BR112022017060A2 - Aplicação de dissulfiram na resistência ao coronavírus - Google Patents
Aplicação de dissulfiram na resistência ao coronavírusInfo
- Publication number
- BR112022017060A2 BR112022017060A2 BR112022017060A BR112022017060A BR112022017060A2 BR 112022017060 A2 BR112022017060 A2 BR 112022017060A2 BR 112022017060 A BR112022017060 A BR 112022017060A BR 112022017060 A BR112022017060 A BR 112022017060A BR 112022017060 A2 BR112022017060 A2 BR 112022017060A2
- Authority
- BR
- Brazil
- Prior art keywords
- disulfiram
- coronavirus
- application
- resistance
- coronavirus resistance
- Prior art date
Links
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 title abstract 10
- 241000711573 Coronaviridae Species 0.000 title abstract 6
- 229960002563 disulfiram Drugs 0.000 title abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
APLICAÇÃO DE DISSULFIRAM NA RESISTÊNCIA AO CORONAVÍRUS. Uma aplicação de dissulfiram na resistência ao coronavírus. Uma aplicação de dissulfiram na preparação de fármacos para tratamento e/ou prevenção de doenças causadas por coronavírus. Por meio de experimentos de atividade enzimática in vitro, verificou-se que o dissulfiram pode inibir bem a atividade da principal protease em coronavírus, preenchendo a falta da técnica anterior para tratar doenças causadas por coronavírus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010121688 | 2020-02-26 | ||
PCT/CN2021/078185 WO2021170093A1 (zh) | 2020-02-26 | 2021-02-26 | 双硫仑在抗冠状病毒中的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022017060A2 true BR112022017060A2 (pt) | 2022-11-16 |
Family
ID=77370947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022017060A BR112022017060A2 (pt) | 2020-02-26 | 2021-02-26 | Aplicação de dissulfiram na resistência ao coronavírus |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230293457A1 (pt) |
EP (1) | EP4115880A4 (pt) |
JP (1) | JP2023515227A (pt) |
KR (1) | KR20220146558A (pt) |
CN (13) | CN115645393A (pt) |
BR (1) | BR112022017060A2 (pt) |
WO (1) | WO2021170093A1 (pt) |
Families Citing this family (5)
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TW202207909A (zh) * | 2020-06-16 | 2022-03-01 | 中國醫藥大學 | 二硫龍治療SARS-CoV-2感染的用途 |
CN113648293B (zh) * | 2021-08-19 | 2022-07-05 | 山东达因海洋生物制药股份有限公司 | 对苯醌和/或对苯醌衍生物在制备抗新型冠状病毒药物中的应用 |
CN114668751A (zh) * | 2022-03-22 | 2022-06-28 | 天津国际生物医药联合研究院 | 双硫仑在抗人冠状病毒nl63感染中的应用 |
CN115089564A (zh) * | 2022-05-18 | 2022-09-23 | 南方科技大学 | 紫草素和左旋紫草素在制备抗冠状病毒药物中的应用 |
CN115025165A (zh) * | 2022-06-09 | 2022-09-09 | 南京农业大学 | 莓茶提取物在制备抗猪流行性腹泻病毒的药物中的应用 |
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2021
- 2021-02-26 CN CN202211106171.3A patent/CN115645393A/zh active Pending
- 2021-02-26 CN CN202180016668.3A patent/CN115175673A/zh active Pending
- 2021-02-26 BR BR112022017060A patent/BR112022017060A2/pt unknown
- 2021-02-26 CN CN202211106165.8A patent/CN115569196B/zh active Active
- 2021-02-26 CN CN202211104686.XA patent/CN115645396A/zh active Pending
- 2021-02-26 JP JP2022551788A patent/JP2023515227A/ja active Pending
- 2021-02-26 EP EP21760398.4A patent/EP4115880A4/en active Pending
- 2021-02-26 CN CN202211107010.6A patent/CN115252610B/zh active Active
- 2021-02-26 KR KR1020227033090A patent/KR20220146558A/ko unknown
- 2021-02-26 CN CN202211105155.2A patent/CN115569135A/zh active Pending
- 2021-02-26 WO PCT/CN2021/078185 patent/WO2021170093A1/zh unknown
- 2021-02-26 CN CN202211104682.1A patent/CN115778943B/zh active Active
- 2021-02-26 CN CN202211105198.0A patent/CN115569133B/zh active Active
- 2021-02-26 CN CN202211104684.0A patent/CN115581692B/zh active Active
- 2021-02-26 CN CN202110219570.XA patent/CN113304131B/zh active Active
- 2021-02-26 CN CN202211105196.1A patent/CN115671119B/zh active Active
- 2021-02-26 US US17/801,689 patent/US20230293457A1/en active Pending
- 2021-02-26 CN CN202211104669.6A patent/CN115770246B/zh active Active
- 2021-02-26 CN CN202211105211.2A patent/CN115998718B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN115998718B (zh) | 2023-12-12 |
CN115175673A (zh) | 2022-10-11 |
CN113304131A (zh) | 2021-08-27 |
CN115645396A (zh) | 2023-01-31 |
CN115569133A (zh) | 2023-01-06 |
CN115581692B (zh) | 2023-10-17 |
CN115569196A (zh) | 2023-01-06 |
CN115581692A (zh) | 2023-01-10 |
CN115770246B (zh) | 2024-01-23 |
EP4115880A1 (en) | 2023-01-11 |
US20230293457A1 (en) | 2023-09-21 |
CN115778943A (zh) | 2023-03-14 |
CN115252610B (zh) | 2024-03-26 |
CN115998718A (zh) | 2023-04-25 |
CN115671119B (zh) | 2023-11-10 |
JP2023515227A (ja) | 2023-04-12 |
CN115645393A (zh) | 2023-01-31 |
CN115569135A (zh) | 2023-01-06 |
CN115770246A (zh) | 2023-03-10 |
CN113304131B (zh) | 2022-10-18 |
CN115671119A (zh) | 2023-02-03 |
CN115569133B (zh) | 2024-04-26 |
EP4115880A4 (en) | 2024-04-10 |
WO2021170093A1 (zh) | 2021-09-02 |
CN115778943B (zh) | 2023-11-10 |
KR20220146558A (ko) | 2022-11-01 |
CN115569196B (zh) | 2024-06-18 |
CN115252610A (zh) | 2022-11-01 |
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