BR112023025827A2 - Composto antagonista de canal trpa1 para uso em doenças degenerativas da retina - Google Patents
Composto antagonista de canal trpa1 para uso em doenças degenerativas da retinaInfo
- Publication number
- BR112023025827A2 BR112023025827A2 BR112023025827A BR112023025827A BR112023025827A2 BR 112023025827 A2 BR112023025827 A2 BR 112023025827A2 BR 112023025827 A BR112023025827 A BR 112023025827A BR 112023025827 A BR112023025827 A BR 112023025827A BR 112023025827 A2 BR112023025827 A2 BR 112023025827A2
- Authority
- BR
- Brazil
- Prior art keywords
- channel antagonist
- trpa1 channel
- antagonist compound
- retinal diseases
- degenerative retinal
- Prior art date
Links
- 108010036769 TRPA1 Cation Channel Proteins 0.000 title abstract 4
- 102000012253 TRPA1 Cation Channel Human genes 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000017442 Retinal disease Diseases 0.000 title abstract 2
- 230000003412 degenerative effect Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 abstract 3
- 208000002780 macular degeneration Diseases 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 230000002207 retinal effect Effects 0.000 abstract 2
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
omposto antagonista de canal trpa1 para uso em doenças degenerativas da retina. a presente invenção se refere a compostos antagonistas de canal trpa1 para uso na prevenção e/ou tratamento de doenças da retina, em particular na prevenção e/ou tratamento da degeneração macular. a presente invenção também se refere a uma composição oftálmica que compreende pelo menos um composto antagonista de canal trpa1 para uso oftálmico tópico na prevenção e/ou tratamento de pelo menos uma doença degenerativa da retina, de preferência degeneração macular
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102021000015098A IT202100015098A1 (it) | 2021-06-09 | 2021-06-09 | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
PCT/IB2022/055276 WO2022259133A1 (en) | 2021-06-09 | 2022-06-07 | Trpa1 channel antagonist compound for use in degenerative retinal diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023025827A2 true BR112023025827A2 (pt) | 2024-02-27 |
Family
ID=77801827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023025827A BR112023025827A2 (pt) | 2021-06-09 | 2022-06-07 | Composto antagonista de canal trpa1 para uso em doenças degenerativas da retina |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP4351540A1 (pt) |
KR (1) | KR20240019817A (pt) |
CN (1) | CN117460501A (pt) |
BR (1) | BR112023025827A2 (pt) |
CA (1) | CA3222168A1 (pt) |
IL (1) | IL308591A (pt) |
IT (1) | IT202100015098A1 (pt) |
WO (1) | WO2022259133A1 (pt) |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011508784A (ja) | 2008-01-04 | 2011-03-17 | アボット・ラボラトリーズ | Trpa1アンタゴニスト |
EP2249820A1 (en) | 2008-01-04 | 2010-11-17 | Abbott Laboratories | Trpa1 antagonists |
JP5559156B2 (ja) | 2008-06-02 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 3,4−ジヒドロピリミジンtrpa1アンタゴニスト |
WO2010141805A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
JP2013507364A (ja) | 2009-10-07 | 2013-03-04 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規なtrpa1アンタゴニスト |
WO2012050641A2 (en) | 2010-06-08 | 2012-04-19 | Hydra Biosciences, Inc | Use of trpa1 antagonists to prevent or treat infections caused by biological-warfare agents |
JP5847827B2 (ja) | 2010-10-12 | 2016-01-27 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | Trpa1受容体アンタゴニスト |
EP2520566A1 (en) | 2011-05-06 | 2012-11-07 | Orion Corporation | New Pharmaceutical Compounds |
CA2843965A1 (en) | 2011-08-09 | 2013-02-14 | Hydra Biosciences, Inc. | Inhibiting transient receptor potential ion channel trpa1 |
JP6182072B2 (ja) | 2012-01-17 | 2017-08-16 | Eaファーマ株式会社 | 複素環アミド誘導体及びそれを含有する医薬 |
CN104684899B (zh) | 2012-09-27 | 2017-07-04 | 霍夫曼-拉罗奇有限公司 | 取代的磺酰胺化合物 |
CN104822653B (zh) | 2012-10-01 | 2017-03-08 | 奥赖恩公司 | N‑丙‑2‑炔基甲酰胺衍生物及其作为trpa1拮抗剂的用途 |
EP2906544A1 (en) | 2012-10-12 | 2015-08-19 | F. Hoffmann-La Roche AG | Substituted phenylcarbamate compounds |
EP2909170A1 (en) | 2012-10-16 | 2015-08-26 | F. Hoffmann-La Roche AG | Substituted carbamate compounds and their use as transient receptor potential (trp) channel antagonists |
WO2014072325A1 (en) | 2012-11-08 | 2014-05-15 | F. Hoffmann-La Roche Ag | [3-heteroaryl-2-trifluoromethyl-propyl]-piperidin-1-yle or -morpholin-4-yle compounds as trpa1 antagonists for the treatment of respiratory diseases |
EP3055302B1 (en) | 2013-10-11 | 2018-12-26 | F. Hoffmann-La Roche AG | Substituted heterocyclic sulfonamide compounds useful as trpa1 modulators |
MX2016004741A (es) | 2013-10-15 | 2016-07-26 | Glenmark Pharmaceuticals Sa | Composicion farmaceutica que comprende un antagonista de trpa1 y un agente analgesico. |
JP6626454B2 (ja) | 2014-01-06 | 2019-12-25 | アルゴメディクス インコーポレイテッド | Trpa1モジュレーター |
BR112016017317B1 (pt) | 2014-01-28 | 2023-04-11 | EA Pharma Co., Ltd | Composto, e, uso de um composto |
TW201620877A (zh) | 2014-03-28 | 2016-06-16 | 奧利安公司 | 新的醫藥化合物 |
TW201620876A (zh) | 2014-03-28 | 2016-06-16 | 奧利安公司 | 新的醫藥化合物 |
WO2015155306A1 (en) | 2014-04-11 | 2015-10-15 | Almirall, S.A. | New trpa1 antagonists |
TWI676626B (zh) | 2014-04-23 | 2019-11-11 | 美商美國禮來大藥廠 | 抑制瞬時受體電位a1離子通道 |
WO2016042501A1 (en) | 2014-09-16 | 2016-03-24 | Glenmark Pharmaceuticals S.A. | Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain |
US10221177B2 (en) | 2014-09-19 | 2019-03-05 | Hydra Biosciences, Inc. | Inhibiting the transient receptor potential A1 ion channel |
WO2016067143A1 (en) | 2014-10-28 | 2016-05-06 | Pfizer Inc. | N-(2-alkyleneimino-3-phenylpropyl)acetamide compounds and their use against pain and pruritus via inhibition of trpa1 channels |
CR20170367A (es) | 2015-02-15 | 2017-09-12 | Hoffmann La Roche | Derivados de 1-(het)arilsulfonil-(pirrolidin o piperidin)-2-carboxamida y su uso como antagonistas de trpa1 |
JPWO2017018495A1 (ja) | 2015-07-29 | 2018-05-17 | Eaファーマ株式会社 | シクロプロパン誘導体及びそれを含有する医薬 |
WO2017060488A1 (en) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
WO2017064068A1 (en) | 2015-10-14 | 2017-04-20 | Almirall, S.A. | New trpa1 antagonists |
WO2017135462A1 (ja) | 2016-02-05 | 2017-08-10 | Eaファーマ株式会社 | 複素環スルホンアミド誘導体及びそれを含有する医薬 |
SG11201811655SA (en) | 2016-07-06 | 2019-01-30 | Algomedix Inc | Trpa1 antagonists for treatment of dry eye, ocular pain and inflammation |
WO2018015410A1 (en) | 2016-07-20 | 2018-01-25 | F. Hoffmann-La Roche Ag | Bicyclic proline compounds |
WO2018015411A1 (en) | 2016-07-20 | 2018-01-25 | F. Hoffmann-La Roche Ag | Sulfonylcycloalkyl carboxamide compounds as trpa1 modulators |
JP7071959B2 (ja) | 2016-08-12 | 2022-05-19 | エフ.ホフマン-ラ ロシュ アーゲー | スルホニルピリジルtrp阻害剤 |
TW201831477A (zh) | 2016-11-28 | 2018-09-01 | 瑞士商赫孚孟拉羅股份公司 | 噁二唑酮瞬時受體電位通道抑制劑 |
EP3592739A1 (en) | 2017-03-07 | 2020-01-15 | H. Hoffnabb-La Roche Ag | Oxadiazole transient receptor potential channel inhibitors |
JP7025555B2 (ja) | 2018-01-31 | 2022-02-24 | イーライ リリー アンド カンパニー | 一過性受容体電位a1イオンチャネルの阻害 |
US10710994B2 (en) | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
CN110357833B (zh) | 2019-06-03 | 2022-05-24 | 杭州维坦医药科技有限公司 | 芳杂乙酰胺类衍生物及其制备和应用 |
CN114555601B (zh) | 2019-10-15 | 2024-04-02 | 勃林格殷格翰国际有限公司 | 新颖的四唑类 |
-
2021
- 2021-06-09 IT IT102021000015098A patent/IT202100015098A1/it unknown
-
2022
- 2022-06-07 CN CN202280041242.8A patent/CN117460501A/zh active Pending
- 2022-06-07 WO PCT/IB2022/055276 patent/WO2022259133A1/en active Application Filing
- 2022-06-07 CA CA3222168A patent/CA3222168A1/en active Pending
- 2022-06-07 KR KR1020247000880A patent/KR20240019817A/ko unknown
- 2022-06-07 BR BR112023025827A patent/BR112023025827A2/pt unknown
- 2022-06-07 EP EP22735595.5A patent/EP4351540A1/en active Pending
- 2022-06-07 IL IL308591A patent/IL308591A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IT202100015098A1 (it) | 2022-12-09 |
EP4351540A1 (en) | 2024-04-17 |
CN117460501A (zh) | 2024-01-26 |
CA3222168A1 (en) | 2022-12-15 |
WO2022259133A1 (en) | 2022-12-15 |
IL308591A (en) | 2024-01-01 |
KR20240019817A (ko) | 2024-02-14 |
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