BR9612064A - Processo para preparação de esteróides 9,11-beta-epóxido - Google Patents

Processo para preparação de esteróides 9,11-beta-epóxido

Info

Publication number
BR9612064A
BR9612064A BR9612064A BR9612064A BR9612064A BR 9612064 A BR9612064 A BR 9612064A BR 9612064 A BR9612064 A BR 9612064A BR 9612064 A BR9612064 A BR 9612064A BR 9612064 A BR9612064 A BR 9612064A
Authority
BR
Brazil
Prior art keywords
beta
preparing
epoxide steroids
steroids
epoxide
Prior art date
Application number
BR9612064A
Other languages
English (en)
Portuguese (pt)
Inventor
Xiaoyong Fu
Tiruvettipuram K Thiruvengadam
Chou-Hong Tann
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9612064A publication Critical patent/BR9612064A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
BR9612064A 1995-12-20 1996-12-18 Processo para preparação de esteróides 9,11-beta-epóxido BR9612064A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57556295A 1995-12-20 1995-12-20
PCT/US1996/019600 WO1997022616A1 (en) 1995-12-20 1996-12-18 PROCESS FOR PREPARATION OF 9,11β-EPOXIDE STEROIDS

Publications (1)

Publication Number Publication Date
BR9612064A true BR9612064A (pt) 1999-02-23

Family

ID=24300812

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9612064A BR9612064A (pt) 1995-12-20 1996-12-18 Processo para preparação de esteróides 9,11-beta-epóxido

Country Status (12)

Country Link
EP (1) EP0873352A1 (no)
JP (1) JP2000502102A (no)
KR (1) KR20000064495A (no)
CN (1) CN1209138A (no)
AU (1) AU1331097A (no)
BR (1) BR9612064A (no)
CZ (1) CZ191398A3 (no)
IL (1) IL125004A0 (no)
MX (1) MX9804957A (no)
NO (1) NO982877L (no)
PL (1) PL327141A1 (no)
WO (1) WO1997022616A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
CN103588853A (zh) * 2013-11-28 2014-02-19 浙江省天台县奥锐特药业有限公司 制备9,11β-环氧甾族化合物的方法
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
CN107266519B (zh) * 2016-04-08 2021-06-29 天津金耀集团有限公司 一种9β，11β-环氧-17α-羟基-16α-甲基-21-氯代-1，4孕甾二烯-3，20-二酮新晶型及其制备方法
CN109180767A (zh) * 2018-09-04 2019-01-11 浙江仙琚制药股份有限公司 一种制备糠酸莫米松的方法
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1145170B (de) * 1959-03-13 1963-03-14 Scherico Ltd Verfahren zur Herstellung von 9,11-Oxidosteroiden der Androstan- und Pregnanreihe
GB1244604A (en) * 1967-08-25 1971-09-02 Organon Labor Ltd Substituted methylene steroids and their preparation
GB1416427A (en) * 1972-01-12 1975-12-03 Akzo Nv Alkylated pregnanes and process for obtaining same
DE2617655C2 (de) * 1976-04-21 1984-11-08 F. Hoffmann-La Roche & Co Ag, Basel Kortikoide, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE3064460D1 (en) * 1979-01-24 1983-09-08 Akzo Nv Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same
DD268954A1 (de) * 1983-04-22 1989-06-14 Jenapharm Veb Verfahren zur herstellung von 9alpha-halogen-11beta-formyloxysteroiden der pregnanreihe
FR2675146A1 (fr) * 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.

Also Published As

Publication number Publication date
CN1209138A (zh) 1999-02-24
MX9804957A (es) 1998-09-30
NO982877D0 (no) 1998-06-19
PL327141A1 (en) 1998-11-23
NO982877L (no) 1998-08-20
EP0873352A1 (en) 1998-10-28
AU1331097A (en) 1997-07-14
JP2000502102A (ja) 2000-02-22
IL125004A0 (en) 1999-01-26
CZ191398A3 (cs) 1998-11-11
KR20000064495A (ko) 2000-11-06
WO1997022616A1 (en) 1997-06-26

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law