MX2022004186A - Composiciones y métodos in vitro para potenciar la activación de células dendríticas y células t, y para inducir una respuesta inmune th-1. - Google Patents

Composiciones y métodos in vitro para potenciar la activación de células dendríticas y células t, y para inducir una respuesta inmune th-1.

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Publication number
MX2022004186A
MX2022004186A MX2022004186A MX2022004186A MX2022004186A MX 2022004186 A MX2022004186 A MX 2022004186A MX 2022004186 A MX2022004186 A MX 2022004186A MX 2022004186 A MX2022004186 A MX 2022004186A MX 2022004186 A MX2022004186 A MX 2022004186A
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Mexico
Prior art keywords
cells
dendritic cells
compositions
activation
vitro
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MX2022004186A
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English (en)
Inventor
Marnix Leo Bosch
Linda F Powers
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Northwest Biotherapeutics Inc
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Application filed by Northwest Biotherapeutics Inc filed Critical Northwest Biotherapeutics Inc
Publication of MX2022004186A publication Critical patent/MX2022004186A/es

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

La presente descripción proporciona composiciones y métodos in vitro o ex-vivo para obtener una respuesta inmunitaria Th1 específica de antígeno potenciada. Las composiciones pueden comprender células dendríticas potenciadas por activación o células T producidas in vitro. Los métodos comprenden poner en contacto células dendríticas inmaduras con un agente de maduración que comprende un agente de maduración de células dendríticas, interferón ? y un lípido activador de la inflamación que puede producir células dendríticas hiperactivadas. El método puede comprender además poner en contacto las células dendríticas en maduración con un antígeno predeterminado durante la maduración. También se proporciona un método in vitro o ex-vivo en donde las células dendríticas hiperactivas pueden usarse para inducir la activación de células T vírgenes, en donde las células T activadas pueden formularse para su administración a un individuo que necesite dicho tratamiento.
MX2022004186A 2019-10-07 2020-10-07 Composiciones y métodos in vitro para potenciar la activación de células dendríticas y células t, y para inducir una respuesta inmune th-1. MX2022004186A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962912005P 2019-10-07 2019-10-07
PCT/US2020/054621 WO2021071977A1 (en) 2019-10-07 2020-10-07 In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response

Publications (1)

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MX2022004186A true MX2022004186A (es) 2022-07-19

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MX2022004186A MX2022004186A (es) 2019-10-07 2020-10-07 Composiciones y métodos in vitro para potenciar la activación de células dendríticas y células t, y para inducir una respuesta inmune th-1.

Country Status (11)

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US (1) US20240122975A1 (es)
EP (1) EP4041298A1 (es)
JP (1) JP2022552200A (es)
KR (1) KR20220098351A (es)
CN (1) CN115461073A (es)
AU (1) AU2020363707A1 (es)
BR (1) BR112022006743A2 (es)
CA (1) CA3157004A1 (es)
IL (1) IL292009A (es)
MX (1) MX2022004186A (es)
WO (1) WO2021071977A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023503427A (ja) * 2019-11-18 2023-01-30 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン 超活性樹状細胞は養子細胞移植に基づく持続性抗腫瘍免疫を可能にする

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016206965B2 (en) * 2015-01-12 2021-03-04 Children's Medical Center Corporation Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists
PL3350318T3 (pl) * 2015-09-15 2022-08-16 Northwest Biotherapeutics, Inc. Sposoby związane z kompozycjami aktywowanych komórek dendrytycznych dla osobników z zaawansowanymi nowotworami

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EP4041298A1 (en) 2022-08-17
KR20220098351A (ko) 2022-07-12
CA3157004A1 (en) 2021-04-15
WO2021071977A1 (en) 2021-04-15
AU2020363707A1 (en) 2022-04-28
IL292009A (en) 2022-06-01
BR112022006743A2 (pt) 2022-08-30
JP2022552200A (ja) 2022-12-15
AU2020363707A8 (en) 2022-05-05
CN115461073A (zh) 2022-12-09
US20240122975A1 (en) 2024-04-18

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