BR112022011810A2 - Compostos inibidores de oga - Google Patents
Compostos inibidores de ogaInfo
- Publication number
- BR112022011810A2 BR112022011810A2 BR112022011810A BR112022011810A BR112022011810A2 BR 112022011810 A2 BR112022011810 A2 BR 112022011810A2 BR 112022011810 A BR112022011810 A BR 112022011810A BR 112022011810 A BR112022011810 A BR 112022011810A BR 112022011810 A2 BR112022011810 A2 BR 112022011810A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- oga
- compositions
- inhibitor compounds
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPOSTOS INIBIDORES DE OGA. A presente invenção refere-se a inibidores de O-GlcNAc hidrolase (OGA). A invenção também se refere a composições farmacêuticas compreendendo tais compostos, a processos para preparar tais compostos e composições e ao uso de tais compostos e composições para a prevenção e tratamento de distúrbios nos quais a inibição de OGA é benéfica, tais como tauopatias, em particular, doença de Alzheimer ou paralisia supranuclear progressiva; e doenças neurodegenerativas acompanhadas por uma patologia de tau, em particular, esclerose lateral amiotrófica ou demência do lobo frontotemporal causada por mutações C9ORF72.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19383138 | 2019-12-18 | ||
EP20197523 | 2020-09-22 | ||
EP20203022 | 2020-10-21 | ||
PCT/EP2020/087201 WO2021123294A1 (en) | 2019-12-18 | 2020-12-18 | Oga inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022011810A2 true BR112022011810A2 (pt) | 2022-08-30 |
Family
ID=74130209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022011810A BR112022011810A2 (pt) | 2019-12-18 | 2020-12-18 | Compostos inibidores de oga |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230099293A1 (pt) |
EP (1) | EP4077323A1 (pt) |
JP (1) | JP2023507184A (pt) |
KR (1) | KR20220118483A (pt) |
CN (1) | CN114867725A (pt) |
AU (1) | AU2020409728A1 (pt) |
BR (1) | BR112022011810A2 (pt) |
CA (1) | CA3160405A1 (pt) |
IL (1) | IL293931A (pt) |
MX (1) | MX2022007654A (pt) |
WO (1) | WO2021123294A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202346267A (zh) | 2022-03-07 | 2023-12-01 | 美商安進公司 | 用於製備4-甲基-2-丙-2-基-吡啶-3-甲腈之方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2174746A1 (en) * | 1972-03-09 | 1973-10-19 | Anvar | 1-methyl-4-anlino-5-aza indoles - antiinflammatories |
GB201103526D0 (en) | 2011-03-02 | 2011-04-13 | Summit Corp Plc | Selective glycosidase inhibitors and uses thereof |
ES2723883T3 (es) | 2013-03-14 | 2019-09-03 | Merck Patent Gmbh | Inhibidores de glicosidasa |
EP2818472A1 (en) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators |
EP3186243B1 (en) | 2014-08-28 | 2021-07-21 | Asceneuron SA | Glycosidase inhibitors |
WO2017106254A1 (en) | 2015-12-18 | 2017-06-22 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
DE102015122932A1 (de) | 2015-12-29 | 2017-06-29 | fos4X GmbH | Verfahren zum Prognostizieren der Anlagerung von Eis an einem Rotorblatt einer Windkraftanlage und dessen Verwendung |
WO2017144637A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Acid addition salts of piperazine derivatives |
US11612599B2 (en) | 2016-02-25 | 2023-03-28 | Asceneuron Sa | Glycosidase inhibitors |
CN110312716A (zh) * | 2016-12-16 | 2019-10-08 | 詹森药业有限公司 | 双环oga抑制剂化合物 |
TWI654978B (zh) | 2017-01-27 | 2019-04-01 | 美商美國禮來大藥廠 | 5-甲基-1,2,4-二唑-3-基化合物 |
TWI669302B (zh) | 2017-05-25 | 2019-08-21 | 美商美國禮來大藥廠 | 5-甲基-1,3,4-<img align="absmiddle" height="18px" width="27px" file="d10999.TIF" alt="其他非圖式 ed10999.png" img-content="tif" orientation="portrait" inline="yes" giffile="ed10999.png"></img>二唑-2-基化合物 |
CA3093315A1 (en) | 2018-03-14 | 2019-09-19 | Biogen Ma Inc. | O-glycoprotein-2-acetamido-2-deoxy-3-d-glycopyranosidase inhibitors |
-
2020
- 2020-12-18 CN CN202080087697.4A patent/CN114867725A/zh active Pending
- 2020-12-18 WO PCT/EP2020/087201 patent/WO2021123294A1/en unknown
- 2020-12-18 EP EP20838041.0A patent/EP4077323A1/en active Pending
- 2020-12-18 MX MX2022007654A patent/MX2022007654A/es unknown
- 2020-12-18 KR KR1020227024322A patent/KR20220118483A/ko active Search and Examination
- 2020-12-18 US US17/757,623 patent/US20230099293A1/en active Pending
- 2020-12-18 AU AU2020409728A patent/AU2020409728A1/en active Pending
- 2020-12-18 BR BR112022011810A patent/BR112022011810A2/pt unknown
- 2020-12-18 IL IL293931A patent/IL293931A/en unknown
- 2020-12-18 JP JP2022537319A patent/JP2023507184A/ja active Pending
- 2020-12-18 CA CA3160405A patent/CA3160405A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4077323A1 (en) | 2022-10-26 |
CA3160405A1 (en) | 2021-06-24 |
KR20220118483A (ko) | 2022-08-25 |
CN114867725A (zh) | 2022-08-05 |
MX2022007654A (es) | 2022-07-19 |
WO2021123294A1 (en) | 2021-06-24 |
JP2023507184A (ja) | 2023-02-21 |
US20230099293A1 (en) | 2023-03-30 |
AU2020409728A1 (en) | 2022-08-11 |
IL293931A (en) | 2022-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA53937B1 (fr) | Compositions comprenant des souches bactériennes | |
BR112013022039A2 (pt) | derivados 6,7-di-hidro-pirazol[1,5-a]pirazin-4-ilamina úteis como inibidores de beta-secretase (bace) | |
TN2017000144A1 (en) | 2-amino-6-(difluoromethyl)- 5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors | |
BR112016017344A2 (pt) | Amidas de heteroaril como inibidores de agregação de proteínas | |
JO3459B1 (ar) | تركيبات صيدلانية لعلاج مرض الزهايمر | |
SA114360153B1 (ar) | مركبات واستخدامها كمثبطات bace | |
MA39219A1 (fr) | Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique | |
TN2017000134A1 (en) | 2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors for treating alzheimer's disease | |
BR112012033291A2 (pt) | derivados de 3-amino-5,6-di-hidro-1h-piranzin-2-ona úteis para o tratamento de doença de alzheimer e outras formas de demência | |
BR112012031337A2 (pt) | derivados de 5-amino-3,6-di-hidro-1h-pirazin-2-ona úteis como inibidores de beta-secretase (bace) | |
EA201291435A1 (ru) | Производные 5,6-дигидро-2h-[1,4]оксазин-3-иламина в качестве ингибиторов бета-секретазы (bace) | |
ATE511843T1 (de) | Dihydropyridin-verbindungen für neurodegenerative erkrankungen und demenz | |
MX2012006730A (es) | Tiazolidinadionas moderadoras de receptores activados por proliferador de peroxizoma (ppar) y combinaciones para tratamiento de enfermedades neurodegenerativas y otras enfermedades metabolicas. | |
EA201190020A1 (ru) | Производные изоиндола в качестве ингибиторов васе и их применение | |
MX2014006752A (es) | Derivados de 5-(3-aminofenil)-5-alquil-5,6-dihidro-2h-[1,4]oxazin- 3-amina. | |
MX2010004319A (es) | Compuesto de alfa-(n-sulfonamido)acetamida novedoso como un inhibidor de producccion de peptido beta amiloide. | |
BR112012021656A2 (pt) | composto, uso do mesmo, e, composição farmacêutica | |
BR112021006319A2 (pt) | compostos de indolinona para uso como inibidores de map4k1 | |
MX2017008083A (es) | Compuestos 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2h-pirrol-5-amina inhibidores de beta-secretasa. | |
BR112022011810A2 (pt) | Compostos inibidores de oga | |
BR112022011812A2 (pt) | Compostos inibidores da oga | |
MX2018003565A (es) | Derivados de 2,3,4,5-tetrahidropiridin-6-amina. | |
PH12017501668A1 (en) | Bace1 inhibitors | |
MA54630B1 (fr) | N,n-bis-2-mercaptoéthyle isophtalamide pour le traitement des maladies neurodégénératives | |
EA201992188A1 (ru) | Способы и композиции для лечения ассоциированных со старением нарушений с применением ccr3-ингибиторов |