AR013251A1 - PROCEDIMIENTO PARA LA PRODUCCION DE MUTEíNAS DE POLIPÉPTIDOS EUCARIoTICOS, PROCEDIMIENTO PARA LA PRODUCCIoN DE UNA CÉLULA HUMANA, QUE NO DE LUGAR A UN INIDIVIDUO COMPLETO, QUE EXPRESA UNA MUTEíNA DE UN POLIPÉPTIDO BLANCO HUMANO, CÉLULA HUMANA OBTENIBLE MEDIANTE DICHO PROCESO Y USO DE DICHA CÉLULA HU - Google Patents
PROCEDIMIENTO PARA LA PRODUCCION DE MUTEíNAS DE POLIPÉPTIDOS EUCARIoTICOS, PROCEDIMIENTO PARA LA PRODUCCIoN DE UNA CÉLULA HUMANA, QUE NO DE LUGAR A UN INIDIVIDUO COMPLETO, QUE EXPRESA UNA MUTEíNA DE UN POLIPÉPTIDO BLANCO HUMANO, CÉLULA HUMANA OBTENIBLE MEDIANTE DICHO PROCESO Y USO DE DICHA CÉLULA HUInfo
- Publication number
- AR013251A1 AR013251A1 ARP980103617A ARP980103617A AR013251A1 AR 013251 A1 AR013251 A1 AR 013251A1 AR P980103617 A ARP980103617 A AR P980103617A AR P980103617 A ARP980103617 A AR P980103617A AR 013251 A1 AR013251 A1 AR 013251A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- production
- muteins
- inidividuo
- eucharitic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un procedimiento para la preparacion de muteínas de polipéptidos eucariotas en células eucariotas por medio de recombinacion homologa. Además,un procedimiento para la preparacion de células humanas, las cuales son adecuadas parala preparacion de proteínas mutadas humanas. Finalmente,células humanas preparadas de acuerdo con el procedimiento y las proteínas humanas mutadas que se pueden obtener por el mismo, así como tambiénpreparados farmacéuticos que contienen estasmut eínas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97112639 | 1997-07-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR013251A1 true AR013251A1 (es) | 2000-12-13 |
Family
ID=8227102
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980103617A AR013251A1 (es) | 1997-07-23 | 1998-07-23 | PROCEDIMIENTO PARA LA PRODUCCION DE MUTEíNAS DE POLIPÉPTIDOS EUCARIoTICOS, PROCEDIMIENTO PARA LA PRODUCCIoN DE UNA CÉLULA HUMANA, QUE NO DE LUGAR A UN INIDIVIDUO COMPLETO, QUE EXPRESA UNA MUTEíNA DE UN POLIPÉPTIDO BLANCO HUMANO, CÉLULA HUMANA OBTENIBLE MEDIANTE DICHO PROCESO Y USO DE DICHA CÉLULA HU |
ARP080103620A AR068104A2 (es) | 1997-07-23 | 2008-08-20 | Procedimiento in vitro para la produccion de muteinas de polipeptidos eucarioticos ; procedimiento in vitro para la obtencion de una celula humana que expresa una muteina de un polipeptido blanco humano. celula humana obtenible por dicho procedimiento y uso de dicha celula humana |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080103620A AR068104A2 (es) | 1997-07-23 | 2008-08-20 | Procedimiento in vitro para la produccion de muteinas de polipeptidos eucarioticos ; procedimiento in vitro para la obtencion de una celula humana que expresa una muteina de un polipeptido blanco humano. celula humana obtenible por dicho procedimiento y uso de dicha celula humana |
Country Status (17)
Country | Link |
---|---|
US (2) | US6444441B1 (es) |
EP (1) | EP1000167B2 (es) |
JP (1) | JP2001511341A (es) |
KR (1) | KR100512018B1 (es) |
CN (2) | CN101348789B (es) |
AR (2) | AR013251A1 (es) |
AT (1) | ATE313643T1 (es) |
AU (1) | AU729489B2 (es) |
BR (1) | BR9811531A (es) |
CA (1) | CA2297660C (es) |
DE (1) | DE59813296D1 (es) |
DK (1) | DK1000167T4 (es) |
ES (1) | ES2255177T5 (es) |
PT (1) | PT1000167E (es) |
TR (1) | TR200000172T2 (es) |
WO (1) | WO1999005264A2 (es) |
ZA (1) | ZA986517B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL260369B2 (en) * | 2016-01-06 | 2024-03-01 | Lonza Ag | Inhibition of protein breakdown for improved production |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234686A (en) * | 1985-04-03 | 1993-08-10 | Beecham Group P.L.C. | Human tissue plasminogen activator consisting essentially of t-PA residues to 160 to 527, pharmaceutical compositions and methods of treatment |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
DE3903581A1 (de) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | Gewebs-plasminogenaktivator-derivat |
DE3907679A1 (de) * | 1989-03-09 | 1990-09-13 | Max Planck Gesellschaft | Verfahren zur gezielten veraenderung eines gens |
JPH0576361A (ja) * | 1990-05-10 | 1993-03-30 | Takeda Chem Ind Ltd | 組織プラスミノーゲンアクチベータームテイン |
EP0546091B1 (en) | 1990-08-29 | 2007-01-24 | Pharming Intellectual Property BV | Homologous recombination in mammalian cells |
AU664847B2 (en) | 1991-05-15 | 1995-12-07 | Cell Genesys, Inc. | Genomic modifications with homologous DNA targeting |
US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
CA2118513A1 (en) * | 1992-04-24 | 1993-11-11 | David A. Zarling | In vivo homologous sequence targeting in eukaryotic cells |
AU5087193A (en) * | 1992-08-21 | 1994-03-15 | Regents Of The University Of California, The | Composition and method for altering dna sequences by homologous recombination |
TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
CN1256986C (zh) * | 1993-12-02 | 2006-05-24 | 转移染色体治疗公司 | 蛋白质的生产和蛋白质的输送 |
AU6328696A (en) * | 1995-06-07 | 1996-12-30 | Yale University | Treatment of hemoglobinopathies |
US6087129A (en) * | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
-
1998
- 1998-07-22 CN CN200810130044.0A patent/CN101348789B/zh not_active Expired - Lifetime
- 1998-07-22 AU AU90673/98A patent/AU729489B2/en not_active Expired
- 1998-07-22 KR KR10-2000-7000697A patent/KR100512018B1/ko not_active IP Right Cessation
- 1998-07-22 CA CA2297660A patent/CA2297660C/en not_active Expired - Lifetime
- 1998-07-22 US US09/463,338 patent/US6444441B1/en not_active Expired - Lifetime
- 1998-07-22 DK DK98942591.3T patent/DK1000167T4/da active
- 1998-07-22 ES ES98942591T patent/ES2255177T5/es not_active Expired - Lifetime
- 1998-07-22 JP JP2000504239A patent/JP2001511341A/ja active Pending
- 1998-07-22 AT AT98942591T patent/ATE313643T1/de active
- 1998-07-22 CN CN98807438A patent/CN1265152A/zh active Pending
- 1998-07-22 BR BR9811531-6A patent/BR9811531A/pt not_active Application Discontinuation
- 1998-07-22 EP EP98942591A patent/EP1000167B2/de not_active Expired - Lifetime
- 1998-07-22 WO PCT/EP1998/004583 patent/WO1999005264A2/de active IP Right Grant
- 1998-07-22 PT PT98942591T patent/PT1000167E/pt unknown
- 1998-07-22 TR TR2000/00172T patent/TR200000172T2/xx unknown
- 1998-07-22 ZA ZA9806517A patent/ZA986517B/xx unknown
- 1998-07-22 DE DE59813296T patent/DE59813296D1/de not_active Expired - Lifetime
- 1998-07-23 AR ARP980103617A patent/AR013251A1/es active IP Right Grant
-
2002
- 2002-07-15 US US10/194,244 patent/US20020177195A1/en not_active Abandoned
-
2008
- 2008-08-20 AR ARP080103620A patent/AR068104A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES2255177T5 (es) | 2011-07-12 |
BR9811531A (pt) | 2000-08-22 |
CN101348789B (zh) | 2016-08-17 |
KR20010022127A (ko) | 2001-03-15 |
AU9067398A (en) | 1999-02-16 |
EP1000167B2 (de) | 2011-04-20 |
WO1999005264A3 (de) | 1999-04-22 |
DK1000167T4 (da) | 2011-08-08 |
US20020068318A1 (en) | 2002-06-06 |
EP1000167B1 (de) | 2005-12-21 |
PT1000167E (pt) | 2006-05-31 |
ATE313643T1 (de) | 2006-01-15 |
CA2297660C (en) | 2010-04-27 |
KR100512018B1 (ko) | 2005-09-02 |
DE59813296D1 (de) | 2006-01-26 |
JP2001511341A (ja) | 2001-08-14 |
US6444441B1 (en) | 2002-09-03 |
EP1000167A2 (de) | 2000-05-17 |
TR200000172T2 (tr) | 2000-12-21 |
AR068104A2 (es) | 2009-11-04 |
WO1999005264A2 (de) | 1999-02-04 |
AU729489B2 (en) | 2001-02-01 |
ZA986517B (en) | 2000-01-24 |
ES2255177T3 (es) | 2006-06-16 |
CA2297660A1 (en) | 1999-02-04 |
CN101348789A (zh) | 2009-01-21 |
CN1265152A (zh) | 2000-08-30 |
US20020177195A1 (en) | 2002-11-28 |
DK1000167T3 (da) | 2006-04-24 |
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Legal Events
Date | Code | Title | Description |
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FG | Grant, registration |