BR112023000584A2 - Bioprocesso com depósito de impurezas reduzido nas superfícies - Google Patents

Bioprocesso com depósito de impurezas reduzido nas superfícies

Info

Publication number
BR112023000584A2
BR112023000584A2 BR112023000584A BR112023000584A BR112023000584A2 BR 112023000584 A2 BR112023000584 A2 BR 112023000584A2 BR 112023000584 A BR112023000584 A BR 112023000584A BR 112023000584 A BR112023000584 A BR 112023000584A BR 112023000584 A2 BR112023000584 A2 BR 112023000584A2
Authority
BR
Brazil
Prior art keywords
bioprocess
impurites
reduced deposit
formula
aqueous solution
Prior art date
Application number
BR112023000584A
Other languages
English (en)
Inventor
S Katz Joshua
L Jordan Susan
Fares Hadi
Yezer Benjamin
Original Assignee
Nutrition & Biosciences Usa 1 Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrition & Biosciences Usa 1 Llc filed Critical Nutrition & Biosciences Usa 1 Llc
Publication of BR112023000584A2 publication Critical patent/BR112023000584A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/34—Polyvinylidene fluoride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

BIOPROCESSO COM DEPÓSITO DE IMPUREZAS REDUZIDO NAS SUPERFÍCIES. A presente invenção refere-se a descrição a um processo que envolve: (a) fornecer uma solução aquosa de uma proteína e um tensoativo de polialcóxi acila graxa da fórmula I em que R1-C(=O) é um grupo acila graxa, R2 é H ou um grupo hidrocarbila substituído ou não substituído, X1 é O ou NH, X2 é O ou NH, n é 0 ou um número inteiro de 1-5, R3 é um grupo polimérico que compreende unidades polimerizadas da fórmula II e III e (b) submeter a solução aquosa a um bioprocesso.
BR112023000584A 2020-07-15 2021-07-14 Bioprocesso com depósito de impurezas reduzido nas superfícies BR112023000584A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063052048P 2020-07-15 2020-07-15
PCT/US2021/041508 WO2022015779A1 (en) 2020-07-15 2021-07-14 Bioprocess with reduced fouling on surfaces

Publications (1)

Publication Number Publication Date
BR112023000584A2 true BR112023000584A2 (pt) 2023-03-28

Family

ID=77466035

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023000584A BR112023000584A2 (pt) 2020-07-15 2021-07-14 Bioprocesso com depósito de impurezas reduzido nas superfícies

Country Status (9)

Country Link
US (1) US20230242580A1 (pt)
EP (1) EP4182329A1 (pt)
JP (1) JP2023535561A (pt)
KR (1) KR20230043132A (pt)
CN (1) CN116348475A (pt)
BR (1) BR112023000584A2 (pt)
CA (1) CA3185567A1 (pt)
IL (1) IL299852A (pt)
WO (1) WO2022015779A1 (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012134987A1 (en) * 2011-03-25 2012-10-04 Genentech, Inc. Novel protein purification methods
KR20180051543A (ko) * 2015-09-11 2018-05-16 다우 글로벌 테크놀로지스 엘엘씨 단백질 및 폴리알콕시 지방 화합물을 포함하는 조성물
JP6846409B2 (ja) 2015-09-11 2021-03-24 ダウ グローバル テクノロジーズ エルエルシー ポリアルコキシ脂肪族化合物
WO2018156467A1 (en) * 2017-02-24 2018-08-30 Merck Sharp & Dohme Corp. Methods for improving filterability of polysaccharide-protein conjugate reactions
KR20210056349A (ko) * 2018-09-10 2021-05-18 다우 글로벌 테크놀로지스 엘엘씨 단백질 및 폴리알콕시 지방 아실 계면활성제를 포함하는 조성물
CN115279780A (zh) * 2019-12-12 2022-11-01 营养与生物科学美国1有限责任公司 蛋白质生物工艺

Also Published As

Publication number Publication date
US20230242580A1 (en) 2023-08-03
CA3185567A1 (en) 2022-01-20
EP4182329A1 (en) 2023-05-24
CN116348475A (zh) 2023-06-27
JP2023535561A (ja) 2023-08-18
IL299852A (en) 2023-03-01
WO2022015779A1 (en) 2022-01-20
KR20230043132A (ko) 2023-03-30

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