BR112022004488A2 - Herpesvírus recombinante de vetores de peru que expressam antígenos de patógenos aviários e seus usos - Google Patents

Herpesvírus recombinante de vetores de peru que expressam antígenos de patógenos aviários e seus usos

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Publication number
BR112022004488A2
BR112022004488A2 BR112022004488A BR112022004488A BR112022004488A2 BR 112022004488 A2 BR112022004488 A2 BR 112022004488A2 BR 112022004488 A BR112022004488 A BR 112022004488A BR 112022004488 A BR112022004488 A BR 112022004488A BR 112022004488 A2 BR112022004488 A2 BR 112022004488A2
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BR
Brazil
Prior art keywords
turkey
vectors expressing
pathogen antigens
avian pathogen
recombinant
Prior art date
Application number
BR112022004488A
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English (en)
Inventor
Sing Rong
Tyler Brown
Yugang Luo
Original Assignee
Zoetis Services Llc
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Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of BR112022004488A2 publication Critical patent/BR112022004488A2/pt

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    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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Abstract

herpesvírus recombinante de vetores de peru que expressam antígenos de patógenos aviários e seus usos. a invenção se refere a vetores virais recombinantes para inserção e expressão de genes estranhos para uso em imunizações seguras para proteção contra uma variedade de patógenos. a invenção também se refere a composições ou vacinas multivalentes compreendendo um ou mais vetores virais recombinantes para proteção contra uma variedade de patógenos. a presente invenção se refere a métodos de produção usando os referidos vetores virais recombinantes
BR112022004488A 2019-09-11 2020-09-10 Herpesvírus recombinante de vetores de peru que expressam antígenos de patógenos aviários e seus usos BR112022004488A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962898651P 2019-09-11 2019-09-11
PCT/US2020/050164 WO2021050701A1 (en) 2019-09-11 2020-09-10 Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof

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BR112022004488A2 true BR112022004488A2 (pt) 2022-05-31

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US (2) US11464849B2 (pt)
EP (1) EP4028510A1 (pt)
JP (1) JP2022547975A (pt)
KR (1) KR20220056241A (pt)
CN (1) CN114616325A (pt)
AU (1) AU2020347180A1 (pt)
BR (1) BR112022004488A2 (pt)
CA (1) CA3153379A1 (pt)
CO (1) CO2022004470A2 (pt)
IL (1) IL290899A (pt)
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WO2021050701A1 (en) * 2019-09-11 2021-03-18 Zoetis Services Llc Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof
CN112048484A (zh) * 2020-07-27 2020-12-08 华南农业大学 一株表达传染性法氏囊强毒株vp2蛋白的基因ⅶ型新城疫重组病毒和疫苗
CN116042709A (zh) * 2022-09-23 2023-05-02 广西大学 一种共表达马立克病病毒糖蛋白gC和gD的DNA疫苗构建方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965138A (en) 1985-09-06 1999-10-12 Syntro Corporation Recombinant chimeric virus and uses thereof
US5834305A (en) 1985-09-06 1998-11-10 Syntro Corporation Attenuated herpesvirus, herpesvirus which include foreign DNA encoding an amino acid sequence and vaccines containing same
US6121043A (en) 1985-09-06 2000-09-19 Syntro Corporation Recombinant herpesvirus of turkeys comprising a foreign DNA inserted into a non-essential region of the herpesvirus of turkeys genome
WO1987004463A1 (en) 1986-01-27 1987-07-30 Syntro Corporation Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same
JP2779447B2 (ja) 1988-03-20 1998-07-23 財団法人阪大微生物病研究会 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体
ATE150976T1 (de) 1989-10-02 1997-04-15 Univ Arkansas Impfstoff-konjugate zur behandlung von vogelkrankheiten
EP0431668B1 (en) * 1989-12-04 1995-02-15 Akzo Nobel N.V. Recombinant herpesvirus of turkeys and live vector vaccines derived thereof
US5231023A (en) 1990-07-30 1993-07-27 Akzo N.V. Recombinant Marek's disease virus
US5350576A (en) 1991-09-13 1994-09-27 Mycogen Corporation Bacillus thuringiensis isolates for controlling acarides
US6183753B1 (en) 1994-08-09 2001-02-06 Schering-Plough Veterinary Corp. Recombinant chimeric virus and uses thereof
US5853733A (en) 1993-02-26 1998-12-29 Syntro Corporation Recombinant herpesvirus of turkeys and uses thereof
FR2728795B1 (fr) 1994-12-30 1997-03-21 Rhone Merieux Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire
DE69632235T2 (de) * 1995-10-18 2004-08-26 Akzo Nobel N.V. Newcastle-Krankheitsvirus-Kombinationsimpfstoff
US6194167B1 (en) 1997-02-18 2001-02-27 Washington State University Research Foundation ω-3 fatty acid desaturase
US6048535A (en) 1997-06-12 2000-04-11 Regents Of The University Of Minnesota Multivalent in ovo avian vaccine
DE69836557T2 (de) 1997-10-03 2007-09-20 Zeon Corp. Rekombinanten des infektiösen vogel-herpesvirus und rekombinante impfstoffe, die unter dessen verwendung hergestellt wurden
CZ301524B6 (cs) 1999-03-18 2010-03-31 Merck Patent Gmbh Polypeptid z H. medicinalis, zpusob jeho prípravy a použití, farmaceutický prostredek, polynukleotid, expresní vektor, hostitelská bunka, protilátka a její použití
US6299882B1 (en) 1999-04-09 2001-10-09 Schering Corporation UL54.5 of Marek's disease virus (MDV)
US6790639B2 (en) 2000-02-29 2004-09-14 Pfizer Inc. Mammalian osteoregulins
US6764684B2 (en) 2001-09-28 2004-07-20 Zeon Corporation Avian herpesvirus-based recombinant infectious bursal disease vaccine
US6866852B2 (en) 2002-01-31 2005-03-15 Zeon Corporation Recombinant herpesvirus of turkeys and use thereof
JP2008228658A (ja) 2007-03-20 2008-10-02 Nippon Zeon Co Ltd 新規なプロモーター、これを有する組み換え七面鳥ヘルペスウイルス、及びこれを利用した家禽用ワクチン
BR112014008161A2 (pt) 2011-10-21 2017-04-11 Intervet Int Bv vírus da doença de marek não patogênico recombinante, método para a preparação do mesmo, molécula do ácido nucleico, célula hospedeira, vacina para aves domésticas, método para a preparação de uma vacina, uso de um vírus da doença de marek não patogênico recombinante, e, método de vacinação de aves domésticas
ES2700243T3 (es) 2011-10-21 2019-02-14 Intervet Int Bv Construcciones del virus de la enfermedad de Marek recombinantes no patógenas que codifican antígenos del virus de la laringotraqueitis infecciosa y del virus de la enfermedad de Newcastle
US9101598B2 (en) * 2011-11-30 2015-08-11 Merial, Inc. Recombinant Gallid herpesvirus 3 (MDV serotype 2) vectors expressing antigens of avian pathogens and uses thereof
PT2785373T (pt) 2011-11-30 2020-01-27 Boehringer Ingelheim Animal Health Usa Inc Vectores de hvt recombinantes expressando antigénios de agentes patogénicos aviários e seus usos
EP2644702A1 (en) 2012-03-30 2013-10-02 Ceva Sante Animale Multivalent recombinant avian herpes virus and vaccine for immunizing avian species
AR103245A1 (es) 2014-12-24 2017-04-26 Intervet Int Bv Vacuna vectorial basada en hvt (herpes virus de los pavos) frente a nd (enfermedad de newcastle) - ibd (enfermedad de gumboro) mejorada
JP7046014B2 (ja) 2016-06-17 2022-04-01 インターベット インターナショナル ベー． フェー． 伝染性喉頭気管炎ウイルスおよび伝染性ファブリキウス嚢病ウイルスの抗原をコードする組換え非病原性マレック病ウイルスコンストラクト
JOP20190088A1 (ar) 2016-10-21 2019-04-21 Us Agriculture نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها
CN117357642A (zh) 2016-12-14 2024-01-09 勃林格殷格翰动物保健美国公司 表达禽病原体的多种抗原的重组hvt载体及其用途
US20220040287A1 (en) 2018-12-21 2022-02-10 Ceva Sante Animale Recombinant avian herpes viruses containing multiple foreign genes
WO2021050701A1 (en) * 2019-09-11 2021-03-18 Zoetis Services Llc Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof

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