BR112022021462A2 - Moléculas bifuncionais e métodos de sua utilização - Google Patents
Moléculas bifuncionais e métodos de sua utilizaçãoInfo
- Publication number
- BR112022021462A2 BR112022021462A2 BR112022021462A BR112022021462A BR112022021462A2 BR 112022021462 A2 BR112022021462 A2 BR 112022021462A2 BR 112022021462 A BR112022021462 A BR 112022021462A BR 112022021462 A BR112022021462 A BR 112022021462A BR 112022021462 A2 BR112022021462 A2 BR 112022021462A2
- Authority
- BR
- Brazil
- Prior art keywords
- bifunctional molecules
- methods
- domain
- specifically binds
- target
- Prior art date
Links
- 230000001588 bifunctional effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229920002477 rna polymer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
MOLÉCULAS BIFUNCIONAIS E MÉTODOS DE SUA UTILIZAÇÃO. A presente revelação se relaciona, de modo geral, às composições de moléculas bifuncionais sintéticas que compreendem um primeiro domínio que se liga especificamente a um ácido ribonucleico-alvo e um segundo domínio que se liga especificamente a um polipeptídeo-alvo, e usos destas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063013462P | 2020-04-21 | 2020-04-21 | |
US202163139916P | 2021-01-21 | 2021-01-21 | |
PCT/US2021/028499 WO2021216786A1 (en) | 2020-04-21 | 2021-04-21 | Bifunctional molecules and methods of using thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022021462A2 true BR112022021462A2 (pt) | 2023-01-17 |
Family
ID=78269946
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022021462A BR112022021462A2 (pt) | 2020-04-21 | 2021-04-21 | Moléculas bifuncionais e métodos de sua utilização |
BR112022021469A BR112022021469A2 (pt) | 2020-04-21 | 2021-04-21 | Moléculas bifuncionais e métodos de uso das mesmas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022021469A BR112022021469A2 (pt) | 2020-04-21 | 2021-04-21 | Moléculas bifuncionais e métodos de uso das mesmas |
Country Status (10)
Country | Link |
---|---|
US (2) | US20230167450A1 (pt) |
EP (2) | EP4138857A4 (pt) |
JP (2) | JP2023522961A (pt) |
KR (2) | KR20230012508A (pt) |
CN (2) | CN115916262A (pt) |
AU (2) | AU2021260934A1 (pt) |
BR (2) | BR112022021462A2 (pt) |
CA (2) | CA3176196A1 (pt) |
IL (2) | IL297483A (pt) |
WO (2) | WO2021216786A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230175038A1 (en) * | 2021-12-08 | 2023-06-08 | Janssen Pharmaceutica Nv | Crystal structure of btk protein and binding pockets thereof |
CN117159546B (zh) * | 2023-08-15 | 2024-05-10 | 华南农业大学 | 石蒜碱在制备抗狂犬病的药物中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0219143D0 (en) * | 2002-08-16 | 2002-09-25 | Univ Leicester | Modified tailed oligonucleotides |
NZ545134A (en) * | 2003-09-18 | 2009-06-26 | Lilly Co Eli | Modulation of eIF4E expression |
WO2013012752A2 (en) * | 2011-07-15 | 2013-01-24 | Sarepta Therapeutics, Inc. | Methods and compositions for manipulating translation of protein isoforms from alternative initiation start sites |
PL2920304T3 (pl) * | 2012-11-15 | 2019-07-31 | Roche Innovation Center Copenhagen A/S | Koniugaty oligonukleotydowe |
US20160194368A1 (en) * | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
US20180085391A1 (en) * | 2014-08-08 | 2018-03-29 | Modernatx, Inc. | Compositions and methods for the treatment of ophthalmic diseases and conditions |
JP7016323B2 (ja) * | 2016-06-01 | 2022-02-21 | ブリストル-マイヤーズ スクイブ カンパニー | Pd-l1結合ポリペプチドを用いるpet造影 |
WO2018213791A1 (en) * | 2017-05-18 | 2018-11-22 | Children's National Medical Center | Compositions comprising aptamers and nucleic acid payloads and methods of using the same |
EP3781670A4 (en) * | 2018-04-20 | 2021-11-10 | The Regents of the University of California | FUSION PROTEINS AND RIBONUCLEIC ACIDS FOR TRACKING AND MANIPULATION OF CELLULAR RNA |
-
2021
- 2021-04-21 BR BR112022021462A patent/BR112022021462A2/pt not_active Application Discontinuation
- 2021-04-21 AU AU2021260934A patent/AU2021260934A1/en active Pending
- 2021-04-21 AU AU2021258193A patent/AU2021258193A1/en active Pending
- 2021-04-21 EP EP21793052.8A patent/EP4138857A4/en active Pending
- 2021-04-21 CN CN202180044055.0A patent/CN115916262A/zh not_active Withdrawn
- 2021-04-21 KR KR1020227040517A patent/KR20230012508A/ko unknown
- 2021-04-21 BR BR112022021469A patent/BR112022021469A2/pt not_active Application Discontinuation
- 2021-04-21 CA CA3176196A patent/CA3176196A1/en active Pending
- 2021-04-21 US US17/920,752 patent/US20230167450A1/en active Pending
- 2021-04-21 US US17/920,769 patent/US20230158156A1/en active Pending
- 2021-04-21 EP EP21793054.4A patent/EP4138858A1/en active Pending
- 2021-04-21 WO PCT/US2021/028499 patent/WO2021216786A1/en unknown
- 2021-04-21 CA CA3176210A patent/CA3176210A1/en active Pending
- 2021-04-21 JP JP2022564146A patent/JP2023522961A/ja active Pending
- 2021-04-21 JP JP2022564133A patent/JP2023522957A/ja active Pending
- 2021-04-21 WO PCT/US2021/028498 patent/WO2021216785A1/en unknown
- 2021-04-21 KR KR1020227040524A patent/KR20230014695A/ko unknown
- 2021-04-21 CN CN202180044038.7A patent/CN115916219A/zh not_active Withdrawn
-
2022
- 2022-10-20 IL IL297483A patent/IL297483A/en unknown
- 2022-10-20 IL IL297482A patent/IL297482A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112022021469A2 (pt) | 2023-04-04 |
KR20230014695A (ko) | 2023-01-30 |
IL297482A (en) | 2022-12-01 |
CN115916262A (zh) | 2023-04-04 |
JP2023522961A (ja) | 2023-06-01 |
KR20230012508A (ko) | 2023-01-26 |
WO2021216786A1 (en) | 2021-10-28 |
EP4138857A1 (en) | 2023-03-01 |
AU2021258193A1 (en) | 2022-11-24 |
EP4138857A4 (en) | 2024-05-15 |
IL297483A (en) | 2022-12-01 |
AU2021260934A1 (en) | 2022-11-24 |
EP4138858A1 (en) | 2023-03-01 |
US20230167450A1 (en) | 2023-06-01 |
US20230158156A1 (en) | 2023-05-25 |
CA3176196A1 (en) | 2021-10-28 |
CN115916219A (zh) | 2023-04-04 |
CA3176210A1 (en) | 2021-10-28 |
JP2023522957A (ja) | 2023-06-01 |
WO2021216785A1 (en) | 2021-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing |