BR112022005615A2 - Peptídeos de staphylococcus e métodos de uso - Google Patents
Peptídeos de staphylococcus e métodos de usoInfo
- Publication number
- BR112022005615A2 BR112022005615A2 BR112022005615A BR112022005615A BR112022005615A2 BR 112022005615 A2 BR112022005615 A2 BR 112022005615A2 BR 112022005615 A BR112022005615 A BR 112022005615A BR 112022005615 A BR112022005615 A BR 112022005615A BR 112022005615 A2 BR112022005615 A2 BR 112022005615A2
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptide
- staphylococcus
- peptides
- methods
- lukab
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Abstract
A presente invenção refere-se a composições imunogênicas compreendendo uma variante de proteína A (SpA) de Staphylococcus aureus e um polipeptídeo da subunidade de leucocidina estafilocócica mutante compreendendo um polipeptídeo de LukA, um polipeptídeo de LukB e/ou um polipeptídeo dímero de LukAB, em que o polipeptídeo de LukA, o polipeptídeo de LukB e/ou o polipeptídeo dímero de LukAB têm uma ou mais substituições de aminoácidos, deleções ou uma combinação das mesmas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962909473P | 2019-10-02 | 2019-10-02 | |
US201962909458P | 2019-10-02 | 2019-10-02 | |
PCT/US2020/054047 WO2021067785A1 (en) | 2019-10-02 | 2020-10-02 | Staphylococcus peptides and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022005615A2 true BR112022005615A2 (pt) | 2022-07-12 |
Family
ID=73040235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022005615A BR112022005615A2 (pt) | 2019-10-02 | 2020-10-02 | Peptídeos de staphylococcus e métodos de uso |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220362368A1 (pt) |
EP (1) | EP4038091A1 (pt) |
JP (1) | JP2022550884A (pt) |
KR (1) | KR20220107166A (pt) |
CN (1) | CN115151559A (pt) |
AU (1) | AU2020358862A1 (pt) |
BR (1) | BR112022005615A2 (pt) |
CA (1) | CA3155424A1 (pt) |
CO (1) | CO2022004541A2 (pt) |
IL (1) | IL291821A (pt) |
MX (1) | MX2022004061A (pt) |
WO (1) | WO2021067785A1 (pt) |
Family Cites Families (52)
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US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4987237A (en) | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
SE8901687D0 (sv) | 1989-05-11 | 1989-05-11 | Alfa Laval Agri Int | Fibronectin binding protein as well as its preparation |
HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
JPH0655749B2 (ja) | 1989-09-20 | 1994-07-27 | 日本たばこ産業株式会社 | リピッドa単糖類縁体 |
US5593969A (en) | 1991-09-03 | 1997-01-14 | Igen Incorporated | Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors |
SG49909A1 (en) | 1992-06-25 | 1998-06-15 | Smithkline Beecham Biolog | Vaccine composition containing adjuvants |
US5648240A (en) | 1994-05-24 | 1997-07-15 | Texas A&M University | MHC II analog from Staphylococcus aureus |
US6008341A (en) | 1994-08-22 | 1999-12-28 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | S. aureus fibrinogen binding protein gene |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
JPH11514870A (ja) | 1995-10-16 | 1999-12-21 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 新規な唾液結合タンパク質 |
EP0950068B1 (en) | 1996-05-16 | 2005-11-09 | THE TEXAS A&M UNIVERSITY SYSTEM | Collagen binding protein compositions and methods of use |
JP5019494B2 (ja) | 1997-04-01 | 2012-09-05 | コリクサ コーポレーション | モノホスホリルリピドaの水性免疫アジュバント組成物 |
US6491919B2 (en) | 1997-04-01 | 2002-12-10 | Corixa Corporation | Aqueous immunologic adjuvant compostions of monophosphoryl lipid A |
US6610293B1 (en) | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
CA2337966A1 (en) | 1998-07-10 | 2000-01-20 | U.S. Medical Research Institute Of Infectious Diseases | Vaccine against staphylococcus intoxication |
IL141691A0 (en) | 1998-08-31 | 2002-03-10 | Trinity College Dublin | Polypeptides and polynucleotides from coagulase-negative staphylococci |
AU762978B2 (en) | 1998-08-31 | 2003-07-10 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
DE69940371D1 (de) | 1998-09-14 | 2009-03-19 | Nabi Biopharmaceuticals Rockvi | Beta-glucan enthaltende zusammenstellungen und spezifische immunoglobuline |
TR200101055T2 (tr) | 1998-10-16 | 2001-09-21 | Smithkline Beecham Biologicals S.A. | Adjuvan sistemler ve aşılar |
AU1431101A (en) | 1999-10-04 | 2001-05-10 | University Of Maryland Biotechnology Institute | Novel adjuvant comprising a lipopolysaccharide antagonist |
SE0000514D0 (sv) | 2000-02-17 | 2000-02-17 | Biostapro Ab | A 52 kDa protein from coagulase negative staphylococci and fragments |
DE60134499D1 (de) | 2000-04-13 | 2008-07-31 | Corixa Corp | Immunostimulierende zusammnensetzungen die aminoalkyl glucosaminidephosphat und qs-21 enthalten |
US20020169288A1 (en) | 2001-03-15 | 2002-11-14 | Magnus Hook | Collagen-binding adhesin from staphylococcus epidermidis and method of use |
US6676958B2 (en) | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
US7976852B2 (en) | 2005-04-26 | 2011-07-12 | Eisai R&D Management Co., Ltd. | Compositions and methods for cancer immunotherapy |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
US8063063B2 (en) | 2006-03-23 | 2011-11-22 | Novartis Ag | Immunopotentiating compounds |
ATE539079T1 (de) | 2006-03-23 | 2012-01-15 | Novartis Ag | Imidazochinoxalinverbindungen als immunmodulatoren |
EP2068918B1 (en) | 2006-09-26 | 2012-05-02 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
PL3281947T3 (pl) | 2009-04-03 | 2020-07-27 | The University Of Chicago | Kompozycje i sposoby związane z wariantami białka A (SpA) |
EP2437753B1 (en) | 2009-06-05 | 2016-08-31 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them |
KR101982126B1 (ko) | 2010-03-08 | 2019-05-27 | 몬산토 테크놀로지 엘엘씨 | 식물에서 유전자 조절을 위한 폴리뉴클레오타이드 분자 |
JP6031029B2 (ja) | 2010-05-05 | 2016-11-24 | ニューヨーク・ユニバーシティ | 黄色ブドウ球菌ロイコシジン、その治療用組成物、および使用 |
US11510875B2 (en) | 2012-02-07 | 2022-11-29 | Access To Advanced Health Institute | Adjuvant formulations comprising TLR4 agonists and methods of using the same |
JP6453855B2 (ja) | 2013-05-18 | 2019-01-16 | アドゥロ バイオテック,インク. | 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を活性化するための組成物及び方法 |
US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9415101B2 (en) | 2013-09-25 | 2016-08-16 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9415097B2 (en) | 2013-09-25 | 2016-08-16 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9017698B2 (en) | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9890199B2 (en) | 2013-12-09 | 2018-02-13 | Olymvax Biopharmaceuticals Inc. | Staphylococcus aureus SpA5 mutant, composition comprising mutant and preparation method and use thereof |
WO2015144691A1 (en) | 2014-03-26 | 2015-10-01 | Glaxosmithkline Biologicals Sa | Compositions for immunising against staphylococcus aureus |
RS59971B1 (sr) | 2014-03-26 | 2020-03-31 | Glaxosmithkline Biologicals Sa | Mutantni stafilokokni antigeni |
US10781246B2 (en) * | 2015-06-05 | 2020-09-22 | New York University | Compositions and methods for anti-staphylococcal biologic agents |
EP3638286A4 (en) | 2017-06-13 | 2021-03-10 | Integrated Biotherapeutic Vaccines, Inc. | IMMUNOGENIC COMPOSITIONS CONTAINING POLYPEPTIDES DERIVED FROM LEUCOCIDINS LUKA AND LUKB OF STAPHYLOCOCCUS AUREUS |
AU2018330165A1 (en) | 2017-09-08 | 2020-04-02 | Access To Advanced Health Institute | Liposomal formulations comprising saponin and methods of use |
-
2020
- 2020-10-02 KR KR1020227014713A patent/KR20220107166A/ko active Search and Examination
- 2020-10-02 AU AU2020358862A patent/AU2020358862A1/en active Pending
- 2020-10-02 WO PCT/US2020/054047 patent/WO2021067785A1/en active Application Filing
- 2020-10-02 JP JP2022520611A patent/JP2022550884A/ja active Pending
- 2020-10-02 CA CA3155424A patent/CA3155424A1/en active Pending
- 2020-10-02 US US17/764,434 patent/US20220362368A1/en active Pending
- 2020-10-02 CN CN202080082318.2A patent/CN115151559A/zh active Pending
- 2020-10-02 IL IL291821A patent/IL291821A/en unknown
- 2020-10-02 MX MX2022004061A patent/MX2022004061A/es unknown
- 2020-10-02 BR BR112022005615A patent/BR112022005615A2/pt unknown
- 2020-10-02 EP EP20800380.6A patent/EP4038091A1/en active Pending
-
2022
- 2022-04-08 CO CONC2022/0004541A patent/CO2022004541A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020358862A1 (en) | 2022-04-14 |
IL291821A (en) | 2022-06-01 |
KR20220107166A (ko) | 2022-08-02 |
US20220362368A1 (en) | 2022-11-17 |
CO2022004541A2 (es) | 2022-04-29 |
MX2022004061A (es) | 2022-07-19 |
JP2022550884A (ja) | 2022-12-05 |
CA3155424A1 (en) | 2021-04-08 |
EP4038091A1 (en) | 2022-08-10 |
WO2021067785A1 (en) | 2021-04-08 |
CN115151559A (zh) | 2022-10-04 |
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