BR9807106A - Processo para a preparação de haletos de zinco-heteroarila - Google Patents
Processo para a preparação de haletos de zinco-heteroarilaInfo
- Publication number
- BR9807106A BR9807106A BR9807106-8A BR9807106A BR9807106A BR 9807106 A BR9807106 A BR 9807106A BR 9807106 A BR9807106 A BR 9807106A BR 9807106 A BR9807106 A BR 9807106A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- zinc
- het
- formula
- compounds
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000011701 zinc Substances 0.000 abstract 2
- 229910052725 zinc Inorganic materials 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 238000006263 metalation reaction Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/06—Zinc compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
<B> PROCESSO PARA A PREPARAçãO DE HALETOS DE ZINCO-HETEROARILA <D> é descrito um processo para a preparação de haletos de zinco-heteroarila da fórmula (II): Het-Zn-X, em que Het é um grupo hetecocíclico aromático de 5 ou 6 membros opcionalmente substituído com um ou dois heteroátomos selecionados dentre nitrogênio, oxigênio ou enxofre; X é um átomo de cloro, bromo ou iodo; compreendendo reação de metalação de haleto de heteroarila com zinco metálico opcionalmente ativado por lavagem com ácidos. Os compostos da fórmula (II) são intermediários úteis na síntese para a preparação de compostos dotados de atividade farmacológica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000081A IT1289910B1 (it) | 1997-01-17 | 1997-01-17 | Processo per la preparazione di eteroaril-zinco alogenuri |
| PCT/EP1998/000126 WO1998031687A1 (en) | 1997-01-17 | 1998-01-12 | Process for the preparation of heteroaryl-zinc halides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9807106A true BR9807106A (pt) | 2000-05-16 |
Family
ID=11375647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9807106-8A BR9807106A (pt) | 1997-01-17 | 1998-01-12 | Processo para a preparação de haletos de zinco-heteroarila |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6211380B1 (pt) |
| EP (1) | EP0970091B1 (pt) |
| JP (1) | JP4044966B2 (pt) |
| AT (1) | ATE240961T1 (pt) |
| BR (1) | BR9807106A (pt) |
| CA (1) | CA2276176A1 (pt) |
| CZ (1) | CZ295206B6 (pt) |
| DE (1) | DE69814837T9 (pt) |
| ES (1) | ES2198694T3 (pt) |
| IL (1) | IL130470A (pt) |
| IT (1) | IT1289910B1 (pt) |
| WO (1) | WO1998031687A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2826963B1 (fr) * | 2001-07-04 | 2006-01-27 | Rhodia Chimie Sa | Preparation d'organozinciques aromatiques et composition pour ce faire |
| JP4907486B2 (ja) * | 2001-12-04 | 2012-03-28 | 田辺三菱製薬株式会社 | グリニャール試薬の製法 |
| TW200300676A (en) * | 2001-12-04 | 2003-06-16 | Tanabe Seiyaku Co | Biotin intermediate and its production |
| CN1834095B (zh) | 2005-03-18 | 2011-04-20 | 中国科学院上海药物研究所 | 一类非核苷类抗病毒抑制剂及其制备方法和用途 |
| DE102006015378A1 (de) * | 2006-04-03 | 2007-10-04 | Ludwig-Maximilians-Universität München | Verfahren zur Synthese von Organoelementverbindungen |
| WO2016129818A1 (ko) * | 2015-02-10 | 2016-08-18 | 아주대학교산학협력단 | 폴리올레핀-폴리스티렌 블록공중합체를 포함하는 유기 아연 화합물 및 이의 제조 방법 |
| KR101657925B1 (ko) | 2015-02-10 | 2016-09-20 | 아주대학교산학협력단 | 폴리올레핀-폴리스티렌 블록공중합체를 포함하는 유기 아연 화합물 및 이의 제조 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015086A1 (en) * | 1992-02-04 | 1993-08-05 | Board Of Regents Of The University Of Nebraska | Highly reactive forms of zinc and reagents thereof |
-
1997
- 1997-01-17 IT IT97MI000081A patent/IT1289910B1/it not_active IP Right Cessation
-
1998
- 1998-01-12 US US09/341,297 patent/US6211380B1/en not_active Expired - Fee Related
- 1998-01-12 JP JP53363698A patent/JP4044966B2/ja not_active Expired - Fee Related
- 1998-01-12 BR BR9807106-8A patent/BR9807106A/pt not_active IP Right Cessation
- 1998-01-12 ES ES98904054T patent/ES2198694T3/es not_active Expired - Lifetime
- 1998-01-12 IL IL13047098A patent/IL130470A/en not_active IP Right Cessation
- 1998-01-12 CA CA002276176A patent/CA2276176A1/en not_active Abandoned
- 1998-01-12 WO PCT/EP1998/000126 patent/WO1998031687A1/en active IP Right Grant
- 1998-01-12 CZ CZ19992545A patent/CZ295206B6/cs not_active IP Right Cessation
- 1998-01-12 EP EP98904054A patent/EP0970091B1/en not_active Expired - Lifetime
- 1998-01-12 DE DE69814837T patent/DE69814837T9/de not_active Expired - Fee Related
- 1998-01-12 AT AT98904054T patent/ATE240961T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69814837D1 (de) | 2003-06-26 |
| US6211380B1 (en) | 2001-04-03 |
| ITMI970081A1 (it) | 1998-07-17 |
| IT1289910B1 (it) | 1998-10-19 |
| JP4044966B2 (ja) | 2008-02-06 |
| EP0970091A1 (en) | 2000-01-12 |
| CZ254599A3 (cs) | 2000-01-12 |
| WO1998031687A1 (en) | 1998-07-23 |
| CZ295206B6 (cs) | 2005-06-15 |
| JP2001508787A (ja) | 2001-07-03 |
| IL130470A (en) | 2004-01-04 |
| DE69814837T9 (de) | 2004-09-09 |
| ATE240961T1 (de) | 2003-06-15 |
| ES2198694T3 (es) | 2004-02-01 |
| IL130470A0 (en) | 2000-06-01 |
| EP0970091B1 (en) | 2003-05-21 |
| CA2276176A1 (en) | 1998-07-23 |
| DE69814837T2 (de) | 2004-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1914 DE 11/09/2007. |