BR9402406A - Formas de solvatos de etanol, de metanol e de propanol de cloridrato de loracarbef cristalinos e processos para o isolamento de um composto e para a purificação de uma mistura de loracarbef e d-fenilglicina - Google Patents
Formas de solvatos de etanol, de metanol e de propanol de cloridrato de loracarbef cristalinos e processos para o isolamento de um composto e para a purificação de uma mistura de loracarbef e d-fenilglicinaInfo
- Publication number
- BR9402406A BR9402406A BR9402406A BR9402406A BR9402406A BR 9402406 A BR9402406 A BR 9402406A BR 9402406 A BR9402406 A BR 9402406A BR 9402406 A BR9402406 A BR 9402406A BR 9402406 A BR9402406 A BR 9402406A
- Authority
- BR
- Brazil
- Prior art keywords
- loracarbef
- crystalline
- methanol
- compound
- ethanol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/077,305 US5550231A (en) | 1993-06-15 | 1993-06-15 | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9402406A true BR9402406A (pt) | 1995-01-17 |
Family
ID=22137301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9402406A BR9402406A (pt) | 1993-06-15 | 1994-06-14 | Formas de solvatos de etanol, de metanol e de propanol de cloridrato de loracarbef cristalinos e processos para o isolamento de um composto e para a purificação de uma mistura de loracarbef e d-fenilglicina |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5550231A (pt) |
| EP (1) | EP0629625B1 (pt) |
| JP (1) | JP3474635B2 (pt) |
| KR (1) | KR100310947B1 (pt) |
| AT (1) | ATE225789T1 (pt) |
| BR (1) | BR9402406A (pt) |
| CA (1) | CA2125762A1 (pt) |
| DE (1) | DE69431498T2 (pt) |
| ES (1) | ES2184751T3 (pt) |
| FI (1) | FI108134B (pt) |
| HU (1) | HUT67489A (pt) |
| IL (1) | IL109989A (pt) |
| TW (1) | TW380139B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA978515B (en) * | 1996-09-23 | 1999-03-23 | Lilly Co Eli | Intermediates and process for preparing olanzapine |
| AU2003283624A1 (en) * | 2002-11-21 | 2004-06-15 | Ranbaxy Laboratories Limited | Monohydrate solvates of loracarbef |
| US20060165848A1 (en) * | 2003-03-12 | 2006-07-27 | Lesaffre Et Compagnie | Sour dough the use thereof and bakery products products produced from the same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4168376A (en) * | 1978-06-05 | 1979-09-18 | Eli Lilly And Company | Process for crystalline sodium cefamandole |
| US4316958A (en) * | 1979-02-10 | 1982-02-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing optically active cephalosporin analogs |
| JPS5672698A (en) * | 1979-11-14 | 1981-06-16 | Kyowa Hakko Kogyo Co Ltd | Preparation of optically active cephalosporin analogue |
| US4332896A (en) * | 1979-04-14 | 1982-06-01 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing cephalosporin analogs |
| US4775751A (en) * | 1985-06-03 | 1988-10-04 | Eli Lilly & Company | Process for cephalexin hydrochloride alcoholates |
| CA1334970C (en) * | 1987-10-06 | 1995-03-28 | Carol Elaine Pasini | Crystalline .beta.-lactam hydrate |
| CA2002596A1 (en) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates of b-lactam antibiotic |
| CA2002597C (en) * | 1988-11-14 | 1999-03-23 | Thomas M. Eckrich | Solvates of b-lactam antibiotic |
| US4977257A (en) * | 1988-11-14 | 1990-12-11 | Eli Lilly And Company | DMF solvates of a β-lactam antibiotic |
| CA2034592C (en) * | 1990-01-26 | 2001-06-05 | Ralph R. Pfeiffer | Crystalline hydrochloride of new beta-lactam antibiotic and process therefor |
| US5057607A (en) * | 1990-06-08 | 1991-10-15 | Eli Lilly And Company | Enantiomerically selective biocatalyzed acylation |
| US5399686A (en) * | 1993-06-04 | 1995-03-21 | Eli Lilly And Company | Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate |
| US5352782A (en) * | 1993-06-04 | 1994-10-04 | Eli Lilly And Company | Process for preparing crystalline β-lactam monohydrate |
| US5374719A (en) * | 1993-06-04 | 1994-12-20 | Eli Lilly And Company | Process for converting loracarbef dihydrate to loracarbef monohydrate |
| US5412094A (en) * | 1993-06-28 | 1995-05-02 | Eli Lilly And Company | Bicyclic beta-lactam/paraben complexes |
-
1993
- 1993-06-15 US US08/077,305 patent/US5550231A/en not_active Expired - Lifetime
-
1994
- 1994-06-11 TW TW083105321A patent/TW380139B/zh not_active IP Right Cessation
- 1994-06-13 AT AT94304230T patent/ATE225789T1/de not_active IP Right Cessation
- 1994-06-13 DE DE69431498T patent/DE69431498T2/de not_active Expired - Fee Related
- 1994-06-13 ES ES94304230T patent/ES2184751T3/es not_active Expired - Lifetime
- 1994-06-13 IL IL109989A patent/IL109989A/en not_active IP Right Cessation
- 1994-06-13 CA CA002125762A patent/CA2125762A1/en not_active Abandoned
- 1994-06-13 JP JP13023494A patent/JP3474635B2/ja not_active Expired - Fee Related
- 1994-06-13 HU HU9401765A patent/HUT67489A/hu unknown
- 1994-06-13 KR KR1019940013210A patent/KR100310947B1/ko not_active IP Right Cessation
- 1994-06-13 EP EP94304230A patent/EP0629625B1/en not_active Expired - Lifetime
- 1994-06-13 FI FI942798A patent/FI108134B/fi not_active IP Right Cessation
- 1994-06-14 BR BR9402406A patent/BR9402406A/pt not_active Application Discontinuation
-
1995
- 1995-05-18 US US08/444,124 patent/US5578720A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0629625A1 (en) | 1994-12-21 |
| JP3474635B2 (ja) | 2003-12-08 |
| KR100310947B1 (ko) | 2001-12-28 |
| JPH0770122A (ja) | 1995-03-14 |
| FI108134B (fi) | 2001-11-30 |
| ATE225789T1 (de) | 2002-10-15 |
| TW380139B (en) | 2000-01-21 |
| IL109989A0 (en) | 1994-10-07 |
| US5578720A (en) | 1996-11-26 |
| HU9401765D0 (en) | 1994-09-28 |
| FI942798A (fi) | 1994-12-16 |
| DE69431498T2 (de) | 2003-06-26 |
| KR950000704A (ko) | 1995-01-03 |
| EP0629625B1 (en) | 2002-10-09 |
| ES2184751T3 (es) | 2003-04-16 |
| IL109989A (en) | 1998-06-15 |
| CA2125762A1 (en) | 1994-12-16 |
| DE69431498D1 (de) | 2002-11-14 |
| US5550231A (en) | 1996-08-27 |
| HUT67489A (en) | 1995-04-28 |
| FI942798A0 (fi) | 1994-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal | ||
| CKFC | Appeal: appeal against refusal |