BR9807598A - Production process for intravenous immune serum globulin and resulting product - Google Patents

Production process for intravenous immune serum globulin and resulting product

Info

Publication number
BR9807598A
BR9807598A BR9807598-5A BR9807598A BR9807598A BR 9807598 A BR9807598 A BR 9807598A BR 9807598 A BR9807598 A BR 9807598A BR 9807598 A BR9807598 A BR 9807598A
Authority
BR
Brazil
Prior art keywords
globulin
resulting product
production process
immune serum
serum globulin
Prior art date
Application number
BR9807598-5A
Other languages
Portuguese (pt)
Inventor
Raja R Mamidi
Andranik Bagdasarian
Kazuo Takechi
Gorgonio Canaveral
Original Assignee
Alpha Therapeutic Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Therapeutic Corp filed Critical Alpha Therapeutic Corp
Publication of BR9807598A publication Critical patent/BR9807598A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO DE PRODUçãO PARA GLOBULINA DE SORO IMUNOLóGICO INTRAVENOSO E PRODUTO RESULTANTE"<D>. Processo para a produção de uma solução de gama-globulina que pode ser administrada intravenosamente substancialmente isenta de vírus contaminantes por tratamento com calor para inativação viral e fracionamento de uma solução de gama-globulina impura e então tratando a gama-globulina purificada com um solvente-detergente para inativação viral adicional.Invention Patent: <B> "PRODUCTION PROCESS FOR INTRAVENOUS IMMUNOLOGICAL SERUM GLOBULIN AND RESULTING PRODUCT" <D>. Process for the production of a gamma-globulin solution that can be administered intravenously substantially free of contaminating viruses by heat treatment for viral inactivation and fractionation of an impure gamma-globulin solution and then treating the purified gamma-globulin with a solvent- detergent for additional viral inactivation.

BR9807598-5A 1997-12-24 1998-12-07 Production process for intravenous immune serum globulin and resulting product BR9807598A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99795297A 1997-12-24 1997-12-24
PCT/US1998/025208 WO1999033484A1 (en) 1997-12-24 1998-12-07 Production process for intravenous immune serum globulin and resultant product

Publications (1)

Publication Number Publication Date
BR9807598A true BR9807598A (en) 2000-02-22

Family

ID=25544595

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807598-5A BR9807598A (en) 1997-12-24 1998-12-07 Production process for intravenous immune serum globulin and resulting product

Country Status (15)

Country Link
EP (1) EP0971727A4 (en)
JP (1) JP2001514672A (en)
KR (1) KR20000075562A (en)
CN (1) CN1214042C (en)
AR (1) AR018260A1 (en)
AU (1) AU747893B2 (en)
BR (1) BR9807598A (en)
CA (1) CA2281938A1 (en)
CO (1) CO4970799A1 (en)
IL (1) IL131471A0 (en)
MY (1) MY117328A (en)
RU (1) RU2198668C2 (en)
TW (1) TW546144B (en)
UA (1) UA64742C2 (en)
WO (1) WO1999033484A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2270044T3 (en) 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
IL146433A0 (en) * 1999-06-15 2002-07-25 Alpha Therapeutic Corp A process for the preparation of an intravenously-administerable gamma globulin solution
JP2004525077A (en) * 2000-09-28 2004-08-19 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド Treatment of immune-mediated diseases by oral administration of immunoglobulin G enriched plasma fraction
ES2184594B1 (en) * 2001-01-17 2004-01-01 Probitas Pharma Sa PROCEDURE FOR THE PRODUCTION OF GAMMAGLOBULINA G HUMANA INACTIVADA OF VIRUS.
US6893639B2 (en) * 2001-10-19 2005-05-17 Hemacare Corporation Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
JP5525118B2 (en) 2002-09-11 2014-06-18 中外製薬株式会社 Protein purification method
TWI391399B (en) 2005-05-25 2013-04-01 Hoffmann La Roche Method for determining the concentration of a salt for eluting a polypeptide
KR100791502B1 (en) * 2006-09-29 2008-01-03 한스바이오메드 주식회사 Production methods of virus inactivated and cell-free body implant
US8980610B2 (en) * 2008-11-20 2015-03-17 Biogen Idec Ma Inc. Arginine inactivation of viruses
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
ES2381828B1 (en) * 2012-03-20 2012-11-16 Grifols, S.A. PROCEDURE TO OBTAIN A COMPOSITION OF IgG THROUGH THERMAL TREATMENT
CA2941230C (en) 2014-03-11 2020-08-25 Green Cross Holdings Corporation Method for purifying immunoglobulin
CN107880116B (en) * 2016-09-30 2023-02-03 盖立复集团公司 Method for producing immunoglobulins

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604759C2 (en) * 1976-02-07 1983-06-01 SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld Method of Obtaining IV Compatible Gamma Globulins
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4835257A (en) * 1984-07-07 1989-05-30 Armour Pharma Gmbh Process for preparing gamma globulin suitable for intravenous administration using peg and a citrate buffer
FR2582515B1 (en) * 1985-05-30 1988-11-04 Merieux Inst PROCESS FOR THE PREPARATION OF GAMMA-GOBULINS ADMINISTRABLE BY THE INTRAVENOUS ROUTE AND GAMMA-GLOBULINS OBTAINED
JPH0662436B2 (en) * 1986-05-19 1994-08-17 株式会社ミドリ十字 Method for producing intravenous immunoglobulin preparation
US4841023A (en) * 1986-06-25 1989-06-20 New York Blood Center, Inc. Inactivation of viruses in labile protein-containing compositions using fatty acids
DE3825429C2 (en) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Method for producing an intravenously administrable polyclonal immunoglobulin preparation with a high IgM content
CA2007545A1 (en) * 1989-01-13 1990-07-13 Yahiro Uemura Production method for protein-containing composition
JP2965069B2 (en) * 1989-01-13 1999-10-18 吉富製薬株式会社 Method for producing protein-containing composition
EP0431129B1 (en) * 1989-06-15 1996-05-29 Rorer International (Overseas) Inc. Methods for the inactivation of viruses in viral-contaminated pharmaceutical compositions
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
JP3145696B2 (en) * 1990-10-05 2001-03-12 日本ケミカルリサーチ株式会社 Method for producing secretory immunoglobulin A preparation
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
DE4431833C1 (en) * 1994-09-07 1995-05-18 Blutspendedienst Der Drk Lande Prepn. of an anti-haemophilic factor from a cryo-precipitate
JP4003235B2 (en) * 1994-09-30 2007-11-07 三菱ウェルファーマ株式会社 Method for producing intravenous immunoglobulin preparation

Also Published As

Publication number Publication date
CA2281938A1 (en) 1999-07-08
MY117328A (en) 2004-06-30
AU747893B2 (en) 2002-05-30
AU1703899A (en) 1999-07-19
JP2001514672A (en) 2001-09-11
KR20000075562A (en) 2000-12-15
AR018260A1 (en) 2001-11-14
TW546144B (en) 2003-08-11
CO4970799A1 (en) 2000-11-07
WO1999033484A1 (en) 1999-07-08
EP0971727A4 (en) 2005-01-19
EP0971727A1 (en) 2000-01-19
CN1214042C (en) 2005-08-10
CN1252729A (en) 2000-05-10
IL131471A0 (en) 2001-01-28
UA64742C2 (en) 2004-03-15
RU2198668C2 (en) 2003-02-20

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Legal Events

Date Code Title Description
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART 36 DA LPI (LEI 9.279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.