BR9712292A - Forma de dosagem farmacêutica com revestimentos de polímero entérico m·ltiplo para entrega colónica - Google Patents
Forma de dosagem farmacêutica com revestimentos de polímero entérico m·ltiplo para entrega colónicaInfo
- Publication number
- BR9712292A BR9712292A BR9712292-0A BR9712292A BR9712292A BR 9712292 A BR9712292 A BR 9712292A BR 9712292 A BR9712292 A BR 9712292A BR 9712292 A BR9712292 A BR 9712292A
- Authority
- BR
- Brazil
- Prior art keywords
- enteric polymer
- coating layer
- colon
- dosage form
- tablet
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nanotechnology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>"FORMA DE DOSAGEM FARMACêUTICA COM REVESTIMENTOS DE POLìMERO ENTéRICO MúLTIPLO PARA ENTREGA COLÈNICA"<D>. A presente invenção se refere a uma composição farmacêutica em uma forma de dosagem de unidade para a administração peroral em um ser humano ou em um animal, tendo um trato gastrointestinal compreendendo um intestino delgado e um cólon com um lúmen através de todo ele tendo uma entrada para o cólon a partir do intestino delgado, compreendendo: a) uma quantidade segura e eficaz de um agente terapeuticamente ativo incorporado em um tablete bi-convexo, comprimido, com um diâmetro máximo de cerca de 4 mm a cerca de 10 mm; b) uma camada de suavização não dependente de pH aplicada ao tablete para fornecer uma superfície de tablete suave livre de bordas ou de curvas abruptas; e c) um material de revestimento de polímero entérico compreendendo pelo menos uma camada de revestimento interna e somente uma camada de revestimento externa; sendo que o agente terapeuticamente eficaz é liberado em um ponto próximo à entrada para o ou dentro do cólon; cada uma das camadas de revestimento internas é um polímero entérico que começa a se dissolver em um meio aquoso em um pH entre cerca de 5 a cerca de 6,3; e a camada de revestimento externa é um polímero entérico que começa a se dissolver em um meio aquoso em um pH entre cerca de 6,8 a cerca de 7,2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/728,946 US5914132A (en) | 1993-02-26 | 1996-10-11 | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
PCT/US1997/018564 WO1998016206A1 (en) | 1996-10-11 | 1997-10-10 | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712292A true BR9712292A (pt) | 1999-08-31 |
Family
ID=24928914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712292-0A BR9712292A (pt) | 1996-10-11 | 1997-10-10 | Forma de dosagem farmacêutica com revestimentos de polímero entérico m·ltiplo para entrega colónica |
Country Status (9)
Country | Link |
---|---|
US (1) | US5914132A (pt) |
EP (1) | EP0932396B1 (pt) |
JP (1) | JP4276299B2 (pt) |
CN (1) | CN1101675C (pt) |
AT (1) | ATE234079T1 (pt) |
BR (1) | BR9712292A (pt) |
CA (1) | CA2268175C (pt) |
DE (1) | DE69719774T2 (pt) |
WO (1) | WO1998016206A1 (pt) |
Families Citing this family (93)
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AUPP437698A0 (en) | 1998-06-30 | 1998-07-23 | Baumgart, Karl | Methods for treatment of coronary, carotid and other vascular disease |
WO2000040232A2 (en) | 1999-01-08 | 2000-07-13 | Bacaner Marvin B | Bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions |
US6884792B2 (en) * | 1999-01-08 | 2005-04-26 | Marvin B. Bacaner | Bretylium compositions and kits and their use in preventing and treating cardiovascular conditions |
US7138143B1 (en) | 1999-09-30 | 2006-11-21 | Otsuka Pharmaceutical Company, Limited | Coated preparation soluble in the lower digestive tract |
WO2001058429A1 (en) * | 2000-02-10 | 2001-08-16 | Bpsi Holdings, Inc. | Acrylic enteric coating compositions |
US6420473B1 (en) | 2000-02-10 | 2002-07-16 | Bpsi Holdings, Inc. | Acrylic enteric coating compositions |
CN102151247A (zh) * | 2000-06-23 | 2011-08-17 | 生物计划公司 | 包含外消旋卡朵曲的干粉制剂 |
IT1318625B1 (it) | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
CA2359812C (en) * | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
US6887492B2 (en) | 2000-12-14 | 2005-05-03 | Leiner Health Services Corp. | Magnesium plus interactive agent delivery |
WO2002092003A2 (en) * | 2001-05-11 | 2002-11-21 | Bacaner Marvin B | Novel therapeutical quaternary ammonium compositions |
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-
1996
- 1996-10-11 US US08/728,946 patent/US5914132A/en not_active Expired - Fee Related
-
1997
- 1997-10-10 AT AT97910953T patent/ATE234079T1/de not_active IP Right Cessation
- 1997-10-10 CN CN97198666A patent/CN1101675C/zh not_active Expired - Fee Related
- 1997-10-10 WO PCT/US1997/018564 patent/WO1998016206A1/en active IP Right Grant
- 1997-10-10 DE DE69719774T patent/DE69719774T2/de not_active Expired - Fee Related
- 1997-10-10 EP EP97910953A patent/EP0932396B1/en not_active Expired - Lifetime
- 1997-10-10 BR BR9712292-0A patent/BR9712292A/pt not_active Application Discontinuation
- 1997-10-10 CA CA002268175A patent/CA2268175C/en not_active Expired - Fee Related
- 1997-10-10 JP JP51854398A patent/JP4276299B2/ja not_active Expired - Lifetime
Also Published As
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---|---|
EP0932396A1 (en) | 1999-08-04 |
US5914132A (en) | 1999-06-22 |
CN1101675C (zh) | 2003-02-19 |
CA2268175C (en) | 2002-04-23 |
JP2001502333A (ja) | 2001-02-20 |
CA2268175A1 (en) | 1998-04-23 |
ATE234079T1 (de) | 2003-03-15 |
JP4276299B2 (ja) | 2009-06-10 |
DE69719774D1 (de) | 2003-04-17 |
CN1233170A (zh) | 1999-10-27 |
DE69719774T2 (de) | 2003-08-21 |
WO1998016206A1 (en) | 1998-04-23 |
EP0932396B1 (en) | 2003-03-12 |
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