BR112022011177A2 - Domínios de repetição de anquirina projetados com resíduos de superfície alterados - Google Patents

Domínios de repetição de anquirina projetados com resíduos de superfície alterados

Info

Publication number
BR112022011177A2
BR112022011177A2 BR112022011177A BR112022011177A BR112022011177A2 BR 112022011177 A2 BR112022011177 A2 BR 112022011177A2 BR 112022011177 A BR112022011177 A BR 112022011177A BR 112022011177 A BR112022011177 A BR 112022011177A BR 112022011177 A2 BR112022011177 A2 BR 112022011177A2
Authority
BR
Brazil
Prior art keywords
proteins
anchyrin
surface residues
altered surface
repetition
Prior art date
Application number
BR112022011177A
Other languages
English (en)
Portuguese (pt)
Inventor
Binz Kaspar
Schilling Johannes
Forrer Patrik
Original Assignee
Molecular Partners Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Partners Ag filed Critical Molecular Partners Ag
Publication of BR112022011177A2 publication Critical patent/BR112022011177A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112022011177A 2019-12-11 2020-12-11 Domínios de repetição de anquirina projetados com resíduos de superfície alterados BR112022011177A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP19215433 2019-12-11
EP19215434 2019-12-11
EP19215436 2019-12-11
EP19215435 2019-12-11
EP20161059 2020-03-04
EP20181234 2020-06-19
PCT/EP2020/085855 WO2021116462A1 (fr) 2019-12-11 2020-12-11 Domaines de répétition d'ankyrine conçus avec des résidus de surface modifiés

Publications (1)

Publication Number Publication Date
BR112022011177A2 true BR112022011177A2 (pt) 2022-09-27

Family

ID=73790118

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112022011177A BR112022011177A2 (pt) 2019-12-11 2020-12-11 Domínios de repetição de anquirina projetados com resíduos de superfície alterados
BR112022011456A BR112022011456A2 (pt) 2019-12-11 2020-12-11 Proteínas recombinantes de ligação a complexo de peptídeo-mhc e geração e uso das mesmas

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112022011456A BR112022011456A2 (pt) 2019-12-11 2020-12-11 Proteínas recombinantes de ligação a complexo de peptídeo-mhc e geração e uso das mesmas

Country Status (11)

Country Link
US (4) US20220106707A1 (fr)
EP (2) EP4073092A2 (fr)
JP (2) JP2023506765A (fr)
KR (2) KR20220113492A (fr)
CN (2) CN114929730A (fr)
AU (2) AU2020399230A1 (fr)
BR (2) BR112022011177A2 (fr)
CA (2) CA3161326A1 (fr)
IL (2) IL293698A (fr)
MX (2) MX2022007120A (fr)
WO (2) WO2021116469A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022007120A (es) 2019-12-11 2022-09-09 Molecular Partners Ag Proteínas de unión al complejo péptido-mhc recombinantes y su generación y uso.
JP2023525518A (ja) 2020-05-06 2023-06-16 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規アンキリンリピート結合タンパク質とその用途
EP3957649A1 (fr) * 2020-08-18 2022-02-23 Athebio AG Modules de coiffage de domaines de répétition d'ankyrine à n-terminaux améliorés
US11981710B2 (en) 2020-08-18 2024-05-14 Athebio Ag N-terminal capping modules of ankyrin repeat domains
EP4304731A1 (fr) 2021-03-09 2024-01-17 Molecular Partners AG Nouveaux agents de mise en contact de lymphocytes t multi-spécifiques à base de darpin
EP4137508A1 (fr) * 2021-08-17 2023-02-22 Athebio AG Variantes de domaines de répétition d'ankyrine
WO2023021050A1 (fr) * 2021-08-17 2023-02-23 Athebio Ag Variants de domaines de répétition d'ankyrine
AU2022413461A1 (en) 2021-12-14 2024-06-06 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
CA3240046A1 (fr) * 2021-12-14 2023-06-22 Cdr-Life Ag Activateur double de lymphocytes t ciblant le cmh
WO2024028278A1 (fr) 2022-08-01 2024-02-08 Molecular Partners Ag Domaines de répétition conçus à charges modifiées et leur utilisation

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804381A (en) 1996-10-03 1998-09-08 Cornell Research Foundation Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof
CA2421447C (fr) 2000-09-08 2012-05-08 Universitat Zurich Groupes de proteines a domaines de repetition comprenant des modules de repetition
WO2003070752A2 (fr) 2002-02-20 2003-08-28 Dyax Corporation Ligands de liaison au complexe mhc-peptide
CN101056646A (zh) 2004-11-12 2007-10-17 拜耳先灵医药股份有限公司 重组新城疫病毒
DK1902131T3 (da) 2005-07-08 2010-03-01 Univ Zuerich Fag-display under anvendelse af cotranslational translokation af fusionspolypeptider
EP2565204B1 (fr) 2007-07-27 2015-10-07 immatics biotechnologies GmbH Nouveaux épitopes immunogènes pour l'immunothérapie
US9365629B2 (en) 2007-09-24 2016-06-14 University Of Zurich Designed armadillo repeat proteins
NZ592591A (en) 2008-11-03 2012-04-27 Molecular Partners Ag Binding proteins comprising ankyrin repeast domains that inhibit the vegf-a receptor interaction
AR081361A1 (es) 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
JP6173216B2 (ja) 2010-11-26 2017-08-02 モレキュラー・パートナーズ・アーゲーＭｏｌｅｃｕｌａｒ Ｐａｒｔｎｅｒｓ Ａｇ 設計アンキリンリピートタンパク質のための改善されたキャッピングモジュール
KR20140039203A (ko) * 2011-04-29 2014-04-01 얀센 바이오테크 인코포레이티드 Il4/il13 결합 반복 단백질 및 용도
CN104508129A (zh) 2012-06-28 2015-04-08 分子伴侣公司 设计的与血小板衍生生长因子结合的锚蛋白重复序列蛋白
WO2014060365A1 (fr) 2012-10-15 2014-04-24 Universität Zürich Prorektorat Mnw Ligands her2 bispécifiques pour la thérapie du cancer
EP2738180A1 (fr) * 2012-11-30 2014-06-04 Molecular Partners AG Protéines de liaison comportant au moins deux domaines de liaison ciblant HER2
JP6486908B2 (ja) 2013-05-31 2019-03-20 モレキュラー パートナーズ アクチェンゲゼルシャフト 肝細胞増殖因子に結合する設計アンキリン反復タンパク質
BR112016021004A2 (pt) 2014-03-14 2018-01-23 Immunocore Limited biblioteca de partículas; receptor de células t (tcr) isolado não natural; uso de uma biblioteca; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; ácido nucleico; método de construção de uma biblioteca de partículas; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; e partícula
US20170226158A1 (en) * 2014-08-11 2017-08-10 Medimmune Limited Intracellular antigen binding
AU2016235251B2 (en) 2015-03-23 2022-03-17 The Johns Hopkins University HLA-restricted epitopes encoded by somatically mutated genes
SG11201707606RA (en) 2015-04-02 2017-10-30 Molecular Partners Ag Designed ankyrin repeat domains with binding specificity for serum albumin
CA3025894A1 (fr) 2016-06-02 2017-12-07 Immunocore Limited Schema de traitement pour proteine de fusion scfv tcr-anti-cd3 gp100 specifique
WO2018054971A1 (fr) 2016-09-22 2018-03-29 Molecular Partners Ag Protéines de liaison recombinantes et leur utilisation
EP3710042A4 (fr) * 2017-11-16 2021-11-24 The Regents of The University of California Polypeptides chimériques contenant un domaine de clivage par capteur de force et leurs méthodes d'utilisation
JP2022535106A (ja) 2019-06-04 2022-08-04 モレキュラー パートナーズ アクチェンゲゼルシャフト 改善された安定性を有する設計されたアンキリン反復ドメイン
KR20220016942A (ko) 2019-06-04 2022-02-10 몰리큘라 파트너스 아게 재조합 fap 결합 단백질 및 이의 용도
JP2022535564A (ja) 2019-06-04 2022-08-09 モレキュラー パートナーズ アクチェンゲゼルシャフト 多選択性タンパク質
JP2022535107A (ja) 2019-06-04 2022-08-04 モレキュラー パートナーズ アクチェンゲゼルシャフト 組換え４－１ｂｂ結合タンパク質及びそれらの使用
EP4073093A2 (fr) 2019-12-11 2022-10-19 Molecular Partners AG Protéines de liaison de complexe peptide-mhc de recombinaison, leur production et leur utilisation
MX2022007120A (es) 2019-12-11 2022-09-09 Molecular Partners Ag Proteínas de unión al complejo péptido-mhc recombinantes y su generación y uso.
JP2023525518A (ja) * 2020-05-06 2023-06-16 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規アンキリンリピート結合タンパク質とその用途
KR20230022176A (ko) 2020-05-14 2023-02-14 몰리큘라 파트너스 아게 다중특이적 단백질
EP4149960A1 (fr) 2020-05-14 2023-03-22 Molecular Partners AG Protéines de liaison à cd40 recombinantes et leur utilisation

Also Published As

Publication number Publication date
US20220106707A1 (en) 2022-04-07
JP2023506765A (ja) 2023-02-20
US20230340698A1 (en) 2023-10-26
WO2021116469A2 (fr) 2021-06-17
IL293704A (en) 2022-08-01
US20230243070A1 (en) 2023-08-03
EP4073092A2 (fr) 2022-10-19
US20220064234A1 (en) 2022-03-03
AU2020402581A9 (en) 2022-07-14
IL293698A (en) 2022-08-01
CN115003689A (zh) 2022-09-02
CN114929730A (zh) 2022-08-19
US11578427B2 (en) 2023-02-14
KR20220113492A (ko) 2022-08-12
CA3161321A1 (fr) 2021-06-17
AU2020399230A1 (en) 2022-06-23
CA3161326A1 (fr) 2021-06-17
WO2021116462A1 (fr) 2021-06-17
JP2023506757A (ja) 2023-02-20
WO2021116469A3 (fr) 2021-12-02
BR112022011456A2 (pt) 2022-08-23
AU2020402581A1 (en) 2022-06-23
KR20220113491A (ko) 2022-08-12
MX2022007120A (es) 2022-09-09
MX2022007122A (es) 2022-09-09
EP4073091A1 (fr) 2022-10-19

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]