BR9814699A - Derivados alfa-hidróxi, amino e halo de ácidos beta-sulfonil hidroxâmico como inibidores de metaloproteinases matrizes - Google Patents

Derivados alfa-hidróxi, amino e halo de ácidos beta-sulfonil hidroxâmico como inibidores de metaloproteinases matrizes

Info

Publication number
BR9814699A
BR9814699A BR9814699-8A BR9814699A BR9814699A BR 9814699 A BR9814699 A BR 9814699A BR 9814699 A BR9814699 A BR 9814699A BR 9814699 A BR9814699 A BR 9814699A
Authority
BR
Brazil
Prior art keywords
substituted
unsubstituted
beta
alpha
amino
Prior art date
Application number
BR9814699-8A
Other languages
English (en)
Inventor
Martha A Warpehoski
Mark Allen Mitchell
Donald E Harper
Linda Louise Maggiora
Original Assignee
Pharmacia & Up John Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Up John Company filed Critical Pharmacia & Up John Company
Publication of BR9814699A publication Critical patent/BR9814699A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

Patente de Invenção: <B>"DERIVADOS ALFA-HIDRóXI, AMINO E HALO DE áCIDOS BETA-SULFONIL HIDROXâMICO COMO INIBIDORES DE METALOPROTEINASES MATRIZES"<D>. A presente invenção propicia um composto de fórmula I ou sais farmaceuticamente aceitáveis deste, onde R~ 1~ é C~ 4-12~ alquila, C~ 4-12~alquenila, C~ 4-12~ alquinila, (CH~ 2~)~ h~-C~ 3-8~ cicloalquila, -(CH~ 2~)~ h~arila substituído e não-substituído, -(CH~ 2~)~ h~het substituído e não-substituído, R~ 2~ é C~ 1-12~ alquila substituído e não-substituído, C~ 2-12~alquenila substituído e não-substituído, C~ 2-12~ alquinila substituído e não-substituído -(CH~ 2~)~ h~-C~ 3-8~ cicloalquila substituído e não-substituído, -CH~ 2~)~ h~-C~ 3-8~ cicloalquenila substituído e não-substituído, -CH~ 2~)~ h~-arila substituído e não-substituído, anel heterocíclico -(CH~ 2~)~ h~ substituído e não-substituído, -(CH~ 2~)~ i~-X-R~ 4~ substituído e não-substituído (X é -O-, -S(=O)~ j~-, NR~ 7~-, -S(=O)~ 2~NR~ 8~-, ou -C(=O)-) e -(CH~ 2~)~ i~-CHR~ 5~R~ 6~. Os compostos são inibidores de metaloproteinases matrizes envolvidas na degradação tissular.
BR9814699-8A 1997-11-21 1998-11-18 Derivados alfa-hidróxi, amino e halo de ácidos beta-sulfonil hidroxâmico como inibidores de metaloproteinases matrizes BR9814699A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7265597P 1997-11-21 1997-11-21
PCT/IB1998/002154 WO1999026909A2 (en) 1997-11-21 1998-11-18 Alpha-hydroxy, -amino and -fluoro derivatives of beta-sulphonyl hydroxamic acids as matrix metalloproteinases inhibitors

Publications (1)

Publication Number Publication Date
BR9814699A true BR9814699A (pt) 2000-10-03

Family

ID=22108985

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814699-8A BR9814699A (pt) 1997-11-21 1998-11-18 Derivados alfa-hidróxi, amino e halo de ácidos beta-sulfonil hidroxâmico como inibidores de metaloproteinases matrizes

Country Status (24)

Country Link
US (2) US20030166687A1 (pt)
EP (1) EP1037868B1 (pt)
JP (1) JP2001524462A (pt)
KR (1) KR20010032319A (pt)
CN (1) CN1168709C (pt)
AT (1) ATE232192T1 (pt)
AU (1) AU763113B2 (pt)
BG (1) BG104346A (pt)
BR (1) BR9814699A (pt)
CA (1) CA2310401A1 (pt)
DE (1) DE69811273T2 (pt)
DK (1) DK1037868T3 (pt)
EA (1) EA003585B1 (pt)
ES (1) ES2192349T3 (pt)
HU (1) HUP0100812A3 (pt)
IL (1) IL135586A0 (pt)
IS (1) IS1954B (pt)
NO (1) NO20002505L (pt)
NZ (1) NZ503997A (pt)
PL (1) PL341153A1 (pt)
PT (1) PT1037868E (pt)
TR (1) TR200001391T2 (pt)
UA (1) UA66818C2 (pt)
WO (1) WO1999026909A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001524462A (ja) * 1997-11-21 2001-12-04 ファーマシア・アンド・アップジョン・カンパニー マトリックスメタロプロテイナーゼインヒビターとしてのβ−スルホニルヒドロキサム酸のα−ヒドロキシ、−アミノ及びハロ誘導体
GB9927453D0 (en) * 1999-11-19 2000-01-19 Pharmacia & Upjohn Spa Crystalline and optically active form of a-hydroxy derivatives of ›-sulfonyl acid
WO2002030879A2 (en) 2000-09-29 2002-04-18 Prolifix Limited Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors
DE60138658D1 (de) * 2000-09-29 2009-06-18 Topotarget Uk Ltd Carbaminsäurederivate enthaltend eine Amidgruppe zur Behandlung von Malaria
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
WO2007070760A2 (en) * 2005-12-15 2007-06-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2081905B1 (en) * 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
JP5030114B2 (ja) * 2006-09-25 2012-09-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体をモジュレートする化合物
US7539361B2 (en) * 2006-10-05 2009-05-26 Harris Corporation Fiber optic device for measuring a parameter of interest
DE102006049618A1 (de) * 2006-10-20 2008-05-08 Tschesche, Harald, Prof. Dr. Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren
EP2217565B1 (en) * 2007-11-07 2013-05-22 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
US8178568B2 (en) * 2008-07-10 2012-05-15 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the CB2 receptor
KR20110063438A (ko) * 2008-09-25 2011-06-10 베링거 인겔하임 인터내셔날 게엠베하 Ｃｂ2 수용체를 선택적으로 조절하는 설포닐 화합물
US8299103B2 (en) * 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
JP2013505295A (ja) * 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
JP2013517271A (ja) 2010-01-15 2013-05-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
JP5746228B2 (ja) 2010-03-05 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節するテトラゾール化合物
US8846936B2 (en) 2010-07-22 2014-09-30 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the CB2 receptor
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
DK3013796T3 (da) * 2013-06-27 2020-03-16 Lg Chemical Ltd Biarylderivater som gpr120-agonister
RU2748835C1 (ru) 2017-11-27 2021-05-31 Совет Научных И Прикладных Исследований Индол(сульфонил)-n-гидроксибензамидные производные в качестве селективных ингибиторов hdac

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE225343T1 (de) * 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
DK0871439T3 (da) 1996-01-02 2004-08-02 Aventis Pharma Inc Substituerede (aryl, heteroaryl, arylmethyl eller heteroarylmethyl) hydroxamsyreforbindelser
KR20000022532A (ko) 1996-06-27 2000-04-25 오노 야꾸힝 고교 가부시키가이샤 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물
DE69729007T2 (de) 1996-08-07 2005-04-07 Darwin Discovery Ltd., Slough Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
CZ92399A3 (cs) * 1996-09-27 1999-07-14 Pharmacia & Upjohn Company ß-sulfonylhydroxamové kyseliny jako inhibitory matriční metaloproteinázy
AU5337498A (en) * 1997-01-22 1998-08-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted beta-thiocarboxylic acids
AU5493598A (en) 1997-02-07 1998-08-26 Pfizer Inc. N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
US6362183B1 (en) * 1997-03-04 2002-03-26 G. D. Searle & Company Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
CN1253474A (zh) * 1997-03-04 2000-05-17 孟山都公司 磺酰基二价芳基或杂芳基异羟肟酸化合物
JP2001524462A (ja) * 1997-11-21 2001-12-04 ファーマシア・アンド・アップジョン・カンパニー マトリックスメタロプロテイナーゼインヒビターとしてのβ−スルホニルヒドロキサム酸のα−ヒドロキシ、−アミノ及びハロ誘導体

Also Published As

Publication number Publication date
WO1999026909A2 (en) 1999-06-03
CA2310401A1 (en) 1999-06-03
CN1278247A (zh) 2000-12-27
PT1037868E (pt) 2003-06-30
AU763113B2 (en) 2003-07-10
BG104346A (en) 2001-01-31
US20030166687A1 (en) 2003-09-04
HUP0100812A2 (hu) 2001-08-28
EP1037868B1 (en) 2003-02-05
HUP0100812A3 (en) 2002-11-28
ATE232192T1 (de) 2003-02-15
NO20002505L (no) 2000-06-30
NO20002505D0 (no) 2000-05-15
PL341153A1 (en) 2001-03-26
TR200001391T2 (tr) 2000-11-21
DE69811273T2 (de) 2003-12-11
AU2540599A (en) 1999-06-15
ES2192349T3 (es) 2003-10-01
DE69811273D1 (de) 2003-03-13
US6437177B1 (en) 2002-08-20
EP1037868A2 (en) 2000-09-27
UA66818C2 (uk) 2004-06-15
KR20010032319A (ko) 2001-04-16
EA003585B1 (ru) 2003-06-26
WO1999026909A3 (en) 1999-08-26
IS5475A (is) 2000-04-28
IL135586A0 (en) 2001-05-20
EA200000551A1 (ru) 2000-10-30
DK1037868T3 (da) 2003-05-12
CN1168709C (zh) 2004-09-29
IS1954B (is) 2004-10-13
JP2001524462A (ja) 2001-12-04
NZ503997A (en) 2001-09-28

Similar Documents

Publication Publication Date Title
BR9814699A (pt) Derivados alfa-hidróxi, amino e halo de ácidos beta-sulfonil hidroxâmico como inibidores de metaloproteinases matrizes
BRPI0511186A (pt) composto, pró-droga do composto, composição farmacêutica, uso do composto, e, processo para preparar o composto
DE69310501T2 (de) Chinolylbenzofuran derivate als leukotrien-antagonisten
BR0207268A (pt) Quinazolinas como inibidores de mmp-13
BR0212726A (pt) Compostos que contém lactamas, e derivados dos mesmos, como inibidores do fator xa
ATE286026T1 (de) Amid-derivate und deren medizinische verwendung
DE60033857D1 (de) Derivate des N-((Chinolinyl)oxy)-phenyl)-Harnstoffs und des N-((Chinazolinyl)oxy)-phenyl)-Harnstoffs mit Antitumor Aktivität
EA200300531A1 (ru) Производные фталазинона
BRPI0008753B8 (pt) composto de amida, processo para preparar um composto de amida, composição farmacêutica e uso de um composto de amida
PT95202A (pt) Processo para a preparacao de n-substituidas-4-pirimidinaminas e de composicoes farmaceuticas que os contem
DK2174936T3 (da) Pna-monomer og prækursor
BRPI0407695A (pt) compostos, processo para a preparação de um composto, composições farmacêuticas que compreendem o composto, utilização dos compostos e processo de tratamento para diabetes do tipo 2
BRPI0416450A (pt) derivados de ácido fosfìnico, inibidores de beta - secretase para o tratamento de mal de alzheimer
BRPI0111142C1 (pt) utilização de derivados de biguanida ou sais farmaceuticamente aceitáveis dos mesmos para fabricação de medicamento tendo um efeito cicatrizante
DE60221348D1 (de) Substituierte chinoline zur behandlung von durch protozoen und retroviren verursachten co-infektionen
BR9407077A (pt) Derivados de 3-arilpirazóis processo de preparação de derivados processo de preparação de sais de amònio substituído ou de imidínio substituído composições de proteção de plantas contra doenças fúngicas e compostos
BR0110519A (pt) Método para inibir a agregação de proteìnas amilóides e formar imagens dos depósitos de amilóides usando derivados de aminoindano
BR0215067A (pt) Piridoquinoxalinas antivirais
FI920435A0 (fi) N-(aryloxyalkyl) heteroaryl-8 -azabicyclo/3.2.1./oktaner, mellanprodukter och deras framstaellnings -foerfarande och deras anvaendning som laekemedel.
WO1998052917A3 (en) Guanidinylation reagents
BR9711189A (pt) Processo para a prepara-Æo de n-¬(1 butil-4-piperdil) metil¾-3,4-diidro-2h-¬1,3-oc¾indol-10-carboxamida e sais e intermediarios no processo (57) &#34;processo para a prepara-Æo de n-¬(1-nbutil-4-piperdil) metil¾-3,4-diiro-2h--1-3-¾indol-1 0-carboxamida e sais e intermedi rios no processo a presente inven-Æo refere-se prepara-Æo de sb207266 ou um seu sal farmaceuticamente aceit vel cujo processo compreende a rea-Æo de n-(1-nbutil-4-piperidilmetil amina com um composto de fÄrmula (a) em que r e alqu
BRPI0401031A (pt) Compostos de isoquinolina, processo para sua preparação e composições farmacêuticas contendo os mesmos
BR0215080A (pt) Composto inibidores de lipase pancreática, sua sìntese e uso
ATE293616T1 (de) 2-fluoro-(oxido-thiopyran-4-yl)benzol derivate
BR0202686A (pt) Compostos de n-benzilpiperazina, processo para sua preparação e composições farmacêuticas contendo os mesmos

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.8: C07C 317/32, C07C 317/44, A61K 31/10, A61P 1/04, A61P 17/02, A61P 19/02, A61P 19/04, A61P 19/10, A61P 35/04

Ipc: C07C 317/32 (2007.10), C07C 317/44 (2007.10), A61K

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements