BR112022026611A2 - Anticorpo ou fragmento de ligação ao antígeno do mesmo, conjugado de anticorpo, composição, receptor de antígeno quimérico, célula efetora imune, molécula de ácido nucleico, vetor de expressão, célula hospedeira, anticorpo multiespecífico, proteína de fusão, composição farmacêutica, uso do anticorpo ou fragmento de ligação ao antígeno do mesmo e método para detectar a presença ou determinar o nível de expressão de nectina-4 em uma amostra - Google Patents

Anticorpo ou fragmento de ligação ao antígeno do mesmo, conjugado de anticorpo, composição, receptor de antígeno quimérico, célula efetora imune, molécula de ácido nucleico, vetor de expressão, célula hospedeira, anticorpo multiespecífico, proteína de fusão, composição farmacêutica, uso do anticorpo ou fragmento de ligação ao antígeno do mesmo e método para detectar a presença ou determinar o nível de expressão de nectina-4 em uma amostra

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Publication number
BR112022026611A2
BR112022026611A2 BR112022026611A BR112022026611A BR112022026611A2 BR 112022026611 A2 BR112022026611 A2 BR 112022026611A2 BR 112022026611 A BR112022026611 A BR 112022026611A BR 112022026611 A BR112022026611 A BR 112022026611A BR 112022026611 A2 BR112022026611 A2 BR 112022026611A2
Authority
BR
Brazil
Prior art keywords
antibody
antigen
binding fragment
composition
nectin
Prior art date
Application number
BR112022026611A
Other languages
English (en)
Inventor
Wang Cheng
Liu Dengnian
Li Fen
Xiao Liang
XUE Tongtong
Ge Junyou
Wang Jingyi
Liu Le
Ren Qi
Original Assignee
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Kelun Biotech Biopharmaceutical Co Ltd filed Critical Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Publication of BR112022026611A2 publication Critical patent/BR112022026611A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

ANTICORPO OU FRAGMENTO DE LIGAÇÃO AO ANTÍGENO DO MESMO,CONJUGADO DE ANTICORPO, COMPOSIÇÃO, RECEPTOR DE ANTÍGENO QUIMÉRICO, CÉLULA EFETORA IMUNE, MOLÉCULA DE ÁCIDO NUCLEICO, VETOR DE EXPRESSÃO, CÉLULA HOSPEDEIRA, ANTICORPO MULTIESPECÍFICO, PROTEÍNA DE FUSÃO, COMPOSIÇÃO FARMACÊUTICA, USO DO ANTICORPO OU FRAGMENTO DE LIGAÇÃO AO ANTÍGENO DO MESMO E MÉTODO PARA DETECTAR A PRESENÇA OU DETERMINAR O NÍVEL DE EXPRESSÃO DE NECTINA-4 EM UMA AMOSTRA. É provido um anticorpo anti-Nectina-4 ou fragmento de ligação ao antígeno do mesmo, um conjugado de anticorpo compreendendo o mesmo e seu uso na fabricação de um medicamento, particularmente na fabricação de um medicamento para tratamento e/ou prevenção de câncer.
BR112022026611A 2020-09-16 2021-09-06 Anticorpo ou fragmento de ligação ao antígeno do mesmo, conjugado de anticorpo, composição, receptor de antígeno quimérico, célula efetora imune, molécula de ácido nucleico, vetor de expressão, célula hospedeira, anticorpo multiespecífico, proteína de fusão, composição farmacêutica, uso do anticorpo ou fragmento de ligação ao antígeno do mesmo e método para detectar a presença ou determinar o nível de expressão de nectina-4 em uma amostra BR112022026611A2 (pt)

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