BR112023005228A2 - Forma de dosagem oral de uma composição farmacêutica para controlar diabetes ou pré-diabetes em um indivíduo - Google Patents

Forma de dosagem oral de uma composição farmacêutica para controlar diabetes ou pré-diabetes em um indivíduo

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Publication number
BR112023005228A2
BR112023005228A2 BR112023005228A BR112023005228A BR112023005228A2 BR 112023005228 A2 BR112023005228 A2 BR 112023005228A2 BR 112023005228 A BR112023005228 A BR 112023005228A BR 112023005228 A BR112023005228 A BR 112023005228A BR 112023005228 A2 BR112023005228 A2 BR 112023005228A2
Authority
BR
Brazil
Prior art keywords
dosage form
oral dosage
pharmaceutical composition
antidiabetic
individual
Prior art date
Application number
BR112023005228A
Other languages
English (en)
Inventor
Tian Wu
Wang Yan
Original Assignee
Elite Pharmaceutical Solution Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elite Pharmaceutical Solution Inc filed Critical Elite Pharmaceutical Solution Inc
Publication of BR112023005228A2 publication Critical patent/BR112023005228A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

FORMA DE DOSAGEM ORAL DE UMA COMPOSIÇÃO FARMACÊUTICA PARA CONTROLAR DIABETES OU PRÉ-DIABETES EM UM INDIVÍDUO. Uma forma de dosagem oral de uma composição farmacêutica antidiabética compreende uma porção de núcleo, uma porção externa e um filme de membrana controlado entre elas. As porções de núcleo e externa compreendem, respectivamente, um primeiro agente antidiabético e um segundo agente antidiabético, tal como HCl de metformina e fosfato de sitagliptina, cada um em uma quantidade terapeuticamente eficaz. O filme de membrana controlado encapsula a porção de núcleo e é fornecida com pelo menos uma passagem para permitir a liberação do primeiro agente antidiabético quando a forma de dosagem oral está em um ambiente aquoso, tal como no trato gastrointestinal (GI) de um sujeito. A forma de dosagem oral é configurada, após uma administração oral de dose única, para fornecer uma concentração plasmática máxima do primeiro agente antidiabético no sujeito de aproximadamente 7,5 a 15 horas após a administração. Um método para fabricar a forma de dosagem oral da composição farmacêutica antidiabética também é fornecido.
BR112023005228A 2020-09-22 2021-08-27 Forma de dosagem oral de uma composição farmacêutica para controlar diabetes ou pré-diabetes em um indivíduo BR112023005228A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17/028,403 US11684596B2 (en) 2020-09-22 2020-09-22 Antidiabetic pharmaceutical compositions and preparation method thereof
PCT/US2021/048104 WO2022066363A1 (en) 2020-09-22 2021-08-27 Antidiabetic pharmaceutical compositions and preparation method thereof

Publications (1)

Publication Number Publication Date
BR112023005228A2 true BR112023005228A2 (pt) 2023-04-25

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BR112023005228A BR112023005228A2 (pt) 2020-09-22 2021-08-27 Forma de dosagem oral de uma composição farmacêutica para controlar diabetes ou pré-diabetes em um indivíduo

Country Status (9)

Country Link
US (1) US11684596B2 (pt)
EP (1) EP4216942A1 (pt)
JP (1) JP2023541928A (pt)
KR (1) KR20230093255A (pt)
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