DE69811273D1 - Alpha-hydroxy, -amino und -fluoro derivate von beta-sulfonylhydroxamsäuren als matrixmetalloproteinasen-inhibitoren - Google Patents

Alpha-hydroxy, -amino und -fluoro derivate von beta-sulfonylhydroxamsäuren als matrixmetalloproteinasen-inhibitoren

Info

Publication number
DE69811273D1
DE69811273D1 DE69811273T DE69811273T DE69811273D1 DE 69811273 D1 DE69811273 D1 DE 69811273D1 DE 69811273 T DE69811273 T DE 69811273T DE 69811273 T DE69811273 T DE 69811273T DE 69811273 D1 DE69811273 D1 DE 69811273D1
Authority
DE
Germany
Prior art keywords
unsubstituted
substituted
inhibitors
oprotein
nose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69811273T
Other languages
English (en)
Other versions
DE69811273T2 (de
Inventor
A Warpehoski
Allen Mitchell
E Harper
Louise Maggiora
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of DE69811273D1 publication Critical patent/DE69811273D1/de
Publication of DE69811273T2 publication Critical patent/DE69811273T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
DE69811273T 1997-11-21 1998-11-18 Alpha-hydroxy, -amino und -fluoro derivate von beta-sulfonylhydroxamsäuren als matrixmetalloproteinasen-inhibitoren Expired - Fee Related DE69811273T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7265597P 1997-11-21 1997-11-21
PCT/IB1998/002154 WO1999026909A2 (en) 1997-11-21 1998-11-18 Alpha-hydroxy, -amino and -fluoro derivatives of beta-sulphonyl hydroxamic acids as matrix metalloproteinases inhibitors

Publications (2)

Publication Number Publication Date
DE69811273D1 true DE69811273D1 (de) 2003-03-13
DE69811273T2 DE69811273T2 (de) 2003-12-11

Family

ID=22108985

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811273T Expired - Fee Related DE69811273T2 (de) 1997-11-21 1998-11-18 Alpha-hydroxy, -amino und -fluoro derivate von beta-sulfonylhydroxamsäuren als matrixmetalloproteinasen-inhibitoren

Country Status (24)

Country Link
US (2) US20030166687A1 (de)
EP (1) EP1037868B1 (de)
JP (1) JP2001524462A (de)
KR (1) KR20010032319A (de)
CN (1) CN1168709C (de)
AT (1) ATE232192T1 (de)
AU (1) AU763113B2 (de)
BG (1) BG104346A (de)
BR (1) BR9814699A (de)
CA (1) CA2310401A1 (de)
DE (1) DE69811273T2 (de)
DK (1) DK1037868T3 (de)
EA (1) EA003585B1 (de)
ES (1) ES2192349T3 (de)
HU (1) HUP0100812A3 (de)
IL (1) IL135586A0 (de)
IS (1) IS1954B (de)
NO (1) NO20002505L (de)
NZ (1) NZ503997A (de)
PL (1) PL341153A1 (de)
PT (1) PT1037868E (de)
TR (1) TR200001391T2 (de)
UA (1) UA66818C2 (de)
WO (1) WO1999026909A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001524462A (ja) * 1997-11-21 2001-12-04 ファーマシア・アンド・アップジョン・カンパニー マトリックスメタロプロテイナーゼインヒビターとしてのβ−スルホニルヒドロキサム酸のα−ヒドロキシ、−アミノ及びハロ誘導体
GB9927453D0 (en) * 1999-11-19 2000-01-19 Pharmacia & Upjohn Spa Crystalline and optically active form of a-hydroxy derivatives of ›-sulfonyl acid
WO2002030879A2 (en) 2000-09-29 2002-04-18 Prolifix Limited Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors
DE60138658D1 (de) * 2000-09-29 2009-06-18 Topotarget Uk Ltd Carbaminsäurederivate enthaltend eine Amidgruppe zur Behandlung von Malaria
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
WO2007070760A2 (en) * 2005-12-15 2007-06-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2081905B1 (de) * 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl verbindungen als cb2 rezeptor modulatoren
JP5030114B2 (ja) * 2006-09-25 2012-09-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体をモジュレートする化合物
US7539361B2 (en) * 2006-10-05 2009-05-26 Harris Corporation Fiber optic device for measuring a parameter of interest
DE102006049618A1 (de) * 2006-10-20 2008-05-08 Tschesche, Harald, Prof. Dr. Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren
EP2217565B1 (de) * 2007-11-07 2013-05-22 Boehringer Ingelheim International GmbH Cb2 rezeptor-modulierende verbindungen
US8178568B2 (en) * 2008-07-10 2012-05-15 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the CB2 receptor
KR20110063438A (ko) * 2008-09-25 2011-06-10 베링거 인겔하임 인터내셔날 게엠베하 Ｃｂ2 수용체를 선택적으로 조절하는 설포닐 화합물
US8299103B2 (en) * 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
JP2013505295A (ja) * 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
JP2013517271A (ja) 2010-01-15 2013-05-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
JP5746228B2 (ja) 2010-03-05 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節するテトラゾール化合物
US8846936B2 (en) 2010-07-22 2014-09-30 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the CB2 receptor
EP2803668A1 (de) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole
DK3013796T3 (da) * 2013-06-27 2020-03-16 Lg Chemical Ltd Biarylderivater som gpr120-agonister
RU2748835C1 (ru) 2017-11-27 2021-05-31 Совет Научных И Прикладных Исследований Индол(сульфонил)-n-гидроксибензамидные производные в качестве селективных ингибиторов hdac

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE225343T1 (de) * 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
DK0871439T3 (da) 1996-01-02 2004-08-02 Aventis Pharma Inc Substituerede (aryl, heteroaryl, arylmethyl eller heteroarylmethyl) hydroxamsyreforbindelser
KR20000022532A (ko) 1996-06-27 2000-04-25 오노 야꾸힝 고교 가부시키가이샤 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물
DE69729007T2 (de) 1996-08-07 2005-04-07 Darwin Discovery Ltd., Slough Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
CZ92399A3 (cs) * 1996-09-27 1999-07-14 Pharmacia & Upjohn Company ß-sulfonylhydroxamové kyseliny jako inhibitory matriční metaloproteinázy
AU5337498A (en) * 1997-01-22 1998-08-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted beta-thiocarboxylic acids
AU5493598A (en) 1997-02-07 1998-08-26 Pfizer Inc. N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
US6362183B1 (en) * 1997-03-04 2002-03-26 G. D. Searle & Company Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
CN1253474A (zh) * 1997-03-04 2000-05-17 孟山都公司 磺酰基二价芳基或杂芳基异羟肟酸化合物
JP2001524462A (ja) * 1997-11-21 2001-12-04 ファーマシア・アンド・アップジョン・カンパニー マトリックスメタロプロテイナーゼインヒビターとしてのβ−スルホニルヒドロキサム酸のα−ヒドロキシ、−アミノ及びハロ誘導体

Also Published As

Publication number Publication date
WO1999026909A2 (en) 1999-06-03
CA2310401A1 (en) 1999-06-03
CN1278247A (zh) 2000-12-27
PT1037868E (pt) 2003-06-30
AU763113B2 (en) 2003-07-10
BG104346A (en) 2001-01-31
US20030166687A1 (en) 2003-09-04
HUP0100812A2 (hu) 2001-08-28
EP1037868B1 (de) 2003-02-05
HUP0100812A3 (en) 2002-11-28
ATE232192T1 (de) 2003-02-15
NO20002505L (no) 2000-06-30
NO20002505D0 (no) 2000-05-15
PL341153A1 (en) 2001-03-26
TR200001391T2 (tr) 2000-11-21
DE69811273T2 (de) 2003-12-11
AU2540599A (en) 1999-06-15
ES2192349T3 (es) 2003-10-01
US6437177B1 (en) 2002-08-20
EP1037868A2 (de) 2000-09-27
UA66818C2 (uk) 2004-06-15
KR20010032319A (ko) 2001-04-16
EA003585B1 (ru) 2003-06-26
WO1999026909A3 (en) 1999-08-26
IS5475A (is) 2000-04-28
IL135586A0 (en) 2001-05-20
BR9814699A (pt) 2000-10-03
EA200000551A1 (ru) 2000-10-30
DK1037868T3 (da) 2003-05-12
CN1168709C (zh) 2004-09-29
IS1954B (is) 2004-10-13
JP2001524462A (ja) 2001-12-04
NZ503997A (en) 2001-09-28

Similar Documents

Publication Publication Date Title
DE69811273D1 (de) Alpha-hydroxy, -amino und -fluoro derivate von beta-sulfonylhydroxamsäuren als matrixmetalloproteinasen-inhibitoren
EA199900332A1 (ru) β-СУЛЬФОНИЛ ГИДРОКСАМОВЫЕ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ МАТРИЧНЫХ МЕТАЛЛОПРОТЕИНАЗ
MX9202142A (es) Nuevos derivados de urea, proceso para su preparacion, y composicion farmaceutica que los comprende.
ES2176204T3 (es) Antidepresivos que contienen un derivado de xantina.
BR9915727A (pt) ésteres derivados de compostos de fenil-ciclohexila substituìdos
ATE152719T1 (de) Chinolylbenzofuran derivate als leukotrien- antagonisten
CO4950553A1 (es) Compuestos de 7-tetrahidroisoquinolinas y procedimiento para su preparacion
AR006360A1 (es) Derivados de 1,2,3,4-tetrahidronaftaleno substituidos, uso de los mismos para la preparacion de medicamentos y procedimiento para su preparacion.
EA199800170A1 (ru) Производные 2-(4-замещенного)бензиламино-2-метилпропанамида
AR012603A1 (es) Inhibidor de proteasa, composicion farmaceutica que lo comprende y el uso del mismo para la fabricacion de un medicamento; e intermediarios de sintesis
KR900007790A (ko) 항-아테롬성 동맥경화증성 디아릴 화합물
FI920435A0 (fi) N-(aryloxyalkyl) heteroaryl-8 -azabicyclo/3.2.1./oktaner, mellanprodukter och deras framstaellnings -foerfarande och deras anvaendning som laekemedel.
BR0110519A (pt) Método para inibir a agregação de proteìnas amilóides e formar imagens dos depósitos de amilóides usando derivados de aminoindano
BR9812085A (pt) "método para a sìntese de derivados de quinolina"
PL306538A1 (en) Substituted (aryloalkylaminobenzyl) amino propanamide derivatives, method of obtaining them and their application as antiepileptic, nervous system protecting and antidepressive agents
ATE293616T1 (de) 2-fluoro-(oxido-thiopyran-4-yl)benzol derivate
CO4700450A1 (es) Nuevos azepanos y homologos de su anillo
BR9813775A (pt) Uso de um composto, processo para o tratamento de uma condição de cefaléia vascular, e, composição farmacêutica adequada para uso no tratamento de uma condição de cefaléia vascular.
AR029375A1 (es) DERIVADOS DE CARBOXAMIDA, UN PROCEDIMIENTO PARA SU PREPARACIoN, UNA COMPOSICIoN FARMACEUTICA QUE LOS COMPRENDE Y EL USO DE DICHO DERIVADO PARA LA FABRICACION DE UN MEDICAMENTO
KR950703579A (ko) 우레이도아세트아미드 유도체, 그들의 제조 및 상기를 함유하는 약제(urei-do-acetamide derivatives, preparation thereof and drugs con-taining same)
UY27239A1 (es) Nuevos derivados de pirimidín-2,4,6-triona, procedimiento para su producción y agentes farmaceúticos que contienen estos compuestos.
TH25498A (th) สารประกอบเบนโซไธโอฟีน,สารขั้นกลาง,องค์ประกอบและวิธี
BR9902748A (pt) Sìntese e atividade antileishmanìase de derivados de n,n-dimetil-2-propen-1-amina

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee