BR0011648A - Manufacturing method of intravenous immunoglobulin and resulting product - Google Patents

Manufacturing method of intravenous immunoglobulin and resulting product

Info

Publication number
BR0011648A
BR0011648A BR0011648-3A BR0011648A BR0011648A BR 0011648 A BR0011648 A BR 0011648A BR 0011648 A BR0011648 A BR 0011648A BR 0011648 A BR0011648 A BR 0011648A
Authority
BR
Brazil
Prior art keywords
globulin
gamma
resulting product
manufacturing
intravenous immunoglobulin
Prior art date
Application number
BR0011648-3A
Other languages
Portuguese (pt)
Inventor
Raja R Mamidi
Andranik Bagdasarian
Gorgonio Canaveral
Original Assignee
Alpha Therapeutic Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Therapeutic Corp filed Critical Alpha Therapeutic Corp
Publication of BR0011648A publication Critical patent/BR0011648A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Patente de Invenção: "MéTODO DE FABRICAçãO DE IMUNOGLOBULINA INTRAVENOSA E PRODUTO RESULTANTE". Um processo contínuo para a produção de solução de gama globulina intravenosamente administrável substancialmente sem vírus contaminantes através de tratamento com calor de uma solução de gama globulina para inativação viral, fracionamento para se obter uma solução de gama globulina purificada sem precipitação da gama globulina desejada e então tratamento da gama globulina purificada com um solvente-detergente para inativação viral adicional. Os sólidos de gama globulina parcialmente purificados não são recuperados com um produto intermediário durante o processo descrito.Invention Patent: "METHOD OF MANUFACTURING INTRAVENOUS IMMUNOGLOBULIN AND RESULTING PRODUCT". A continuous process for the production of intravenously administrable gamma globulin solution substantially free of contaminating viruses through heat treatment of a gamma globulin solution for viral inactivation, fractionation to obtain a purified gamma globulin solution without precipitation of the desired globulin gamma and then treatment of the purified globulin range with a detergent-solvent for additional viral inactivation. The partially purified gamma globulin solids are not recovered with an intermediate product during the described process.

BR0011648-3A 1999-06-15 2000-06-06 Manufacturing method of intravenous immunoglobulin and resulting product BR0011648A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33328999A 1999-06-15 1999-06-15
PCT/US2000/011870 WO2000076534A1 (en) 1999-06-15 2000-06-06 Manufacturing method for intravenous immune globulin and resultant product

Publications (1)

Publication Number Publication Date
BR0011648A true BR0011648A (en) 2002-03-19

Family

ID=23302162

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011648-3A BR0011648A (en) 1999-06-15 2000-06-06 Manufacturing method of intravenous immunoglobulin and resulting product

Country Status (13)

Country Link
EP (1) EP1185290A4 (en)
JP (1) JP2003501480A (en)
KR (1) KR20020010921A (en)
CN (1) CN1358100A (en)
AU (1) AU756071B2 (en)
BR (1) BR0011648A (en)
CA (1) CA2375560A1 (en)
CZ (1) CZ20014456A3 (en)
HK (1) HK1048252A1 (en)
IL (1) IL146433A0 (en)
PL (1) PL352910A1 (en)
WO (1) WO2000076534A1 (en)
ZA (1) ZA200110168B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2437518A (en) * 2006-04-26 2007-10-31 Noel Kavanagh Antiserum preparation
WO2007136327A1 (en) * 2006-05-22 2007-11-29 Ge Healthcare Bio-Sciences Ab A method of producing igg
US7932356B1 (en) * 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
ES2785375T3 (en) * 2014-03-11 2020-10-06 Green Cross Holdings Corp Immunoglobulin purification procedure
EP3118210B1 (en) * 2014-03-11 2019-11-13 Green Cross Holdings Corporation Method for purifying immunoglobulin
KR101941974B1 (en) * 2016-11-18 2019-01-24 주식회사 녹십자 Methods for Eliminating Factor XI during Plasma Protein Purification

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
FR2582515B1 (en) * 1985-05-30 1988-11-04 Merieux Inst PROCESS FOR THE PREPARATION OF GAMMA-GOBULINS ADMINISTRABLE BY THE INTRAVENOUS ROUTE AND GAMMA-GLOBULINS OBTAINED
JPH0662436B2 (en) * 1986-05-19 1994-08-17 株式会社ミドリ十字 Method for producing intravenous immunoglobulin preparation
US4841023A (en) * 1986-06-25 1989-06-20 New York Blood Center, Inc. Inactivation of viruses in labile protein-containing compositions using fatty acids
EP0378208B2 (en) * 1989-01-13 2003-01-15 Mitsubishi Pharma Corporation Production method for protein-containing composition
DE3927111C3 (en) * 1989-08-17 1994-09-01 Biotest Pharma Gmbh Process for the preparation of unmodified intravenous IgM and / or IgA-containing immunoglobulin preparations
JP3145696B2 (en) * 1990-10-05 2001-03-12 日本ケミカルリサーチ株式会社 Method for producing secretory immunoglobulin A preparation
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
DE4431833C1 (en) * 1994-09-07 1995-05-18 Blutspendedienst Der Drk Lande Prepn. of an anti-haemophilic factor from a cryo-precipitate
UA64742C2 (en) * 1997-12-24 2004-03-15 Альфа Терапевтик Корпорейшн Process for producing intravenously-administrable gamma globulin solution and product manufactured by this process

Also Published As

Publication number Publication date
AU756071B2 (en) 2003-01-02
CZ20014456A3 (en) 2002-05-15
AU5722400A (en) 2001-01-02
CN1358100A (en) 2002-07-10
ZA200110168B (en) 2002-08-26
HK1048252A1 (en) 2003-03-28
WO2000076534A1 (en) 2000-12-21
EP1185290A1 (en) 2002-03-13
KR20020010921A (en) 2002-02-06
CA2375560A1 (en) 2000-12-21
IL146433A0 (en) 2002-07-25
EP1185290A4 (en) 2005-08-31
PL352910A1 (en) 2003-09-22
JP2003501480A (en) 2003-01-14

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 10 (VIII), 11 E 13 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.