FR2174746A1 - 1-methyl-4-anlino-5-aza indoles - antiinflammatories - Google Patents
1-methyl-4-anlino-5-aza indoles - antiinflammatoriesInfo
- Publication number
- FR2174746A1 FR2174746A1 FR7208256A FR7208256A FR2174746A1 FR 2174746 A1 FR2174746 A1 FR 2174746A1 FR 7208256 A FR7208256 A FR 7208256A FR 7208256 A FR7208256 A FR 7208256A FR 2174746 A1 FR2174746 A1 FR 2174746A1
- Authority
- FR
- France
- Prior art keywords
- methyl
- antiinflammatories
- evapd
- hal
- degrees
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Abstract
Compounds of formula (I) are new: (where R1 and R2= H, lower alkyl, hydroxyalkyl, or alkoxy, halogen, CF3 or NO2) Antiinflammatories. EXAMPLE (II, hal=Cl) was prepd. by treating 1-methyl-4,5-dihydro-4-oxo-5-aza indole with POCl3 and treating the base with HCl. 20.3 g. (II; hal=Cl)HCl salt, were dissolved in 150 ml. ethylene glycol monomethyl ether and treated with 40.3 g. (III, R1= m-CF3, R2=H). The mixt. was refluxed for 4-5 hrs. The solvent was evapd. in vacuo on a steam bath, and the residue suspended in 120 ml. 10% NaOH. The product was extracted into chloroform, washed, dried and evapd., finishing with prolonged heating at 100 degrees C/10-15mm, to eliminate excess (III). The residue was recrystallised from cyclohexane/benzene (3:1) to give 21.8 g. 1-methyl-4(3-trifluoromethylanilino)-5-azaindole m.pt. 119-120 degrees C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7208256A FR2174746A1 (en) | 1972-03-09 | 1972-03-09 | 1-methyl-4-anlino-5-aza indoles - antiinflammatories |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7208256A FR2174746A1 (en) | 1972-03-09 | 1972-03-09 | 1-methyl-4-anlino-5-aza indoles - antiinflammatories |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2174746A1 true FR2174746A1 (en) | 1973-10-19 |
FR2174746B1 FR2174746B1 (en) | 1975-04-25 |
Family
ID=9094930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7208256A Granted FR2174746A1 (en) | 1972-03-09 | 1972-03-09 | 1-methyl-4-anlino-5-aza indoles - antiinflammatories |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2174746A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021123294A1 (en) * | 2019-12-18 | 2021-06-24 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
-
1972
- 1972-03-09 FR FR7208256A patent/FR2174746A1/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021123294A1 (en) * | 2019-12-18 | 2021-06-24 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
Also Published As
Publication number | Publication date |
---|---|
FR2174746B1 (en) | 1975-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |