BR112022006743A2 - Composições e métodos in vitro para potencializar a ativação de células dendríticas e células t e para induzir uma resposta imunológica de th-1 - Google Patents

Composições e métodos in vitro para potencializar a ativação de células dendríticas e células t e para induzir uma resposta imunológica de th-1

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Publication number
BR112022006743A2
BR112022006743A2 BR112022006743A BR112022006743A BR112022006743A2 BR 112022006743 A2 BR112022006743 A2 BR 112022006743A2 BR 112022006743 A BR112022006743 A BR 112022006743A BR 112022006743 A BR112022006743 A BR 112022006743A BR 112022006743 A2 BR112022006743 A2 BR 112022006743A2
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Brazil
Prior art keywords
cells
activation
vitro
methods
dendritic cells
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BR112022006743A
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English (en)
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Leo BOSCH Marnix
F Powers Linda
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Northwest Biotherapeutics Inc
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Publication of BR112022006743A2 publication Critical patent/BR112022006743A2/pt

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Abstract

COMPOSIÇÕES E MÉTODOS IN VITRO PARA POTENCIALIZAR A ATIVAÇÃO DE CÉLULAS DENDRÍTICAS E CÉLULAS T E PARA INDUZIR UMA RESPOSTA IMUNOLÓGICA DE TH-1. A presente revelação fornece composições e métodos in vitro ou ex vivo para obter uma resposta imunológica de Th1 específica de antígeno potencializada. As composições podem compreender células dendríticas potencializadas por ativação ou células T produzidas in vitro. Os métodos compreendem contactar células dendríticas imaturas com um agente de maturação que compreende um agente de maturação de células dendríticas, interferon y e um lipídeo ativador de inflamação que pode produzir células dendríticas hiperativadas. O método pode compreender adicionalmente contactar as células dendríticas em maturação com um antígeno predeterminado durante a maturação. Um método in vitro ou ex vivo também é fornecido em que as células dendríticas hiperativas podem ser usadas para induzir a ativação de células T naïve, em que as células T ativadas podem ser formuladas para administração a um indivíduo que necessite de tal tratamento.
BR112022006743A 2019-10-07 2020-10-07 Composições e métodos in vitro para potencializar a ativação de células dendríticas e células t e para induzir uma resposta imunológica de th-1 BR112022006743A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962912005P 2019-10-07 2019-10-07
PCT/US2020/054621 WO2021071977A1 (en) 2019-10-07 2020-10-07 In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response

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BR112022006743A2 true BR112022006743A2 (pt) 2022-08-30

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US (1) US20240122975A1 (pt)
EP (1) EP4041298A4 (pt)
JP (1) JP2022552200A (pt)
KR (1) KR20220098351A (pt)
CN (1) CN115461073A (pt)
AU (1) AU2020363707A1 (pt)
BR (1) BR112022006743A2 (pt)
CA (1) CA3157004A1 (pt)
IL (1) IL292009A (pt)
MX (1) MX2022004186A (pt)
WO (1) WO2021071977A1 (pt)

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JP2018501322A (ja) 2015-01-12 2018-01-18 チルドレンズ メディカル センター コーポレーション トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2023503427A (ja) * 2019-11-18 2023-01-30 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン 超活性樹状細胞は養子細胞移植に基づく持続性抗腫瘍免疫を可能にする
WO2024151124A1 (ko) * 2023-01-12 2024-07-18 주식회사 이뮤노맥스 항암능이 우수한 기억 t 세포 유래 면역세포치료제의 제조방법

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DK2322603T3 (da) * 2001-09-06 2020-01-27 Northwest Biotherapeutics Inc Sammensætninger og fremgangsmåder til aktivering af monocytiske dendritiske celler og t-celler for th1-respons
JP2018501322A (ja) * 2015-01-12 2018-01-18 チルドレンズ メディカル センター コーポレーション トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
MX2018003197A (es) * 2015-09-15 2018-09-26 Northwest Biotherapeutics Inc Métodos relacionados a composiciones de células dentríticas activadas y tratamientos inmunoterapéuticos para sujetos con cánceres avanzados.

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AU2020363707A8 (en) 2022-05-05
CA3157004A1 (en) 2021-04-15
US20240122975A1 (en) 2024-04-18
EP4041298A1 (en) 2022-08-17
MX2022004186A (es) 2022-07-19
WO2021071977A1 (en) 2021-04-15
CN115461073A (zh) 2022-12-09
AU2020363707A1 (en) 2022-04-28
JP2022552200A (ja) 2022-12-15
IL292009A (en) 2022-06-01
KR20220098351A (ko) 2022-07-12
EP4041298A4 (en) 2024-07-24

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