BR112022022030A2 - Anticorpo humanizado do receptor anti-igf-1, molécula de ácido nucleico, vetor de clonagem ou vetor de expressão, célula recombinante, processo para produzir um anticorpo humanizado do receptor anti-igf-1, e, composição farmacêutica - Google Patents

Anticorpo humanizado do receptor anti-igf-1, molécula de ácido nucleico, vetor de clonagem ou vetor de expressão, célula recombinante, processo para produzir um anticorpo humanizado do receptor anti-igf-1, e, composição farmacêutica

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Publication number
BR112022022030A2
BR112022022030A2 BR112022022030A BR112022022030A BR112022022030A2 BR 112022022030 A2 BR112022022030 A2 BR 112022022030A2 BR 112022022030 A BR112022022030 A BR 112022022030A BR 112022022030 A BR112022022030 A BR 112022022030A BR 112022022030 A2 BR112022022030 A2 BR 112022022030A2
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Brazil
Prior art keywords
igf
humanized anti
receptor antibody
antibody
nucleic acid
Prior art date
Application number
BR112022022030A
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English (en)
Inventor
MATSUKAWA Hiroaki
Eguchi Hiroshi
Namiki Naoko
Tanokura Akira
Original Assignee
Teijin Pharma Ltd
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Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of BR112022022030A2 publication Critical patent/BR112022022030A2/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/75Agonist effect on antigen
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

ANTICORPO HUMANIZADO DO RECEPTOR ANTI-IGF-1, MOLÉCULA DE ÁCIDO NUCLEICO, VETOR DE CLONAGEM OU VETOR DE EXPRESSÃO, CÉLULA RECOMBINANTE, PROCESSO PARA PRODUZIR UM ANTICORPO HUMANIZADO DO RECEPTOR ANTI-IGF-1, E, COMPOSIÇÃO FARMACÊUTICA. São providos: um anticorpo humanizado do receptor anti-IGF-1 que inclui CDRs de uma cadeia leve e uma cadeia pesada derivadas de anticorpo parental de camundongo IGF11-16, e respectivas FRs de uma cadeia leve e uma cadeia pesada derivadas de um anticorpo humano, e em que pelo menos uma das CDRs inclui pelo menos uma substituição de resíduo de aminoácido em relação a uma CDR correspondente do anticorpo parental de camundongo; um fragmento do anticorpo humanizado do receptor anti-IGF-1; ou um derivado deste.
BR112022022030A 2020-06-02 2021-06-01 Anticorpo humanizado do receptor anti-igf-1, molécula de ácido nucleico, vetor de clonagem ou vetor de expressão, célula recombinante, processo para produzir um anticorpo humanizado do receptor anti-igf-1, e, composição farmacêutica BR112022022030A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020096344 2020-06-02
PCT/JP2021/020890 WO2021246413A1 (ja) 2020-06-02 2021-06-01 抗igf-1受容体ヒト化抗体

Publications (1)

Publication Number Publication Date
BR112022022030A2 true BR112022022030A2 (pt) 2023-01-17

Family

ID=78831168

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022030A BR112022022030A2 (pt) 2020-06-02 2021-06-01 Anticorpo humanizado do receptor anti-igf-1, molécula de ácido nucleico, vetor de clonagem ou vetor de expressão, célula recombinante, processo para produzir um anticorpo humanizado do receptor anti-igf-1, e, composição farmacêutica

Country Status (14)

Country Link
EP (1) EP4159860A1 (pt)
JP (2) JPWO2021246413A1 (pt)
KR (1) KR20230006006A (pt)
CN (1) CN115605594A (pt)
AR (1) AR122499A1 (pt)
AU (1) AU2021282629A1 (pt)
BR (1) BR112022022030A2 (pt)
CA (1) CA3176119A1 (pt)
CL (1) CL2022003399A1 (pt)
CO (1) CO2022017026A2 (pt)
IL (1) IL296519A (pt)
MX (1) MX2022015133A (pt)
TW (1) TW202210513A (pt)
WO (1) WO2021246413A1 (pt)

Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
CN114561337B (zh) * 2022-03-09 2023-10-03 广州源井生物科技有限公司 一种提高HepG2细胞克隆形成率的单克隆增强培养基和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013163633A1 (en) * 2012-04-27 2013-10-31 Millennium Pharmaceuticals, Inc. Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy
JOP20180014A1 (ar) * 2017-02-27 2019-01-30 Teijin Pharma Ltd جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه
KR20190138672A (ko) 2017-05-30 2019-12-13 데이진 화-마 가부시키가이샤 항 igf-i 수용체 항체
WO2019148410A1 (en) * 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1 antibodies
KR20200141986A (ko) * 2018-02-12 2020-12-21 다이어비티스-프리, 인크. 개선된 길항성 항-인간 cd40 단클론 항체
GB201803892D0 (en) * 2018-03-12 2018-04-25 Ultrahuman Six Ltd C-met binding agents
BR112021010479A2 (pt) * 2018-12-03 2021-11-16 Teijin Pharma Ltd Anticorpo humanizado anti-receptor de igf-i ou fragmento ou derivado do mesmo, molécula de ácido nucleico, vetor de clonagem ou vetor de expressão, célula recombinante, processo para produção de um anticorpo humanizado anti-receptor de igf-i ou fragmento ou derivado do mesmo, e, composição farmacêutica

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Publication number Publication date
WO2021246413A1 (ja) 2021-12-09
JP2024054410A (ja) 2024-04-16
CA3176119A1 (en) 2021-12-09
CL2022003399A1 (es) 2023-08-11
IL296519A (en) 2022-11-01
JPWO2021246413A1 (pt) 2021-12-09
CO2022017026A2 (es) 2022-12-09
EP4159860A1 (en) 2023-04-05
AU2021282629A1 (en) 2022-12-01
MX2022015133A (es) 2023-01-11
TW202210513A (zh) 2022-03-16
AR122499A1 (es) 2022-09-14
KR20230006006A (ko) 2023-01-10
CN115605594A (zh) 2023-01-13

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