BR9810252A - Processo e aparelho para tratar pelo menos tecido biológico parcialmente fixo para impedir a calcificação do tecido após o implante em um corpo mamìfero. - Google Patents

Processo e aparelho para tratar pelo menos tecido biológico parcialmente fixo para impedir a calcificação do tecido após o implante em um corpo mamìfero.

Info

Publication number
BR9810252A
BR9810252A BR9810252-4A BR9810252A BR9810252A BR 9810252 A BR9810252 A BR 9810252A BR 9810252 A BR9810252 A BR 9810252A BR 9810252 A BR9810252 A BR 9810252A
Authority
BR
Brazil
Prior art keywords
tissue
solution
biological tissue
mammalian body
treatment
Prior art date
Application number
BR9810252-4A
Other languages
English (en)
Inventor
Sophie Carpentier
Alain F Carpentier
Lillian J Quintero
Victor S Packham
Jong H Wang
Stefan G Schreck
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of BR9810252A publication Critical patent/BR9810252A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

"PROCESSO E APARELHO PARA TRATAR PELO MENOS TECIDO BIOLóGICO PARCIALMENTE FIXO PARA IMPEDIR A CALCIFICAçãO DO TECIDO APóS O IMPLANTE EM UM CORPO MAMìFERO". Um processo para tratar tecido biológico fixo inibe a calcificação do tecido biológico que resulta da implantação deste em um corpo mamífero. O processo inclui colocar o tecido biológico em contato com uma solução de tratamento, induzindo-se a movimentos relativos do tecido/solução e aquecendo-se a solução. O movimento relativo pode ser induzido agitando-se um recipiente no qual o tecido está imerso na solução de tratamento ou agitando-se a solução dentro do recipiente. O movimento também pode ser induzido fluindo-se a solução de tratamento pelo tecido a ser tratado. O tecido pode estar livre para mover-se no recipiente de tratamento ou pode estar totalmente restringido de movimentos. O fluxo pode ser parte de um sistema de circulação que tenha um reservatório, com um aquecedor sendo fornecido para se aquecer a solução de tratamento no reservatório. Alternativamente, um aparelho de tratamento, que inclua um sistema de circulação de fluido, se desejado, pode ser incluído em uma incubadora. O tecido pode ser montado em uma configuração plana, no geral, paralelo à direção do fluxo de fluido. Uma coluna de fluxo que tenha uma pluralidade de seções divididas por placas perfuradas pode ser usada para tratar diversos tecidos de uma vez.
BR9810252-4A 1997-06-13 1998-05-18 Processo e aparelho para tratar pelo menos tecido biológico parcialmente fixo para impedir a calcificação do tecido após o implante em um corpo mamìfero. BR9810252A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/874,180 US5931969A (en) 1994-07-29 1997-06-13 Methods and apparatuses for treating biological tissue to mitigate calcification
PCT/US1998/010017 WO1998056432A1 (en) 1997-06-13 1998-05-18 Treating biological tissue to mitigate calcification

Publications (1)

Publication Number Publication Date
BR9810252A true BR9810252A (pt) 2000-09-19

Family

ID=25363166

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810252-4A BR9810252A (pt) 1997-06-13 1998-05-18 Processo e aparelho para tratar pelo menos tecido biológico parcialmente fixo para impedir a calcificação do tecido após o implante em um corpo mamìfero.

Country Status (9)

Country Link
US (2) US5931969A (pt)
EP (1) EP0988069B1 (pt)
JP (5) JP3433949B2 (pt)
AT (1) ATE228376T1 (pt)
AU (1) AU7574898A (pt)
BR (1) BR9810252A (pt)
CA (1) CA2293474C (pt)
DE (1) DE69809738T2 (pt)
WO (1) WO1998056432A1 (pt)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5931969A (en) * 1994-07-29 1999-08-03 Baxter International Inc. Methods and apparatuses for treating biological tissue to mitigate calcification
CA2196165C (en) * 1994-07-29 2004-06-08 Sophie Carpentier Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods
US6206917B1 (en) 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
US6630001B2 (en) * 1998-06-24 2003-10-07 International Heart Institute Of Montana Foundation Compliant dehyrated tissue for implantation and process of making the same
US6156531A (en) * 1998-07-20 2000-12-05 Sulzer Carbomedics Inc. Cross-linking tissue with a compound having a C8 to C40 aliphatic chain
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
US6352708B1 (en) 1999-10-14 2002-03-05 The International Heart Institute Of Montana Foundation Solution and method for treating autologous tissue for implant operation
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
US6471723B1 (en) 2000-01-10 2002-10-29 St. Jude Medical, Inc. Biocompatible prosthetic tissue
US20020082688A1 (en) * 2000-09-25 2002-06-27 Tom Sander Technique for shrinking xenograft and allograft heart and vascular tissue
AUPR217300A0 (en) * 2000-12-20 2001-01-25 Ketharanathan, Vettivetpillai Method of creating biological and biosynthetic material for implantation
US6933103B1 (en) * 2001-03-21 2005-08-23 Brennen Medical, Inc. Biocompatible tissue for therapeutic use and method of making same
US20030022146A1 (en) * 2001-07-26 2003-01-30 Cunanan Crystal M. Oxidized bioprosthetic materials
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US6878168B2 (en) * 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US7348175B2 (en) * 2002-03-15 2008-03-25 St3 Development Corporation Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products
BR0305562A (pt) * 2002-07-16 2004-09-28 Edwards Lifesciences Corp Redução acentuada de fosfolipìdio e atenuação da calcificação de materiais biológicos
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
CA2479164A1 (en) * 2002-07-25 2004-02-05 Japan Science And Technology Agency Alternate immersion apparatus and alternate immersion method for treating biological sample
JP4666335B2 (ja) * 2002-09-04 2011-04-06 晶夫 岸田 機械的振動による生物機能の制御方法とその装置
US7189259B2 (en) * 2002-11-26 2007-03-13 Clemson University Tissue material and process for bioprosthesis
US20040153145A1 (en) * 2002-11-26 2004-08-05 Clemson University Fixation method for bioprostheses
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US7410792B2 (en) * 2003-09-19 2008-08-12 St3 Development Corporation Instrumented bioreactor with material property measurement capability and process-based adjustment for conditioning tissue engineered medical products
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
CA2548534C (en) 2003-10-28 2014-01-07 Allosource Methods for determining microbial contamination of allograft products
US7989157B2 (en) * 2005-01-11 2011-08-02 Medtronic, Inc. Solution for storing bioprosthetic tissue used in a biological prosthesis
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
EP1895942B1 (en) 2005-05-27 2020-05-13 Medtronic, Inc. Gasket with collar for prosthetic heart valves
US7670762B2 (en) * 2006-01-17 2010-03-02 Brennen Medical, Llc Biocompatible tissue graft material for implant and method of making
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
EP2023860A2 (en) 2006-04-29 2009-02-18 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
US9006510B2 (en) * 2006-06-29 2015-04-14 Mayo Foundation For Medical Education And Research Genetically modified heart valve xenografts
CN101626682B (zh) 2006-10-27 2014-04-16 爱德华兹生命科学公司 用于外科植入的生物组织
US8142805B1 (en) 2006-11-06 2012-03-27 Clemson University Research Foundation Implantable devices including fixed tissues
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US9410113B2 (en) * 2007-10-26 2016-08-09 St3 Development Corporation Bioreactor system for three-dimensional tissue stimulator
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
ES2903231T3 (es) 2008-02-26 2022-03-31 Jenavalve Tech Inc Stent para el posicionamiento y anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
CA2737461A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US20110152770A1 (en) 2009-07-30 2011-06-23 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
US10126216B2 (en) * 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
WO2011119754A2 (en) 2010-03-23 2011-09-29 Edwards Lifesciences Corporation Methods of conditioning sheet bioprosthetic tissue
WO2011139488A2 (en) 2010-05-06 2011-11-10 Mayo Foundation For Medical Education And Research Methods and materials for reducing cardiac xenograft rejection
US20110287403A1 (en) * 2010-05-21 2011-11-24 Ciccone Ii William Graft Tensioning Device
BR112012029896A2 (pt) 2010-05-25 2017-06-20 Jenavalve Tech Inc válcula cardíaca protética para endoprótese e endoprótese
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US9095430B2 (en) 2010-08-24 2015-08-04 Southern Lights Ventures (2002) Limited Biomaterials with enhanced properties and devices made therefrom
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
CA3027755C (en) 2010-12-14 2021-05-11 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US9358107B2 (en) 2011-06-30 2016-06-07 Edwards Lifesciences Corporation Systems, dies, and methods for processing pericardial tissue
CN102423505B (zh) * 2011-10-27 2014-12-10 上海微创医疗器械（集团）有限公司 膜式渗透汽化式固定人工生物瓣的方法及装置
US9606035B2 (en) 2011-12-21 2017-03-28 Ta Instruments-Waters Llc System for mechanical stimulation and characterization of biologic samples
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CN105491978A (zh) 2013-08-30 2016-04-13 耶拿阀门科技股份有限公司 用于假体瓣膜的径向可折叠框架及其制造方法
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) * 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
DE102013223384B4 (de) * 2013-11-15 2015-05-28 Leica Biosystems Nussloch Gmbh Fixierung von Gewebeproben unter Verwendung Aldehyde freisetzender stickstoffhaltiger Verbindungen
EP3288495B1 (en) 2015-05-01 2019-09-25 JenaValve Technology, Inc. Device with reduced pacemaker rate in heart valve replacement
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
WO2018138658A1 (en) 2017-01-27 2018-08-02 Jenavalve Technology, Inc. Heart valve mimicry
EP3366324A1 (en) 2017-02-22 2018-08-29 Epygon Product and method for the treatment of bioprosthetic tissues
WO2018222434A1 (en) 2017-05-31 2018-12-06 Edwards Lifesciences Corporation Collagen fibers and articles formed therefrom
US11395726B2 (en) 2017-09-11 2022-07-26 Incubar Llc Conduit vascular implant sealing device for reducing endoleaks
CR20200194A (es) 2018-01-23 2020-11-04 Edwards Lifesciences Corp Método para el estiramiento previo de materiales biocompatibles implantables y materiales y dispositivos producidos a medida
CN113164258A (zh) 2018-11-01 2021-07-23 爱德华兹生命科学公司 经导管再生肺动脉瓣
US11648109B2 (en) 2019-02-04 2023-05-16 Medtronic, Inc. Balloon expandable frame for transcatheter implantation of a cardiac valve prosthesis
WO2020236520A1 (en) 2019-05-17 2020-11-26 Medtronic, Inc. Supra annular tapered balloon expandable stent for transcatheter implantation of a cardiac valve prosthesis
US12011349B2 (en) 2020-03-04 2024-06-18 Medtronic, Inc. Balloon expandable stent with lengthened commissure posts for transcatheter implantation of a cardiac valve prosthesis
DE102021112930A1 (de) 2021-05-19 2022-11-24 Hochschule Wismar Vorrichtung und Verfahren zum Dezellularisieren und/oder Reinigen von Gewebe Beschreibung

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2393580A (en) * 1942-03-31 1946-01-22 Edwin C Weiskopf Method of preparing tissue
US3002895A (en) * 1957-02-11 1961-10-03 Freedman David Incubator-shaker apparatus
US3093439A (en) * 1961-07-05 1963-06-11 Johnson & Johnson Process for preparing tanned collagenous material with dialdehyde starch
US3961097A (en) * 1971-10-28 1976-06-01 Gravlee Jr Joseph F Method of preparing tissue for microscopic examination
US3937422A (en) * 1972-12-01 1976-02-10 Sansui Electric Co., Ltd. Magnetic tape recording and reproducing machines
US3870789A (en) * 1972-12-01 1975-03-11 Kurt W Mikat Enhancement of morphologic detail in tissue
US3927422A (en) 1973-12-12 1975-12-23 Philip Nicholas Sawyer Prosthesis and method for making same
US3966401A (en) * 1974-07-01 1976-06-29 Hancock Laboratories Incorporated Preparing natural tissue for implantation so as to provide improved flexibility
US4050893A (en) * 1974-07-22 1977-09-27 Hancock Laboratories, Inc. Arrangement for preparing natural tissue for implantation
IL47062A (en) * 1975-04-10 1979-07-25 Yeda Res & Dev Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde
US4082507A (en) * 1976-05-10 1978-04-04 Sawyer Philip Nicholas Prosthesis and method for making the same
US4323358A (en) * 1981-04-30 1982-04-06 Vascor, Inc. Method for inhibiting mineralization of natural tissue during implantation
US4372743A (en) * 1981-06-22 1983-02-08 American Hospital Supply Corp. Low-pressure fixation of valvular tissue intended for implantation
US4350492A (en) * 1981-08-24 1982-09-21 Vascor, Inc. Method for preparing tissue heart valve
FR2523810B1 (fr) * 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
US4402697A (en) * 1982-08-25 1983-09-06 Extracorporeal Medical Specialties, Inc. Method for inhibiting mineralization of natural tissue during implantation
US4405327A (en) * 1982-08-25 1983-09-20 Extracorporeal Medical Specialties, Inc. Method for inhibiting mineralization of natural tissue during implantation
WO1984001894A1 (en) * 1982-11-12 1984-05-24 American Hospital Supply Corp Chemical sterilization of implantable biological tissue
IT1159433B (it) * 1983-07-25 1987-02-25 Sorin Biomedica Spa Procedimento ed apparecchiatura per la fabbricazione di lembi valvolari per protesi valvolari cardiache e protesi valvolare cardiaca provvista di tali lembi
US4770665A (en) * 1985-11-05 1988-09-13 American Hospital Supply Corporation Elastomeric polymer incorporation into implantable biological tissue to inhibit calcification
US4911713A (en) * 1986-03-26 1990-03-27 Sauvage Lester R Method of making vascular prosthesis by perfusion
US4786287A (en) * 1986-10-10 1988-11-22 Baxter Travenol Laboratories Process for decreasing residual aldehyde levels in implantable bioprosthetic tissue
US4800603A (en) * 1987-01-30 1989-01-31 Jaffe Norman R Tissue fixation with vapor
US4990131A (en) * 1987-09-01 1991-02-05 Herbert Dardik Tubular prostheses for vascular reconstructive surgery and process for preparing same
US5131908A (en) * 1987-09-01 1992-07-21 Herbert Dardik Tubular prosthesis for vascular reconstructive surgery and process for preparing same
US5746775A (en) * 1988-04-01 1998-05-05 The Board Of Regent6S Of The University Of Michigan Method of making calcification-resistant bioprosthetic tissue
DE3834545A1 (de) * 1988-10-11 1990-04-12 Rau Guenter Flexibles schliessorgan, insbesondere herzklappe, und verfahren zur herstellung desselben
US5002566A (en) * 1989-02-17 1991-03-26 Baxter International Inc. Calcification mitigation of bioprosthetic implants
AU626686B2 (en) * 1989-06-09 1992-08-06 Medtronic, Inc. Dynamic fixation of porcine aortic valves
US5068086A (en) * 1990-06-12 1991-11-26 Raytheon Company Method and apparatus for batch fixating tissue specimens
US5104405A (en) * 1991-02-21 1992-04-14 The University Of Southern California Process for improving the biostability of tissue implant devices and bioprosthetic implants so produced
US5275954A (en) * 1991-03-05 1994-01-04 Lifenet Process for demineralization of bone using column extraction
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
US5447536A (en) * 1994-02-17 1995-09-05 Biomedical Design, Inc. Method for fixation of biological tissue
WO1995024873A1 (en) * 1994-03-14 1995-09-21 Cryolife, Inc. Treated tissue for implantation and preparation methods
US5595571A (en) * 1994-04-18 1997-01-21 Hancock Jaffe Laboratories Biological material pre-fixation treatment
JPH09502379A (ja) * 1994-06-15 1997-03-11 セント ジュード メディカル インコーポレイテッド 天然組織の改良された架橋
US5931969A (en) * 1994-07-29 1999-08-03 Baxter International Inc. Methods and apparatuses for treating biological tissue to mitigate calcification
CA2196165C (en) * 1994-07-29 2004-06-08 Sophie Carpentier Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods
US5674298A (en) * 1994-10-21 1997-10-07 The Board Of Regents Of The University Of Michigan Calcification-resistant bioprosthetic tissue and methods of making same
KR0129833B1 (ko) * 1994-11-09 1998-04-04 박성수 조직 배양 방법 및 장치
AU698527B2 (en) * 1994-12-29 1998-10-29 Allergan, Inc. Acetylenes disubstituted with a 5 or 8 substituted tetrahydronaphthyl or dihydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5792603A (en) * 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts

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WO1998056432A1 (en) 1998-12-17
CA2293474A1 (en) 1998-12-17
US5931969A (en) 1999-08-03
ATE228376T1 (de) 2002-12-15
JP2004136098A (ja) 2004-05-13
AU7574898A (en) 1998-12-30
JP2006043468A (ja) 2006-02-16
US6210957B1 (en) 2001-04-03
EP0988069B1 (en) 2002-11-27
JP5300154B2 (ja) 2013-09-25
DE69809738D1 (de) 2003-01-09
DE69809738T2 (de) 2003-08-21
CA2293474C (en) 2003-07-29
JP3433949B2 (ja) 2003-08-04
JP3764084B2 (ja) 2006-04-05
EP0988069A1 (en) 2000-03-29
JP2002179501A (ja) 2002-06-26
JP2011031054A (ja) 2011-02-17

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