BR9811531A - Preparação de proteìnas mutadas humanas em células humanas por meio de recombinação homóloga - Google Patents
Preparação de proteìnas mutadas humanas em células humanas por meio de recombinação homólogaInfo
- Publication number
- BR9811531A BR9811531A BR9811531-6A BR9811531A BR9811531A BR 9811531 A BR9811531 A BR 9811531A BR 9811531 A BR9811531 A BR 9811531A BR 9811531 A BR9811531 A BR 9811531A
- Authority
- BR
- Brazil
- Prior art keywords
- human
- preparation
- homologous recombination
- human cells
- cells
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 5
- 210000005260 human cell Anatomy 0.000 title abstract 4
- 230000006801 homologous recombination Effects 0.000 title abstract 2
- 238000002744 homologous recombination Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 102000003839 Human Proteins Human genes 0.000 abstract 2
- 108090000144 Human Proteins Proteins 0.000 abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
- 238000005215 recombination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112639 | 1997-07-23 | ||
| PCT/EP1998/004583 WO1999005264A2 (de) | 1997-07-23 | 1998-07-22 | Herstellung humaner mutierter proteine in humanen zellen mittels homologer rekombination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9811531A true BR9811531A (pt) | 2000-08-22 |
Family
ID=8227102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9811531-6A BR9811531A (pt) | 1997-07-23 | 1998-07-22 | Preparação de proteìnas mutadas humanas em células humanas por meio de recombinação homóloga |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6444441B1 (enExample) |
| EP (1) | EP1000167B2 (enExample) |
| JP (1) | JP2001511341A (enExample) |
| KR (1) | KR100512018B1 (enExample) |
| CN (2) | CN101348789B (enExample) |
| AR (2) | AR013251A1 (enExample) |
| AT (1) | ATE313643T1 (enExample) |
| AU (1) | AU729489B2 (enExample) |
| BR (1) | BR9811531A (enExample) |
| CA (1) | CA2297660C (enExample) |
| DE (1) | DE59813296D1 (enExample) |
| DK (1) | DK1000167T4 (enExample) |
| ES (1) | ES2255177T5 (enExample) |
| PT (1) | PT1000167E (enExample) |
| TR (1) | TR200000172T2 (enExample) |
| WO (1) | WO1999005264A2 (enExample) |
| ZA (1) | ZA986517B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102789754B1 (ko) * | 2016-01-06 | 2025-03-31 | 론자 리미티드 | 개선된 생산을 위한 단백질 분해의 억제 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234686A (en) * | 1985-04-03 | 1993-08-10 | Beecham Group P.L.C. | Human tissue plasminogen activator consisting essentially of t-PA residues to 160 to 527, pharmaceutical compositions and methods of treatment |
| US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
| DE3903581A1 (de) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | Gewebs-plasminogenaktivator-derivat |
| DE3907679A1 (de) * | 1989-03-09 | 1990-09-13 | Max Planck Gesellschaft | Verfahren zur gezielten veraenderung eines gens |
| JPH0576361A (ja) * | 1990-05-10 | 1993-03-30 | Takeda Chem Ind Ltd | 組織プラスミノーゲンアクチベータームテイン |
| US5612205A (en) | 1990-08-29 | 1997-03-18 | Genpharm International, Incorporated | Homologous recombination in mammalian cells |
| WO1992020808A1 (en) * | 1991-05-15 | 1992-11-26 | Cell Genesys, Inc. | Genomic modifications with homologous dna targeting |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| DE69333955D1 (de) * | 1992-04-24 | 2006-02-02 | Stanford Res Inst Int | Targeting homologer sequenzen in eukaryotenzellen |
| WO1994004032A1 (en) * | 1992-08-21 | 1994-03-03 | The Regents Of The University Of California | Composition and method for altering dna sequences by homologous recombination |
| TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| CN1256986C (zh) * | 1993-12-02 | 2006-05-24 | 转移染色体治疗公司 | 蛋白质的生产和蛋白质的输送 |
| AU6328696A (en) * | 1995-06-07 | 1996-12-30 | Yale University | Treatment of hemoglobinopathies |
| US6087129A (en) * | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
-
1998
- 1998-07-22 WO PCT/EP1998/004583 patent/WO1999005264A2/de not_active Ceased
- 1998-07-22 ES ES98942591T patent/ES2255177T5/es not_active Expired - Lifetime
- 1998-07-22 AT AT98942591T patent/ATE313643T1/de active
- 1998-07-22 PT PT98942591T patent/PT1000167E/pt unknown
- 1998-07-22 DK DK98942591.3T patent/DK1000167T4/da active
- 1998-07-22 JP JP2000504239A patent/JP2001511341A/ja active Pending
- 1998-07-22 BR BR9811531-6A patent/BR9811531A/pt not_active Application Discontinuation
- 1998-07-22 KR KR10-2000-7000697A patent/KR100512018B1/ko not_active Expired - Lifetime
- 1998-07-22 CA CA2297660A patent/CA2297660C/en not_active Expired - Lifetime
- 1998-07-22 US US09/463,338 patent/US6444441B1/en not_active Expired - Lifetime
- 1998-07-22 CN CN200810130044.0A patent/CN101348789B/zh not_active Expired - Lifetime
- 1998-07-22 TR TR2000/00172T patent/TR200000172T2/xx unknown
- 1998-07-22 EP EP98942591A patent/EP1000167B2/de not_active Expired - Lifetime
- 1998-07-22 CN CN98807438A patent/CN1265152A/zh active Pending
- 1998-07-22 DE DE59813296T patent/DE59813296D1/de not_active Expired - Lifetime
- 1998-07-22 ZA ZA9806517A patent/ZA986517B/xx unknown
- 1998-07-22 AU AU90673/98A patent/AU729489B2/en not_active Expired
- 1998-07-23 AR ARP980103617A patent/AR013251A1/es active IP Right Grant
-
2002
- 2002-07-15 US US10/194,244 patent/US20020177195A1/en not_active Abandoned
-
2008
- 2008-08-20 AR ARP080103620A patent/AR068104A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU9067398A (en) | 1999-02-16 |
| AR013251A1 (es) | 2000-12-13 |
| US20020068318A1 (en) | 2002-06-06 |
| ATE313643T1 (de) | 2006-01-15 |
| EP1000167B1 (de) | 2005-12-21 |
| DK1000167T3 (da) | 2006-04-24 |
| PT1000167E (pt) | 2006-05-31 |
| DE59813296D1 (de) | 2006-01-26 |
| CN101348789B (zh) | 2016-08-17 |
| ES2255177T3 (es) | 2006-06-16 |
| US6444441B1 (en) | 2002-09-03 |
| CN1265152A (zh) | 2000-08-30 |
| EP1000167A2 (de) | 2000-05-17 |
| EP1000167B2 (de) | 2011-04-20 |
| WO1999005264A2 (de) | 1999-02-04 |
| CN101348789A (zh) | 2009-01-21 |
| TR200000172T2 (tr) | 2000-12-21 |
| KR100512018B1 (ko) | 2005-09-02 |
| CA2297660C (en) | 2010-04-27 |
| ES2255177T5 (es) | 2011-07-12 |
| KR20010022127A (ko) | 2001-03-15 |
| US20020177195A1 (en) | 2002-11-28 |
| ZA986517B (en) | 2000-01-24 |
| AR068104A2 (es) | 2009-11-04 |
| AU729489B2 (en) | 2001-02-01 |
| CA2297660A1 (en) | 1999-02-04 |
| JP2001511341A (ja) | 2001-08-14 |
| WO1999005264A3 (de) | 1999-04-22 |
| DK1000167T4 (da) | 2011-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9814404A (pt) | " clonagem de expressão em fungos filamentosos " | |
| ES2147553T3 (es) | Vectores virales recombinantes para la expresion en unas celulas musculares. | |
| AU2001278797A1 (en) | Expression vector using for animal cell | |
| BRPI0412799A (pt) | imunógeno, composição, ácido nucleico, célula recombinante, métodos para preparar um polipeptìdeo, para induzir um a resposta imune protetora em um paciente e para induzir uma resposta anamnésica em um paciente, e, seqüência de ácido nucleico otimizada de levedura | |
| DK58789D0 (da) | Proteiner med faktor viii-aktivitet, fremgangsmaade til deres fremstilling ved anvendelse af genetisk konstruerede celler og farmaceutiske kompositioner indeholdende proteinerne | |
| ATE404583T1 (de) | Funktionelle antagonisten von hedgehog-aktivität | |
| PT93910A (pt) | Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula | |
| DK1200583T3 (da) | Fremstilling af beta-foldeblad-proteiner med specifikke bindingsegenskaber | |
| BR9812547A (pt) | Proteìnas de fusão compreendendo proteìnas hiv-1 tat e/ou nef | |
| DE69516847D1 (de) | Chlorpyrimidine als zwischenprodukte | |
| ATE112687T1 (de) | Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen. | |
| BR9712556A (pt) | Plasmìdeo, composição farmacêutica, e, processo de imunizar um indivìduo contra um antìgeno | |
| ATE437951T1 (de) | Intrazelluläre herstellung von verkürztem hepatitis c-polypeptid e2 | |
| DE69505804D1 (de) | Afamin: ein menschliches serum albumin ähnliches protein | |
| DK0851926T3 (da) | Varianter af humant rekombinant gamminterferon (rhu-IFN-gamma) med forøget termisk stabilitet | |
| DK124787A (da) | Peptider indeholdende op til 8-aminosyregrupperinger og fysiologisk uskadelige salte deraf, deres fremstilling og anvendelse som laegemidler samt mellemprodukter ved fremstillingen | |
| NO984491D0 (no) | SCF-analogpreparater og fremgangsmÕte for fremstilling av disse | |
| WO1994003601A3 (en) | Cloning, expression and uses for neurocan as a chondroitin sulfate proteoglycan | |
| EA200000270A1 (ru) | КОМПОЗИЦИИ ДЛЯ ГЕНОТЕРАПИИ С ИСПОЛЬЗОВАНИЕМ ГЕНОВ, КОДИРУЮЩИХ СЕКРЕТИРУЕМЫЕ БЕЛКИ, ТАКИЕ КАК β-ИНТЕРФЕРОН, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| BR9811531A (pt) | Preparação de proteìnas mutadas humanas em células humanas por meio de recombinação homóloga | |
| EP0770137A4 (en) | IMPROVEMENTS IN PROTEIN PRODUCTION IN HOST CELLS | |
| DE59712771D1 (de) | Nebenhoden-spezifisches Rezeptorprotein und dessen Verwendung | |
| BR0303362A (pt) | Composição e método para melhorar uma resposta imune em um animal, método para distribuir uma proteìna de carga em uma célula de animal, célula viva geneticamente modificada, e, método para a construção de uma proteìna de fusão para melhorar a resposta imune em um animal | |
| ATE399794T1 (de) | Modifizierter granulozyten stimulierender factor (g-csf) mit verringerter immunogenität | |
| AR034853A1 (es) | Secuencia de acido nucleico sintetico que codifica una alfa-galactosidasa, vector y celula que la comprenden, metodo para producir alfa-galactosidasa, metodo para prepararla, composicion farmaceutica que comprende dicha secuencia y su uso para preparar esta ultima |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: COM BASE NO ART. 8O COMBINADO COM ART. 13 DA LPI 9279/96 E DE ACORDO COM O ART. 37 DA LPI, SUGERE-SE O INDEFERIMENTO DO PRESENTE PEDIDO DE PATENTE. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |