BR112022023995A2 - Uso de nanopartículas magnéticas para detecção e quantificação de analito(s) - Google Patents
Uso de nanopartículas magnéticas para detecção e quantificação de analito(s)Info
- Publication number
- BR112022023995A2 BR112022023995A2 BR112022023995A BR112022023995A BR112022023995A2 BR 112022023995 A2 BR112022023995 A2 BR 112022023995A2 BR 112022023995 A BR112022023995 A BR 112022023995A BR 112022023995 A BR112022023995 A BR 112022023995A BR 112022023995 A2 BR112022023995 A2 BR 112022023995A2
- Authority
- BR
- Brazil
- Prior art keywords
- analyte
- magnetizable particles
- magnetic
- bound
- magnetic field
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
- G01N33/547—Synthetic resin with antigen or antibody attached to the carrier via a bridging agent
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/53—Colony-stimulating factor [CSF]
- G01N2333/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5412—IL-6
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
- G01N2333/765—Serum albumin, e.g. HSA
Abstract
USO DENANOPARTÍCULAS MAGNÉTICAS PARA DETECÇÃO E QUANTIFICAÇÃO DE ANALITO(S). A presente invenção refere-se a um método e um dispositivo para detectar um analito em uma amostra, compreendendo trazer uma amostra compreendendo um analito alvo em contato com partículas magnetizáveis, as partículas sendo revestidas de moléculas de ligação complementares ao analito alvo, resultando em complexos ligantes ligados e não ligados, posicionar as partículas magnetizáveis, compreendendo tanto complexos ligantes ligados quanto não ligados, na proximidade de um sensor de campo magnético mudando o campo magnético o suficiente para liberar pelo menos uma porção das partículas magnetizáveis, compreendendo ambos os complexos ligantes ligados e não ligados, de sua proximidade com o sensor de campo magnético, e medindo mudanças em um sinal magnético detectado a partir do movimento líquido, seja translacional ou rotacional, das partículas magnetizáveis em relação ao sensor magnético.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2020904881 | 2020-05-25 | ||
PCT/AU2021/050497 WO2021237283A1 (en) | 2020-05-25 | 2021-05-25 | Use of magnetic nanoparticles for the detection and quantitation of analyte(s) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022023995A2 true BR112022023995A2 (pt) | 2023-02-07 |
Family
ID=78745678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022023995A BR112022023995A2 (pt) | 2020-05-25 | 2021-05-25 | Uso de nanopartículas magnéticas para detecção e quantificação de analito(s) |
Country Status (12)
Country | Link |
---|---|
US (2) | US11604187B2 (pt) |
EP (1) | EP3938785A4 (pt) |
JP (1) | JP2023528687A (pt) |
KR (1) | KR20230013259A (pt) |
CN (1) | CN114341641A (pt) |
AU (2) | AU2021232687B2 (pt) |
BR (1) | BR112022023995A2 (pt) |
CA (1) | CA3180264A1 (pt) |
IL (1) | IL298373A (pt) |
MX (1) | MX2022014818A (pt) |
TW (1) | TW202215051A (pt) |
WO (1) | WO2021237283A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114214391A (zh) * | 2021-12-14 | 2022-03-22 | 徐州医科大学 | Au/Fe3O4复合的磁纳米马达材料、制备方法及应用 |
CN117434141A (zh) * | 2023-10-13 | 2024-01-23 | 中国计量科学研究院 | 样品检测方法、装置、计算机设备和存储介质 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6825655B2 (en) * | 2001-08-31 | 2004-11-30 | Imego Ab | Method and arrangement for detecting changes of a magnetic response in magnetic particles |
EP1469311B1 (en) * | 2002-01-29 | 2007-08-08 | Asahi Kasei Kabushiki Kaisha | Biosensor, magnetic molecule measurement method, and measurement object measuring method |
US7906345B2 (en) * | 2003-11-12 | 2011-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules |
JP3962385B2 (ja) * | 2004-03-11 | 2007-08-22 | 株式会社日立製作所 | 免疫検査装置及び免疫検査方法 |
JP2009507208A (ja) * | 2005-05-27 | 2009-02-19 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 細胞および組成物の光学コヒーレンス断層撮影法による検出 |
EP1910832A1 (en) * | 2005-07-20 | 2008-04-16 | Inverness Medical Switzerland GmbH | Assay device and method |
US20070197900A1 (en) * | 2005-11-22 | 2007-08-23 | Vanderbilt University | Magnetic flow cytometer with SQUID microscopy |
JP4837410B2 (ja) * | 2006-03-22 | 2011-12-14 | 富士フイルム株式会社 | 標的化合物の検出方法 |
WO2011053435A1 (en) * | 2009-10-05 | 2011-05-05 | Scientific Nanomedicine, Inc. | Cell detection using targeted nanoparticles and magnetic properties thereof |
EP2419733A4 (en) * | 2009-04-13 | 2013-12-25 | Univ Leland Stanford Junior | METHODS AND DEVICES FOR DETECTING THE PRESENCE OF AN ANALYTE IN A SAMPLE |
US8153442B2 (en) * | 2009-10-21 | 2012-04-10 | Siemens Healthcare Diagnostics Inc. | Stabilization of signal generation in particles used in assays |
JP2013512450A (ja) * | 2009-11-30 | 2013-04-11 | バイオ−ラッド ラボラトリーズ,インコーポレイティド | ビーズリーダ |
WO2012012596A2 (en) * | 2010-07-22 | 2012-01-26 | University Of Houston System | Force-induced magnetization contrast for diagnosis and imaging |
GB201014805D0 (en) * | 2010-09-07 | 2010-10-20 | Multi Sense Technologies Ltd | Microfluidics based assay device |
US9039992B2 (en) * | 2011-06-06 | 2015-05-26 | Abbott Laboratories | Apparatus for closed tube sampling and open tube sampling for automated clinical analyzers |
EP3295163B1 (en) * | 2015-05-12 | 2020-12-02 | Magarray, Inc. | Devices and methods for increasing magnetic sensor sensitivity |
CN108474779B (zh) * | 2016-03-08 | 2021-01-26 | 马格雷股份有限公司 | 用于肺癌的诊断和治疗的蛋白质和自体抗体生物标志物 |
GB201707140D0 (en) * | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
-
2021
- 2021-05-25 MX MX2022014818A patent/MX2022014818A/es unknown
- 2021-05-25 EP EP21765819.4A patent/EP3938785A4/en active Pending
- 2021-05-25 BR BR112022023995A patent/BR112022023995A2/pt unknown
- 2021-05-25 AU AU2021232687A patent/AU2021232687B2/en active Active
- 2021-05-25 JP JP2023515223A patent/JP2023528687A/ja active Pending
- 2021-05-25 KR KR1020227044248A patent/KR20230013259A/ko unknown
- 2021-05-25 IL IL298373A patent/IL298373A/en unknown
- 2021-05-25 CA CA3180264A patent/CA3180264A1/en active Pending
- 2021-05-25 CN CN202180003838.4A patent/CN114341641A/zh active Pending
- 2021-05-25 WO PCT/AU2021/050497 patent/WO2021237283A1/en active Application Filing
- 2021-05-26 TW TW110119112A patent/TW202215051A/zh unknown
- 2021-08-31 US US17/462,209 patent/US11604187B2/en active Active
-
2023
- 2023-02-15 US US18/169,445 patent/US20230251249A1/en active Pending
-
2024
- 2024-02-21 AU AU2024201129A patent/AU2024201129A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN114341641A (zh) | 2022-04-12 |
JP2023528687A (ja) | 2023-07-05 |
IL298373A (en) | 2023-01-01 |
AU2024201129A1 (en) | 2024-03-14 |
KR20230013259A (ko) | 2023-01-26 |
CA3180264A1 (en) | 2021-12-02 |
WO2021237283A1 (en) | 2021-12-02 |
US20220003758A1 (en) | 2022-01-06 |
EP3938785A4 (en) | 2022-11-30 |
EP3938785A1 (en) | 2022-01-19 |
US11604187B2 (en) | 2023-03-14 |
MX2022014818A (es) | 2023-04-03 |
AU2021232687A1 (en) | 2021-12-09 |
AU2021232687B2 (en) | 2023-11-23 |
TW202215051A (zh) | 2022-04-16 |
US20230251249A1 (en) | 2023-08-10 |
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