BR9804629A - Processo contìnuo para diazometano - Google Patents

Processo contìnuo para diazometano

Info

Publication number
BR9804629A
BR9804629A BR9804629-2A BR9804629A BR9804629A BR 9804629 A BR9804629 A BR 9804629A BR 9804629 A BR9804629 A BR 9804629A BR 9804629 A BR9804629 A BR 9804629A
Authority
BR
Brazil
Prior art keywords
organic
phase
continuously
product mixture
aqueous
Prior art date
Application number
BR9804629-2A
Other languages
English (en)
Inventor
Thomas G Archibald
James C Barnard
Harlan F Reese
Original Assignee
Aerojet General Corportion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerojet General Corportion filed Critical Aerojet General Corportion
Publication of BR9804629A publication Critical patent/BR9804629A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/16—Diazomethane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO CONTìNUO PARA DIAZOMETANO"<D>. O diazometano é produzido em um processo contínuo com pouco ou nenhum risco de explosão, dissolvendo-se uma nitrosamina-N-metil-N em uma mistura de um solvente orgânico miscível em água, que dissolve a nitrosamina-N-metil-N e um solvente orgânico não-miscível em água que dissolve diazometano, e combinando um fluxo desta solução com um fluxo de uma base inorgânica aquosa, permitindo as fases orgânica e aquosa estabelecerem após um tempo de permanência adequado, e fase de separação das fases, tudo em uma base contínua. Quando usando a nitrosouréia-N-metil-N, como a amina, o processo de diazometano é precedido por um processo de nitrosação contínuo, envolvendo combinação de soluções aquosas de metiluréia e um sal de nitrito com uma solução orgânica de um ácido mineral ou orgânico, o solvente na solução sendo uma mistura dos dois solventes orgânicos referidos acima, permitindo as fases aquosas e orgânicas estabelecerem após um tempo de permanência adequado, e fase de separação das fases, tudo em uma base contínua. A fase orgânica resultante é continuamente alimentada para os estágios de diazometano descritos acima.
BR9804629-2A 1997-11-13 1998-11-12 Processo contìnuo para diazometano BR9804629A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/969,993 US5854405A (en) 1997-11-13 1997-11-13 Continuous process for diazomethane from an n-methyl-n-nitrosoamine and from methylurea through n-methyl-n-nitrosourea

Publications (1)

Publication Number Publication Date
BR9804629A true BR9804629A (pt) 2001-03-20

Family

ID=25516271

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9804629-2A BR9804629A (pt) 1997-11-13 1998-11-12 Processo contìnuo para diazometano

Country Status (6)

Country Link
US (1) US5854405A (pt)
EP (1) EP0916648B1 (pt)
JP (1) JP3294560B2 (pt)
AT (1) ATE212329T1 (pt)
BR (1) BR9804629A (pt)
DE (1) DE69803537T2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605732B1 (en) * 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
GB2357501B (en) * 1999-12-23 2001-11-28 Phoenix Chemicals Ltd Generation of diazomethane
DE102004030371A1 (de) * 2004-06-23 2006-01-19 Dynamit Nobel Gmbh Verfahren zur Herstellung von gasförmigen Diazoalkanen
CN101844063B (zh) * 2010-06-24 2013-09-25 凯莱英医药集团（天津）股份有限公司 一种大批量连续安全生产重氮甲烷反应器及其工作方法
CN103189346B (zh) * 2010-11-01 2015-11-25 帝斯曼知识产权资产管理有限公司 重氮化合物的连续生产和反应
GB201318886D0 (en) * 2013-10-25 2013-12-11 Givaudan Sa Improvements i or relating to organic compounds
GB201318894D0 (en) 2013-10-25 2013-12-11 Givaudan Sa Improvements in or relating to organic compounds
US9233924B2 (en) 2014-03-11 2016-01-12 Ampac Fine Chemicals Llc Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof
GB201516396D0 (en) * 2015-09-16 2015-10-28 Givaudan Sa Improvements in or relating to organic compounds
GB201810514D0 (en) 2018-06-27 2018-08-15 Givaudan Sa Improvements in or relating to organic compounds
CN110078637B (zh) * 2019-05-21 2022-08-30 凯莱英医药集团（天津）股份有限公司 重氮甲烷的制备工艺
KR20210124350A (ko) 2019-05-21 2021-10-14 아심켐 래보러토리즈 (톈진) 컴퍼니, 리미티드 디아조메탄의 제조 공정
KR20220042135A (ko) * 2019-07-02 2022-04-04 아심켐 래보러토리즈 (톈진) 컴퍼니, 리미티드 시클로프로판계 화합물의 연속 합성 방법 및 장치
US20230234918A1 (en) * 2020-08-24 2023-07-27 Council Of Scientific And Industrial Research Automated diazomethane generator, reactor and solid phase quencher

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1033671B (de) * 1957-04-02 1958-07-10 Phrix Werke Ag Verfahren zur Herstellung von Diazomethan
JPS54103803A (en) * 1978-02-02 1979-08-15 Minoru Sekiya Nn**nnnitrosoalkylamino*methyl*carbamic acid ester*its manufacture and diazoalkane formation using said compound
JPS6178758A (ja) * 1984-09-27 1986-04-22 Taoka Chem Co Ltd ジアゾメタン誘導体の製造方法
JPS6351366A (ja) * 1986-08-21 1988-03-04 Kurita Water Ind Ltd ジアゾメタンのエ−テル溶液の製造方法
US5459243A (en) * 1994-03-10 1995-10-17 Isis Pharmaceuticals, Inc. Apparatus and processes for the large scale generation and transfer of diazomethane

Also Published As

Publication number Publication date
EP0916648A1 (en) 1999-05-19
DE69803537D1 (de) 2002-03-14
DE69803537T2 (de) 2002-08-08
EP0916648B1 (en) 2002-01-23
JPH11209330A (ja) 1999-08-03
US5854405A (en) 1998-12-29
ATE212329T1 (de) 2002-02-15
JP3294560B2 (ja) 2002-06-24

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