BR112023001048A2 - Agonista de ppar-delta cristalino - Google Patents
Agonista de ppar-delta cristalinoInfo
- Publication number
- BR112023001048A2 BR112023001048A2 BR112023001048A BR112023001048A BR112023001048A2 BR 112023001048 A2 BR112023001048 A2 BR 112023001048A2 BR 112023001048 A BR112023001048 A BR 112023001048A BR 112023001048 A BR112023001048 A BR 112023001048A BR 112023001048 A2 BR112023001048 A2 BR 112023001048A2
- Authority
- BR
- Brazil
- Prior art keywords
- crystalline
- ppar
- delta agonist
- agonist
- delta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
AGONISTA DE PPAR-DELTA CRISTALINO. É descrito nesse documento (E)-2-(4-((3-(4-fluorofenil)-3-(4-(3-morfolinoprop-1-in-1-il)fenil)alil)óxi)-2-metilfenóxi)acetato de sódio cristalino, usos de tal material cristalino na preparação de composições farmacêuticas para o tratamento de doenças ou condições que se beneficiariam da administração com um composto agonista de PPARdelta.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063055235P | 2020-07-22 | 2020-07-22 | |
US202063118431P | 2020-11-25 | 2020-11-25 | |
PCT/US2021/042412 WO2022020376A1 (en) | 2020-07-22 | 2021-07-20 | Crystalline ppar-delta agonist |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023001048A2 true BR112023001048A2 (pt) | 2023-04-04 |
Family
ID=79687855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023001048A BR112023001048A2 (pt) | 2020-07-22 | 2021-07-20 | Agonista de ppar-delta cristalino |
Country Status (12)
Country | Link |
---|---|
US (3) | US11267795B2 (pt) |
EP (1) | EP4185572A1 (pt) |
JP (1) | JP2023534835A (pt) |
KR (1) | KR20230054373A (pt) |
CN (1) | CN116249695A (pt) |
AU (1) | AU2021312855A1 (pt) |
BR (1) | BR112023001048A2 (pt) |
CA (1) | CA3185909A1 (pt) |
IL (1) | IL300000A (pt) |
MX (1) | MX2023001001A (pt) |
TW (1) | TW202219038A (pt) |
WO (1) | WO2022020376A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022020376A1 (en) | 2020-07-22 | 2022-01-27 | Reneo Pharmaceuticals, Inc. | Crystalline ppar-delta agonist |
WO2023147309A1 (en) * | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2331336A1 (fr) | 1975-11-14 | 1977-06-10 | Rolland Sa A | Acides oxy-4,4' bis(phenoxy-2 alcanocarboxyliques), leurs derives et leur application comme medicament |
US4920132A (en) | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US5324743A (en) | 1992-12-10 | 1994-06-28 | Eli Lilly And Company | Leukotriene B4 antagonists |
IL109451A0 (en) | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
US5773469A (en) | 1996-06-18 | 1998-06-30 | Ortho Pharmaceutical Corporation | Diaryl antimicrobial agents |
JP2002542218A (ja) | 1999-04-20 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 新規な化合物、それらの製造および使用 |
US6972294B1 (en) | 1999-04-20 | 2005-12-06 | Novo Nordisk, A/S | Compounds, their preparation and use |
AU3507700A (en) | 1999-06-01 | 2000-12-18 | University Of Texas Southwestern Medical Center, The | Method of treating hair loss using diphenylether derivatives |
MXPA02007295A (es) | 2000-01-28 | 2002-11-29 | Novo Nordisk As | Derivados de acido propionico alquinilsubstituidos y su uso contra diabetes y obesidad. |
US6555577B1 (en) | 2000-01-28 | 2003-04-29 | Novo Nordisk A/S | Compounds, their preparation and use |
JP2003520838A (ja) | 2000-01-28 | 2003-07-08 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、それらの製造および使用。 |
US6569901B2 (en) | 2000-01-28 | 2003-05-27 | Novo Nordisk A/S | Alkynyl-substituted propionic acid derivatives, their preparation and use |
US6448293B1 (en) | 2000-03-31 | 2002-09-10 | Pfizer Inc. | Diphenyl ether compounds useful in therapy |
WO2001079150A1 (en) | 2000-04-17 | 2001-10-25 | Novo Nordisk A/S | New compounds, their preparation and use |
DE60129712T2 (de) | 2000-08-23 | 2008-07-03 | Eli Lilly And Co., Indianapolis | Oxazolylaryloxyessigsäure derivate und ihre verwendung als ppar agonisten |
US6630504B2 (en) | 2000-08-31 | 2003-10-07 | Pfizer Inc. | Phenoxyphenylheterocyclyl derivatives as SSRIs |
US6869967B2 (en) | 2001-07-30 | 2005-03-22 | Novo Nordisk A/S | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives |
RU2004105956A (ru) * | 2001-07-30 | 2005-03-27 | Ново Нордиск А/С (DK) | Новые производные винилкарбоновых кислот и их применение в качестве антидиабетических средств и т.п. |
EP1414785A1 (en) | 2001-07-30 | 2004-05-06 | Novo Nordisk A/S | Novel vinyl n-(2-benzoylphenyl)-l-tyrosine derivatives and their use as antidiabetics etc |
US7067530B2 (en) | 2001-07-30 | 2006-06-27 | Novo Nordisk A/S | Compounds, their preparation and use |
CA2460313C (en) | 2001-09-14 | 2011-03-08 | Tularik Inc. | Bisphenylsulfanyl and sulphonate compounds and use thereof for elevating hdl cholesterol levels |
JP2005505616A (ja) | 2001-10-17 | 2005-02-24 | ノボ ノルディスク アクティーゼルスカブ | ジカルボン酸誘導体、それらの調製、並びに治療上の用途 |
US7220877B2 (en) | 2001-10-17 | 2007-05-22 | Novo Nordisk A/S | Compounds, their preparation and use |
US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
EP1537076A1 (en) | 2002-09-05 | 2005-06-08 | Novo Nordisk A/S | Novel vinyl carboxylic acid derivatives and their therapeutical use |
JP4708184B2 (ja) | 2002-10-28 | 2011-06-22 | ハイ ポイント ファーマシューティカルズ,エルエルシー | 新規の化合物、それらの調製及び使用 |
US20050080115A1 (en) | 2002-10-28 | 2005-04-14 | Lone Jeppesen | Novel compounds, their preparation and use |
US7129268B2 (en) | 2002-10-28 | 2006-10-31 | Novo Nordisk A/S | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives |
PL376704A1 (pl) * | 2002-10-28 | 2006-01-09 | Novo Nordisk A/S | Nowe związki przydatne w leczeniu chorób, w których pośredniczy PPAR |
EP1745002B1 (en) | 2004-05-05 | 2010-11-03 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
ATE515494T1 (de) | 2004-05-05 | 2011-07-15 | High Point Pharmaceuticals Llc | Neue verbindungen, deren herstellung und verwendung |
WO2005105735A1 (en) * | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Phenoxyacetic acid derivatives as ppar agonists |
MX2007016374A (es) | 2005-06-30 | 2008-03-05 | Novo Nordisk As | Acidos fenoxiaceticos como activadores ppar delta. |
EA015717B1 (ru) | 2005-12-22 | 2011-10-31 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Феноксиуксусные кислоты в качестве активаторов ppar дельта |
CA2645719A1 (en) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Compounds that modulate ppar activity, their preparation and use |
US20100197950A1 (en) | 2006-06-08 | 2010-08-05 | Kaare Gyberg Rasmussen | Process for preparing phenoxy acetic acid derivatives |
US9487493B2 (en) | 2013-09-09 | 2016-11-08 | Vtv Therapeutics Llc | Use of a PPAR-delta agonist for treating muscle atrophy |
US9669288B2 (en) | 2014-11-18 | 2017-06-06 | Ags, Llc | Method, apparatus, clustered devices, and computer readable storage for conducting a wagering game |
WO2022020376A1 (en) | 2020-07-22 | 2022-01-27 | Reneo Pharmaceuticals, Inc. | Crystalline ppar-delta agonist |
-
2021
- 2021-07-20 WO PCT/US2021/042412 patent/WO2022020376A1/en unknown
- 2021-07-20 MX MX2023001001A patent/MX2023001001A/es unknown
- 2021-07-20 KR KR1020237006116A patent/KR20230054373A/ko unknown
- 2021-07-20 JP JP2023504196A patent/JP2023534835A/ja active Pending
- 2021-07-20 IL IL300000A patent/IL300000A/en unknown
- 2021-07-20 CA CA3185909A patent/CA3185909A1/en active Pending
- 2021-07-20 US US17/381,005 patent/US11267795B2/en active Active
- 2021-07-20 EP EP21846698.5A patent/EP4185572A1/en active Pending
- 2021-07-20 BR BR112023001048A patent/BR112023001048A2/pt unknown
- 2021-07-20 CN CN202180064865.2A patent/CN116249695A/zh active Pending
- 2021-07-20 AU AU2021312855A patent/AU2021312855A1/en active Pending
- 2021-07-21 TW TW110126838A patent/TW202219038A/zh unknown
-
2022
- 2022-01-10 US US17/572,037 patent/US11713301B2/en active Active
-
2023
- 2023-06-12 US US18/333,454 patent/US20240002356A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN116249695A (zh) | 2023-06-09 |
IL300000A (en) | 2023-03-01 |
CA3185909A1 (en) | 2022-01-27 |
JP2023534835A (ja) | 2023-08-14 |
US20220135532A1 (en) | 2022-05-05 |
WO2022020376A1 (en) | 2022-01-27 |
AU2021312855A1 (en) | 2023-03-09 |
US20220024888A1 (en) | 2022-01-27 |
US20240002356A1 (en) | 2024-01-04 |
KR20230054373A (ko) | 2023-04-24 |
TW202219038A (zh) | 2022-05-16 |
US11267795B2 (en) | 2022-03-08 |
EP4185572A1 (en) | 2023-05-31 |
US11713301B2 (en) | 2023-08-01 |
MX2023001001A (es) | 2023-03-01 |
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