BR9811262A - Composições auxiliares imunológicas aquosas de lipìdio de monofosforila a. - Google Patents

Composições auxiliares imunológicas aquosas de lipìdio de monofosforila a.

Info

Publication number
BR9811262A
BR9811262A BR9811262-7A BR9811262A BR9811262A BR 9811262 A BR9811262 A BR 9811262A BR 9811262 A BR9811262 A BR 9811262A BR 9811262 A BR9811262 A BR 9811262A
Authority
BR
Brazil
Prior art keywords
lipid
surfactant
aqueous
derivative
auxiliary
Prior art date
Application number
BR9811262-7A
Other languages
English (en)
Inventor
R Thomas Crane
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of BR9811262A publication Critical patent/BR9811262A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçõES AUXILIARES IMUNOLóGICAS AQUOSAS DE LIPìDIO DE MONOFOSFORILA A"<D>. Uma composição auxiliar aquosa que compreende um derivado de lipídio A atenuado e um tensoativo ou tensoativos melhora a resposta imunológica em um animal de sangue quente a um antígeno de proteína. Os derivados de lipídio A atenuado úteis de acordo com a invenção em questão incluem lipídio de monofosforila A e lipídio de monofosforila A 3-O-desacilada. Um tensoativo ou misturas de tensoativos são dissolvidos em um solvente. 1,2-Dipalmitoil-sn-glícero-3-fosfocolina é um solvente preferido. O tensoativo dissolvido é adicionado a um derivado de lipídio A atenuado para obter uma mistura. A razão molar de derivado de lipídio A atenuado para tensoativo na mistura é aproximadamente 4:1. O solvente é evaporado e é adicionada água à película resultante. A suspensão é submetida à aplicação de ondas sonoras em um banho de água a 60 °C até que ela se torne clara. Os animais administrados com a formulação auxiliar apresentaram respostas de anticorpo aumentadas a um dado antígeno assim como apresentaram respostas proliferativas de linfócito e linfócito T citotóxico melhoradas. A administração intranasal da composição auxiliar aquosa e um antígeno estimula a produção de IgA secretado de soro e mucosal.
BR9811262-7A 1997-04-01 1998-04-01 Composições auxiliares imunológicas aquosas de lipìdio de monofosforila a. BR9811262A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83107397A 1997-04-01 1997-04-01
PCT/US1998/006528 WO1998043670A2 (en) 1997-04-01 1998-04-01 Aqueous immunologic adjuvant compositions of monophosphoryl lipid a

Publications (1)

Publication Number Publication Date
BR9811262A true BR9811262A (pt) 2000-10-17

Family

ID=25258229

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811262-7A BR9811262A (pt) 1997-04-01 1998-04-01 Composições auxiliares imunológicas aquosas de lipìdio de monofosforila a.

Country Status (19)

Country Link
EP (1) EP0971739B1 (pt)
JP (1) JP5019494B2 (pt)
KR (1) KR100603884B1 (pt)
CN (2) CN1259052A (pt)
AT (1) ATE278419T1 (pt)
AU (1) AU743114B2 (pt)
BR (1) BR9811262A (pt)
CA (1) CA2284586C (pt)
DE (1) DE69826842T2 (pt)
ES (1) ES2227825T3 (pt)
HK (1) HK1026613A1 (pt)
HU (1) HUP0001403A3 (pt)
IL (2) IL132126A0 (pt)
NO (1) NO994760L (pt)
NZ (1) NZ338101A (pt)
PL (1) PL190237B1 (pt)
PT (1) PT971739E (pt)
TR (1) TR199902437T2 (pt)
WO (1) WO1998043670A2 (pt)

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Also Published As

Publication number Publication date
ATE278419T1 (de) 2004-10-15
KR20010005882A (ko) 2001-01-15
PL336698A1 (en) 2000-07-03
CA2284586C (en) 2011-02-08
DE69826842T2 (de) 2005-11-24
KR100603884B1 (ko) 2006-07-24
WO1998043670A3 (en) 1998-12-30
DE69826842D1 (de) 2004-11-11
ES2227825T3 (es) 2005-04-01
CN1326564C (zh) 2007-07-18
HUP0001403A3 (en) 2003-05-28
CN1259052A (zh) 2000-07-05
AU6947398A (en) 1998-10-22
HK1026613A1 (en) 2000-12-22
JP2001526640A (ja) 2001-12-18
AU743114B2 (en) 2002-01-17
EP0971739A2 (en) 2000-01-19
NO994760D0 (no) 1999-09-30
NO994760L (no) 1999-11-26
PT971739E (pt) 2004-12-31
JP5019494B2 (ja) 2012-09-05
NZ338101A (en) 2002-03-28
WO1998043670A2 (en) 1998-10-08
EP0971739B1 (en) 2004-10-06
IL132126A (en) 2006-10-05
TR199902437T2 (xx) 2000-01-21
CA2284586A1 (en) 1998-10-08
HUP0001403A2 (hu) 2000-09-28
PL190237B1 (pl) 2005-11-30
CN1575815A (zh) 2005-02-09
IL132126A0 (en) 2001-03-19

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25A Requested transfer of rights approved

Owner name: CORIXA CORPORATION (US)

Free format text: TRANSFERIDO POR FUSAO DE: RIBI IMMUNOCHEM RESEARCH, INC.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements