BR9507659A - Processo para a preparação de um composto composto [r,s-(z)-alpha-(oximino-alpha-(1-azabiciclo)[2.2.2]-oct-3-il) acetonitrila zwitteriónica [r-(z)-alpha-(oximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila zwitteriónica ácido alpha -ciano-1-azabiciclo[2.2.2]-octano-3-acético processo para resolução de [r,s]-alpha-(metoximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila e processoparapresolucão de [r,s-(z)]-alpha (oximino)-alpha(1-azabiciclo[2.2.2]-oct-3-il) acetonitrila e processo para a preparação de [r-(z)]-alpha-(metoxiimino )-alpha-(1-azabiciclo)[ 2.2.2]-oct-3-il) acetonitrila - Google Patents

Processo para a preparação de um composto composto [r,s-(z)-alpha-(oximino-alpha-(1-azabiciclo)[2.2.2]-oct-3-il) acetonitrila zwitteriónica [r-(z)-alpha-(oximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila zwitteriónica ácido alpha -ciano-1-azabiciclo[2.2.2]-octano-3-acético processo para resolução de [r,s]-alpha-(metoximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila e processoparapresolucão de [r,s-(z)]-alpha (oximino)-alpha(1-azabiciclo[2.2.2]-oct-3-il) acetonitrila e processo para a preparação de [r-(z)]-alpha-(metoxiimino )-alpha-(1-azabiciclo)[ 2.2.2]-oct-3-il) acetonitrila

Info

Publication number
BR9507659A
BR9507659A BR9507659A BR9507659A BR9507659A BR 9507659 A BR9507659 A BR 9507659A BR 9507659 A BR9507659 A BR 9507659A BR 9507659 A BR9507659 A BR 9507659A BR 9507659 A BR9507659 A BR 9507659A
Authority
BR
Brazil
Prior art keywords
alpha
acetonitrile
oct
azabicyclo
oximino
Prior art date
Application number
BR9507659A
Other languages
English (en)
Inventor
Steven Mark Bromidge
Erol Ali Faruk
John Kitteringham
Martyn Voyle
Mark Jason Hughes
Gary Thomas Borrett
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR9507659A publication Critical patent/BR9507659A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR9507659A 1994-05-14 1995-05-09 Processo para a preparação de um composto composto [r,s-(z)-alpha-(oximino-alpha-(1-azabiciclo)[2.2.2]-oct-3-il) acetonitrila zwitteriónica [r-(z)-alpha-(oximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila zwitteriónica ácido alpha -ciano-1-azabiciclo[2.2.2]-octano-3-acético processo para resolução de [r,s]-alpha-(metoximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila e processoparapresolucão de [r,s-(z)]-alpha (oximino)-alpha(1-azabiciclo[2.2.2]-oct-3-il) acetonitrila e processo para a preparação de [r-(z)]-alpha-(metoxiimino )-alpha-(1-azabiciclo)[ 2.2.2]-oct-3-il) acetonitrila BR9507659A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9409705A GB9409705D0 (en) 1994-05-14 1994-05-14 Novel compounds
PCT/EP1995/001757 WO1995031456A1 (en) 1994-05-14 1995-05-09 Process for the preparation of azabicyclic derivatives

Publications (1)

Publication Number Publication Date
BR9507659A true BR9507659A (pt) 1997-10-07

Family

ID=10755162

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9507659A BR9507659A (pt) 1994-05-14 1995-05-09 Processo para a preparação de um composto composto [r,s-(z)-alpha-(oximino-alpha-(1-azabiciclo)[2.2.2]-oct-3-il) acetonitrila zwitteriónica [r-(z)-alpha-(oximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila zwitteriónica ácido alpha -ciano-1-azabiciclo[2.2.2]-octano-3-acético processo para resolução de [r,s]-alpha-(metoximino)-alpha-(1-azabiciclo) [2.2.2]-oct-3-il) acetonitrila e processoparapresolucão de [r,s-(z)]-alpha (oximino)-alpha(1-azabiciclo[2.2.2]-oct-3-il) acetonitrila e processo para a preparação de [r-(z)]-alpha-(metoxiimino )-alpha-(1-azabiciclo)[ 2.2.2]-oct-3-il) acetonitrila

Country Status (22)

Country Link
US (2) US5808075A (pt)
EP (1) EP0759921B1 (pt)
JP (1) JPH10500119A (pt)
KR (1) KR100340396B1 (pt)
CN (3) CN1048013C (pt)
AT (1) ATE244718T1 (pt)
AU (1) AU695838B2 (pt)
BR (1) BR9507659A (pt)
CA (1) CA2190278A1 (pt)
CZ (1) CZ334796A3 (pt)
DE (1) DE69531242T2 (pt)
DK (1) DK0759921T3 (pt)
ES (1) ES2202364T3 (pt)
GB (1) GB9409705D0 (pt)
HK (1) HK1012367A1 (pt)
HU (1) HU216629B (pt)
NO (1) NO964818L (pt)
NZ (1) NZ287038A (pt)
PL (1) PL178720B1 (pt)
PT (1) PT759921E (pt)
WO (1) WO1995031456A1 (pt)
ZA (1) ZA953877B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9421472D0 (en) * 1994-10-25 1994-12-07 Smithkline Beecham Plc Novel methods
AU751607B2 (en) * 1995-07-29 2002-08-22 Smithkline Beecham Plc Method of treatment of dementia
GB9615628D0 (en) * 1996-07-25 1996-09-04 Smithkline Beecham Plc Formulation
AU7107998A (en) * 1997-04-11 1998-11-11 Eli Lilly And Company Method for treating schizophrenia
WO2006006071A1 (en) * 2004-07-07 2006-01-19 Pfizer Products Inc. Resolution of an aryl-fused azapolycyclic compound
GB0428170D0 (en) * 2004-12-23 2005-01-26 Biopartners Ltd Mono and Combination Therapy
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904632A (en) * 1972-05-08 1975-09-09 Hoffmann La Roche (')-di-o-isopropylidene-2-keto-l-gulonates
FR2183565B1 (pt) * 1972-05-10 1975-12-26 Cerm Cent Europ Rech Mauvernay
CA1014958A (en) * 1973-10-05 1977-08-02 Jacques Moleyre .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
WO1984000961A1 (en) * 1982-09-07 1984-03-15 Yoshitomi Pharmaceutical 1,4-methano-2-benzazepine derivatives
ES2219636T3 (es) * 1989-04-13 2004-12-01 Beecham Group P.L.C. Nuevos compuestos.
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
MX9300875A (es) * 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.

Also Published As

Publication number Publication date
KR970703342A (ko) 1997-07-03
ZA953877B (en) 1996-03-07
HK1012367A1 (en) 1999-07-30
CZ334796A3 (en) 1997-07-16
NO964818L (no) 1997-01-13
ES2202364T3 (es) 2004-04-01
PL178720B1 (pl) 2000-06-30
HUT75309A (en) 1997-05-28
PL317210A1 (en) 1997-03-17
DE69531242T2 (de) 2004-05-27
EP0759921A1 (en) 1997-03-05
CN1104431C (zh) 2003-04-02
KR100340396B1 (ko) 2002-10-25
HU9603145D0 (en) 1997-01-28
AU2562895A (en) 1995-12-05
NZ287038A (en) 1997-11-24
CA2190278A1 (en) 1995-11-23
CN1048013C (zh) 2000-01-05
GB9409705D0 (en) 1994-07-06
AU695838B2 (en) 1998-08-20
US5773619A (en) 1998-06-30
DE69531242D1 (de) 2003-08-14
HU216629B (hu) 1999-07-28
CN1108302C (zh) 2003-05-14
CN1270170A (zh) 2000-10-18
CN1232825A (zh) 1999-10-27
WO1995031456A1 (en) 1995-11-23
JPH10500119A (ja) 1998-01-06
ATE244718T1 (de) 2003-07-15
NO964818D0 (no) 1996-11-13
EP0759921B1 (en) 2003-07-09
US5808075A (en) 1998-09-15
PT759921E (pt) 2003-11-28
DK0759921T3 (da) 2003-11-03
CN1151743A (zh) 1997-06-11

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Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
FC Decision: refusal
CKFC Appeal: appeal against refusal