEN |
TW200643171A (en) * | 2005-06-07 | 2006-12-16 | Temasek Life Sciences Lab Ltd | Porcine circovirus type 2 vaccines |
CN101948932B (zh) * | 2010-07-22 | 2013-04-03 | 中国人民解放军第三〇二医院 | 滚环扩增加跨缺口荧光定量PCR检测乙型肝炎病毒cccDNA试剂盒 |
CN101948933B (zh) * | 2010-07-22 | 2013-04-03 | 中国人民解放军第三〇二医院 | 检测石蜡包埋肝组织乙型肝炎病毒cccDNA的试剂盒 |
RU2586513C1 (ru) * | 2015-04-24 | 2016-06-10 | Закрытое акционерное общество научно-производственная компания "Комбиотех" | РЕКОМБИНАНТНЫЙ ШТАММ ДРОЖЖЕЙ Hansenula polymorpha - ПРОДУЦЕНТ МУТАНТНОГО ПОВЕРХНОСТНОГО АНТИГЕНА ВИРУСА ГЕПАТИТА В (ВАРИАНТЫ) |
RU2603729C2 (ru) * | 2015-04-24 | 2016-11-27 | Закрытое акционерное общество научно-производственная компания "Комбиотех" | Рекомбинантная вакцина для профилактики вирусного гепатита в (варианты) |
US11497808B2 (en) | 2019-09-30 | 2022-11-15 | Gilead Sciences, Inc. | HBV vaccines and methods treating HBV |
CN113201051B (zh) * | 2021-04-27 | 2022-08-02 | 复旦大学 | 一种乙肝病毒表面蛋白突变体及其在抗乙肝病毒中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9007024D0 (en) * | 1990-03-29 | 1990-05-30 | Imperial College | Novel vaccine |
US5955089A (en) * | 1993-04-20 | 1999-09-21 | Uab Research Foundation | Strain selection of pneumococcal surface proteins |
GB9401987D0 (en) * | 1994-02-02 | 1994-03-30 | Imperial College | Modified nucleic acid |
US5830759A (en) * | 1994-08-18 | 1998-11-03 | The Trustees Of Columbia University In The City Of New York | Unique associated Kaposi's sarcoma virus sequences and uses thereof |
EP0969863A4 (en) | 1996-09-18 | 2001-11-07 | Univ Texas | DEFECTIVE VIRAL INTERFERENCE PARTICLES AND THEIR USE. |
-
1998
- 1998-06-19 KR KR10-2000-7014443A patent/KR100498117B1/ko not_active IP Right Cessation
- 1998-06-19 UA UA2000127296A patent/UA73475C2/uk unknown
- 1998-06-19 YU YU80500A patent/YU80500A/sh unknown
- 1998-06-19 CN CNB988142007A patent/CN1255540C/zh not_active Expired - Fee Related
- 1998-06-19 AU AU77950/98A patent/AU756858B2/en not_active Ceased
- 1998-06-19 CA CA 2332173 patent/CA2332173A1/en not_active Abandoned
- 1998-06-19 US US09/719,533 patent/US7038035B1/en not_active Expired - Fee Related
- 1998-06-19 NZ NZ50889298A patent/NZ508892A/xx unknown
- 1998-06-19 MX MXPA00012724A patent/MXPA00012724A/es unknown
- 1998-06-19 HU HU0103258A patent/HUP0103258A3/hu not_active Application Discontinuation
- 1998-06-19 EP EP19980926022 patent/EP1086232A1/en not_active Withdrawn
- 1998-06-19 BR BR9815912A patent/BR9815912A/pt not_active Application Discontinuation
- 1998-06-19 PL PL345203A patent/PL191312B1/pl not_active IP Right Cessation
- 1998-06-19 JP JP2000554856A patent/JP2002518013A/ja active Pending
- 1998-06-19 IL IL14036398A patent/IL140363A0/xx unknown
- 1998-06-19 WO PCT/SG1998/000045 patent/WO1999066047A1/en not_active Application Discontinuation
- 1998-06-19 TR TR200003778T patent/TR200003778T2/xx unknown
-
1999
- 1999-06-17 MY MYPI99002505A patent/MY135991A/en unknown
- 1999-06-18 AR ARP990102961 patent/AR020092A1/es unknown
-
2000
- 2000-12-18 BG BG105065A patent/BG105065A/xx unknown
- 2000-12-18 NO NO20006457A patent/NO20006457L/no not_active Application Discontinuation
- 2000-12-19 IS IS5777A patent/IS5777A/is unknown
-
2006
- 2006-03-20 US US11/385,013 patent/US20070026422A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA00012724A (es) | 2003-02-10 |
PL191312B1 (pl) | 2006-04-28 |
AR020092A1 (es) | 2002-04-10 |
IS5777A (is) | 2000-12-19 |
PL345203A1 (en) | 2001-12-03 |
JP2002518013A (ja) | 2002-06-25 |
BG105065A (en) | 2001-09-28 |
KR100498117B1 (ko) | 2005-07-01 |
EP1086232A1 (en) | 2001-03-28 |
IL140363A0 (en) | 2002-02-10 |
NO20006457L (no) | 2001-02-16 |
HUP0103258A3 (en) | 2003-10-28 |
CN1255540C (zh) | 2006-05-10 |
KR20010106128A (ko) | 2001-11-29 |
MY135991A (en) | 2008-07-31 |
HUP0103258A2 (hu) | 2001-12-28 |
TR200003778T2 (tr) | 2001-06-21 |
WO1999066047A1 (en) | 1999-12-23 |
US7038035B1 (en) | 2006-05-02 |
NZ508892A (en) | 2004-02-27 |
NO20006457D0 (no) | 2000-12-18 |
AU7795098A (en) | 2000-01-05 |
AU756858B2 (en) | 2003-01-23 |
CN1304453A (zh) | 2001-07-18 |
US20070026422A1 (en) | 2007-02-01 |
YU80500A (sh) | 2004-05-12 |
UA73475C2 (en) | 2005-08-15 |
CA2332173A1 (en) | 1999-12-23 |
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Legal Events
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B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART 36 DA LPI (LEI 9.279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. |