BR112022010435A2 - Camada-suporte solúvel para filme fino oral (otf) - Google Patents
Camada-suporte solúvel para filme fino oral (otf)Info
- Publication number
- BR112022010435A2 BR112022010435A2 BR112022010435A BR112022010435A BR112022010435A2 BR 112022010435 A2 BR112022010435 A2 BR 112022010435A2 BR 112022010435 A BR112022010435 A BR 112022010435A BR 112022010435 A BR112022010435 A BR 112022010435A BR 112022010435 A2 BR112022010435 A2 BR 112022010435A2
- Authority
- BR
- Brazil
- Prior art keywords
- thin film
- otf
- oral thin
- support layer
- soluble support
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Abstract
CAMADA-SUPORTE SOLÚVEL PARA FILME FINO ORAL (OTF). A presente invenção refere-se a um filme fino oral de múltiplas camadas compreendendo uma camada-matriz, que contém pelo menos um polímero e pelo menos um agente farmaceuticamente ativo, e pelo menos uma camada-suporte, em que a pelo menos uma camada-suporte compreende pelo menos um polímero contendo grupos carboxila livres, em que 10 a 100% dos grupos carboxila livres do pelo menos um polímero compreendendo grupos carboxila livres estão presentes em uma forma neutralizada como um sal. A invenção refere-se também a um método para a sua produção e a seu uso como medicamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102019135432.3A DE102019135432A1 (de) | 2019-12-20 | 2019-12-20 | Lösliche Rückschicht für OTF |
| PCT/EP2020/087195 WO2021123289A1 (de) | 2019-12-20 | 2020-12-18 | Lösliche rückschicht für otf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022010435A2 true BR112022010435A2 (pt) | 2022-09-06 |
Family
ID=74191682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022010435A BR112022010435A2 (pt) | 2019-12-20 | 2020-12-18 | Camada-suporte solúvel para filme fino oral (otf) |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230033638A1 (pt) |
| EP (1) | EP4076392A1 (pt) |
| JP (1) | JP2023508293A (pt) |
| CN (1) | CN114845700A (pt) |
| BR (1) | BR112022010435A2 (pt) |
| CA (1) | CA3165394A1 (pt) |
| DE (1) | DE102019135432A1 (pt) |
| WO (1) | WO2021123289A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102021107829A1 (de) * | 2021-03-29 | 2022-09-29 | Lts Lohmann Therapie-Systeme Ag. | Oraler Dünnfilm |
| DE102021130950A1 (de) * | 2021-11-25 | 2023-05-25 | Lts Lohmann Therapie-Systeme Ag. | Applikationshilfe |
| DE102021130954A1 (de) * | 2021-11-25 | 2023-05-25 | Lts Lohmann Therapie-Systeme Ag. | Orales Micronadel Patch |
| DE102022125993A1 (de) | 2022-10-07 | 2024-04-18 | Codonis Ag | Oraler Applikator, Verfahren zu dessen Regeneration und Verwendung eines Aufsatzes zu dessen Bereitstellung |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7276246B2 (en) * | 2003-05-09 | 2007-10-02 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
| DE10328942A1 (de) * | 2003-06-27 | 2005-01-27 | Lts Lohmann Therapie-Systeme Ag | Transmukosale Darreichungsformen mit verminderter Schleimhautirritation |
| DE102005007059A1 (de) * | 2005-02-15 | 2006-08-24 | Röhm GmbH & Co. KG | Teilneutralisiertes anionisches (Meth)acrylat-Copolymer |
| WO2007096906A2 (en) * | 2006-02-27 | 2007-08-30 | Panacea Biotec Ltd. | Novel buccoadhesive compositions and process of preparation thereof |
| EP2889030A1 (en) * | 2013-12-30 | 2015-07-01 | Uluru Inc. | Controlling the erosion rates of mucoadhesive devices that deliver actives and other compounds and providing increased and variable therapeutic blood levels |
| US11207316B2 (en) * | 2014-05-30 | 2021-12-28 | West Virginia University | Ketamine or dextromethorphan formulations and methods of use |
| CN104546806A (zh) * | 2015-01-05 | 2015-04-29 | 万特制药(海南)有限公司 | 一种含有利培酮的口腔速溶膜及其制备方法 |
| JP2020526579A (ja) * | 2017-06-29 | 2020-08-31 | スカイライン バイオサイエンシズ，エルエルシー | イソトレチノイン口腔粘膜製剤及びその使用方法 |
| DE102017129012A1 (de) * | 2017-12-06 | 2019-06-06 | Lts Lohmann Therapie-Systeme Ag | Oraler Dünnfilm mit hoher Wirkstoffbeladung |
| DE102018109981A1 (de) * | 2018-04-25 | 2019-10-31 | Lts Lohmann Therapie-Systeme Ag | U-förmiger oraler Dünnfilm |
-
2019
- 2019-12-20 DE DE102019135432.3A patent/DE102019135432A1/de active Pending
-
2020
- 2020-12-18 CN CN202080088135.1A patent/CN114845700A/zh active Pending
- 2020-12-18 EP EP20842699.9A patent/EP4076392A1/de active Pending
- 2020-12-18 WO PCT/EP2020/087195 patent/WO2021123289A1/de unknown
- 2020-12-18 BR BR112022010435A patent/BR112022010435A2/pt unknown
- 2020-12-18 CA CA3165394A patent/CA3165394A1/en active Pending
- 2020-12-18 JP JP2022537418A patent/JP2023508293A/ja active Pending
- 2020-12-18 US US17/787,874 patent/US20230033638A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN114845700A (zh) | 2022-08-02 |
| CA3165394A1 (en) | 2021-06-24 |
| WO2021123289A1 (de) | 2021-06-24 |
| DE102019135432A1 (de) | 2021-06-24 |
| EP4076392A1 (de) | 2022-10-26 |
| US20230033638A1 (en) | 2023-02-02 |
| JP2023508293A (ja) | 2023-03-02 |
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