CO2023000493A2 - Vectores de hvt recombinantes que expresan hemaglutinina de influenza y composiciones inmunogénicas, y producción y usos de estos - Google Patents

Vectores de hvt recombinantes que expresan hemaglutinina de influenza y composiciones inmunogénicas, y producción y usos de estos

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Publication number
CO2023000493A2
CO2023000493A2 CONC2023/0000493A CO2023000493A CO2023000493A2 CO 2023000493 A2 CO2023000493 A2 CO 2023000493A2 CO 2023000493 A CO2023000493 A CO 2023000493A CO 2023000493 A2 CO2023000493 A2 CO 2023000493A2
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Colombia
Prior art keywords
viral vectors
immunogenic compositions
production
influenza hemagglutinin
vectors expressing
Prior art date
Application number
CONC2023/0000493A
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English (en)
Inventor
Teshome Mebatsion
Aemro Kassa
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Boehringer Ingelheim Vetmedica Gmbh
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Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of CO2023000493A2 publication Critical patent/CO2023000493A2/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/255—Marek's disease virus
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    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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Abstract

[00540] La invención se relaciona con vectores virales recombinantes y composiciones que incluyen los mismos para usar como vehículos para inducir una respuesta inmunológica. Los vectores virales multivalentes se pueden usar en composiciones o vacunas que contienen uno o más vectores virales recombinantes para la protección contra una variedad de patógenos. Además, la presente invención se relaciona con la formación de estos vectores virales puede incluir la inserción y expresión de genes extraños para la protección contra una variedad de patógenos. Se proveen además métodos de elaboración y uso de vectores virales recombinantes, así como composiciones inmunogénicas que incluyen los vectores y/o antígenos. En particular, las composiciones inmunogénicas pueden incluir vectores virales recombinantes, tales como vHVT509, vHVT522 y/o vHVT523.
CONC2023/0000493A 2020-06-17 2023-01-16 Vectores de hvt recombinantes que expresan hemaglutinina de influenza y composiciones inmunogénicas, y producción y usos de estos CO2023000493A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063040411P 2020-06-17 2020-06-17
PCT/US2021/037631 WO2021257706A1 (en) 2020-06-17 2021-06-16 Recombinant hvt vectors expressing influenza hemagglutinin and immunogenic compositions, and production and uses thereof

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CO2023000493A2 true CO2023000493A2 (es) 2023-01-26

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EP (1) EP4168043A1 (es)
KR (1) KR20230040328A (es)
CN (1) CN116472057A (es)
AR (1) AR122653A1 (es)
BR (1) BR112022025733A2 (es)
CA (1) CA3186579A1 (es)
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IL (1) IL299033A (es)
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WO2017216287A1 (en) 2016-06-17 2017-12-21 Intervet International B.V. Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and infectious bursal disease virus antigens

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60500673A (ja) 1983-03-08 1985-05-09 コモンウエルス　セラム　ラボラトリ−ズ　コミツシヨン 抗原活性を有するアミノ酸配列
US5965138A (en) 1985-09-06 1999-10-12 Syntro Corporation Recombinant chimeric virus and uses thereof
US5961982A (en) 1985-09-06 1999-10-05 Syntro Corporation Recombinant herpesvirus of turkeys and uses thereof
WO1987004463A1 (en) 1986-01-27 1987-07-30 Syntro Corporation Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same
JP2779447B2 (ja) 1988-03-20 1998-07-23 財団法人阪大微生物病研究会 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体
ES2070997T3 (es) 1989-12-04 1995-06-16 Akzo Nobel Nv Virus de herpes recombinante de pavos y vacunas vector vivas derivadas de los mismos.
BE1004877A3 (fr) 1991-05-27 1993-02-16 Solvay Virus de l'avipox recombinant, culture de cellules infectees par ce virus et vaccins pour la volaille derives de ce virus.
US6183753B1 (en) 1994-08-09 2001-02-06 Schering-Plough Veterinary Corp. Recombinant chimeric virus and uses thereof
US5853733A (en) 1993-02-26 1998-12-29 Syntro Corporation Recombinant herpesvirus of turkeys and uses thereof
FR2728795B1 (fr) 1994-12-30 1997-03-21 Rhone Merieux Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire
US6299882B1 (en) 1999-04-09 2001-10-09 Schering Corporation UL54.5 of Marek's disease virus (MDV)
US6764684B2 (en) 2001-09-28 2004-07-20 Zeon Corporation Avian herpesvirus-based recombinant infectious bursal disease vaccine
US6866852B2 (en) 2002-01-31 2005-03-15 Zeon Corporation Recombinant herpesvirus of turkeys and use thereof
US20110110887A1 (en) 2008-06-23 2011-05-12 Wilhelmus Gerardus Johannes Degen Recombinant herpesvirus of turkeys encoding for interleukin-12
EP2768529A1 (en) 2011-10-21 2014-08-27 Intervet International B.V. Recombinant nonpathogenic mdv vector providing multivalent immunity
US9114108B2 (en) 2011-11-30 2015-08-25 Merial, Inc. Recombinant HVT vectors expressing antigens of avian pathogens and uses thereof
ES2719409T5 (es) 2011-11-30 2022-12-07 Boehringer Ingelheim Animal Health Usa Inc Vectores recombinantes de Gallid herpesvirus 3 (mdv serotipo 2) que expresan antígenos de patógenos aviares y usos de los mismos
EP2644702A1 (en) 2012-03-30 2013-10-02 Ceva Sante Animale Multivalent recombinant avian herpes virus and vaccine for immunizing avian species
AR097029A1 (es) 2013-07-26 2016-02-17 Intervet Int Bv Aceleración de la respuesta inmune inducida por virus vectorial en aves, composición, uso, método para la vacunación y método para acelerar la respuesta inmune
EP2845904A1 (en) 2013-09-06 2015-03-11 Ceva Sante Animale Recombinant Marek's disease viruses and uses thereof
AR103245A1 (es) 2014-12-24 2017-04-26 Intervet Int Bv Vacuna vectorial basada en hvt (herpes virus de los pavos) frente a nd (enfermedad de newcastle) - ibd (enfermedad de gumboro) mejorada
MA55772A (fr) * 2016-12-14 2022-03-02 Boehringer Ingelheim Animal Health Usa Inc Vecteurs hvt recombinants exprimant de multiples antigènes de pathogènes aviaires, et vaccins les contenant
EP3391903B1 (en) * 2017-04-21 2022-02-23 The Pirbright Institute Recombinant gallid herpesvirus 3 vaccines encoding heterologous avian pathogen antigens

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IL299033A (en) 2023-02-01
KR20230040328A (ko) 2023-03-22
CN116472057A (zh) 2023-07-21
MX2022016337A (es) 2023-04-10
EP4168043A1 (en) 2023-04-26
AR122653A1 (es) 2022-09-28
BR112022025733A2 (pt) 2023-03-07

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