CO4970799A1 - PRODUCTION PROCESS FOR IMMUNOGLOBULIN SERICA INTRAVENO- SA AND RESULTING PRODUCT - Google Patents

PRODUCTION PROCESS FOR IMMUNOGLOBULIN SERICA INTRAVENO- SA AND RESULTING PRODUCT

Info

Publication number
CO4970799A1
CO4970799A1 CO98076460A CO98076460A CO4970799A1 CO 4970799 A1 CO4970799 A1 CO 4970799A1 CO 98076460 A CO98076460 A CO 98076460A CO 98076460 A CO98076460 A CO 98076460A CO 4970799 A1 CO4970799 A1 CO 4970799A1
Authority
CO
Colombia
Prior art keywords
gamma globulin
globulin solution
intraveno
serica
immunoglobulin
Prior art date
Application number
CO98076460A
Other languages
Spanish (es)
Inventor
R Maidi Raja
Bagdasarian Andranik
Canaveral Gorgonio
Takechi Kazuo
Original Assignee
Alpha Therapeutic Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Therapeutic Corp filed Critical Alpha Therapeutic Corp
Publication of CO4970799A1 publication Critical patent/CO4970799A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Un proceso para preparar una solución de gammaglobulina quepuede ser administrada por vía intravenosa, que comprende:(a) tratar con calor una solución de gammaglobulina impura bajo unas condiciones de tiempo y temperatura suficientes para inactivar los virus sensibles al calor;(b) someter a la solución de gammaglobulina tratada con calor a un fraccionamiento con polietilenglicol para obtener una solución de gammaglobulina purificada; y (c) tratar la solución de gammaglobulina purificada con un solvente orgánico para inactivar los virus con cubierta.A process for preparing an intravenous gamma globulin solution, comprising: (a) heat treating an impure gamma globulin solution under conditions of time and temperature sufficient to inactivate heat sensitive viruses; (b) subjecting the heat-treated gamma globulin solution to a fractionation with polyethylene glycol to obtain a purified gamma globulin solution; and (c) treating the purified gamma globulin solution with an organic solvent to inactivate the coated viruses.

CO98076460A 1997-12-24 1998-12-23 PRODUCTION PROCESS FOR IMMUNOGLOBULIN SERICA INTRAVENO- SA AND RESULTING PRODUCT CO4970799A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99795297A 1997-12-24 1997-12-24

Publications (1)

Publication Number Publication Date
CO4970799A1 true CO4970799A1 (en) 2000-11-07

Family

ID=25544595

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98076460A CO4970799A1 (en) 1997-12-24 1998-12-23 PRODUCTION PROCESS FOR IMMUNOGLOBULIN SERICA INTRAVENO- SA AND RESULTING PRODUCT

Country Status (15)

Country Link
EP (1) EP0971727A4 (en)
JP (1) JP2001514672A (en)
KR (1) KR20000075562A (en)
CN (1) CN1214042C (en)
AR (1) AR018260A1 (en)
AU (1) AU747893B2 (en)
BR (1) BR9807598A (en)
CA (1) CA2281938A1 (en)
CO (1) CO4970799A1 (en)
IL (1) IL131471A0 (en)
MY (1) MY117328A (en)
RU (1) RU2198668C2 (en)
TW (1) TW546144B (en)
UA (1) UA64742C2 (en)
WO (1) WO1999033484A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2527915T3 (en) 1998-06-09 2015-02-02 Csl Behring Ag Liquid immunoglobulin G (IgG) product
EP1185290A4 (en) * 1999-06-15 2005-08-31 Alpha Therapeutic Corp Manufacturing method for intravenous immune globulin and resultant product
JP2004525077A (en) * 2000-09-28 2004-08-19 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド Treatment of immune-mediated diseases by oral administration of immunoglobulin G enriched plasma fraction
ES2184594B1 (en) * 2001-01-17 2004-01-01 Probitas Pharma Sa PROCEDURE FOR THE PRODUCTION OF GAMMAGLOBULINA G HUMANA INACTIVADA OF VIRUS.
US6893639B2 (en) 2001-10-19 2005-05-17 Hemacare Corporation Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
ES2558303T3 (en) 2002-09-11 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Protein Purification Method
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
KR100791502B1 (en) * 2006-09-29 2008-01-03 한스바이오메드 주식회사 Production methods of virus inactivated and cell-free body implant
EP2350271B1 (en) * 2008-11-20 2016-01-27 Biogen MA Inc. Arginine inactivation of enveloped viruses
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
ES2381828B1 (en) * 2012-03-20 2012-11-16 Grifols, S.A. PROCEDURE TO OBTAIN A COMPOSITION OF IgG THROUGH THERMAL TREATMENT
ES2785375T3 (en) 2014-03-11 2020-10-06 Green Cross Holdings Corp Immunoglobulin purification procedure
CN107880116B (en) * 2016-09-30 2023-02-03 盖立复集团公司 Method for producing immunoglobulins

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604759C2 (en) * 1976-02-07 1983-06-01 SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld Method of Obtaining IV Compatible Gamma Globulins
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4835257A (en) * 1984-07-07 1989-05-30 Armour Pharma Gmbh Process for preparing gamma globulin suitable for intravenous administration using peg and a citrate buffer
FR2582515B1 (en) * 1985-05-30 1988-11-04 Merieux Inst PROCESS FOR THE PREPARATION OF GAMMA-GOBULINS ADMINISTRABLE BY THE INTRAVENOUS ROUTE AND GAMMA-GLOBULINS OBTAINED
JPH0662436B2 (en) * 1986-05-19 1994-08-17 株式会社ミドリ十字 Method for producing intravenous immunoglobulin preparation
US4841023A (en) * 1986-06-25 1989-06-20 New York Blood Center, Inc. Inactivation of viruses in labile protein-containing compositions using fatty acids
DE3825429C2 (en) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Method for producing an intravenously administrable polyclonal immunoglobulin preparation with a high IgM content
JP2965069B2 (en) * 1989-01-13 1999-10-18 吉富製薬株式会社 Method for producing protein-containing composition
EP0378208B2 (en) * 1989-01-13 2003-01-15 Mitsubishi Pharma Corporation Production method for protein-containing composition
CA2034489C (en) * 1989-06-15 1996-07-16 Michael E. Hrinda Methods for the inactivation of viruses in viral-contaminated pharmaceutical compositions
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
JP3145696B2 (en) * 1990-10-05 2001-03-12 日本ケミカルリサーチ株式会社 Method for producing secretory immunoglobulin A preparation
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
DE4431833C1 (en) * 1994-09-07 1995-05-18 Blutspendedienst Der Drk Lande Prepn. of an anti-haemophilic factor from a cryo-precipitate
JP4003235B2 (en) * 1994-09-30 2007-11-07 三菱ウェルファーマ株式会社 Method for producing intravenous immunoglobulin preparation

Also Published As

Publication number Publication date
WO1999033484A1 (en) 1999-07-08
CN1252729A (en) 2000-05-10
KR20000075562A (en) 2000-12-15
EP0971727A1 (en) 2000-01-19
IL131471A0 (en) 2001-01-28
MY117328A (en) 2004-06-30
TW546144B (en) 2003-08-11
CA2281938A1 (en) 1999-07-08
JP2001514672A (en) 2001-09-11
AU1703899A (en) 1999-07-19
UA64742C2 (en) 2004-03-15
RU2198668C2 (en) 2003-02-20
AR018260A1 (en) 2001-11-14
AU747893B2 (en) 2002-05-30
BR9807598A (en) 2000-02-22
CN1214042C (en) 2005-08-10
EP0971727A4 (en) 2005-01-19

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