BR112021025532A2 - Processos e intermediários para a preparação de 2-(2,6-diclorofenil) 1 [(1s,3r) 3 (hidroximetil) 5 (3 hidro-xi 3 metilbutil) 1 metil 3,4 di hidroisoquinolin 2(1h) il]etenona - Google Patents

Processos e intermediários para a preparação de 2-(2,6-diclorofenil) 1 [(1s,3r) 3 (hidroximetil) 5 (3 hidro-xi 3 metilbutil) 1 metil 3,4 di hidroisoquinolin 2(1h) il]etenona

Info

Publication number
BR112021025532A2
BR112021025532A2 BR112021025532A BR112021025532A BR112021025532A2 BR 112021025532 A2 BR112021025532 A2 BR 112021025532A2 BR 112021025532 A BR112021025532 A BR 112021025532A BR 112021025532 A BR112021025532 A BR 112021025532A BR 112021025532 A2 BR112021025532 A2 BR 112021025532A2
Authority
BR
Brazil
Prior art keywords
intermediates
processes
preparation
ethenone
dihydroisoquinolin
Prior art date
Application number
BR112021025532A
Other languages
English (en)
Inventor
Paul Cole Kevin
John Kallman Neil
Andrew Magnus Nicholas
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112021025532A2 publication Critical patent/BR112021025532A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

processos e intermediários para a preparação de 2- (2,6-diclorofenil) 1 [(1s,3r) 3 (hidroximetil) 5 (3 hidro-xi 3 metilbutil) 1 metil 3,4 di hidroisoquinolin 2(1h) il]etenona. trata se de processos e intermediários para a preparação de d1 pam i: fórmula (i).
BR112021025532A 2019-06-18 2020-06-11 Processos e intermediários para a preparação de 2-(2,6-diclorofenil) 1 [(1s,3r) 3 (hidroximetil) 5 (3 hidro-xi 3 metilbutil) 1 metil 3,4 di hidroisoquinolin 2(1h) il]etenona BR112021025532A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962862805P 2019-06-18 2019-06-18
PCT/US2020/037186 WO2020257043A1 (en) 2019-06-18 2020-06-11 Processes and intermediates for the preparation of 2-(2,6-dichlorophenyl)-1-[(1s,3r)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1h)-yl]ethenone

Publications (1)

Publication Number Publication Date
BR112021025532A2 true BR112021025532A2 (pt) 2022-04-19

Family

ID=71950727

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021025532A BR112021025532A2 (pt) 2019-06-18 2020-06-11 Processos e intermediários para a preparação de 2-(2,6-diclorofenil) 1 [(1s,3r) 3 (hidroximetil) 5 (3 hidro-xi 3 metilbutil) 1 metil 3,4 di hidroisoquinolin 2(1h) il]etenona

Country Status (16)

Country Link
US (1) US20220242826A1 (pt)
EP (1) EP3986867B1 (pt)
JP (2) JP7354303B2 (pt)
KR (1) KR102642754B1 (pt)
CN (1) CN113993849A (pt)
AR (1) AR119123A1 (pt)
AU (1) AU2020297336B2 (pt)
BR (1) BR112021025532A2 (pt)
CA (3) CA3143463A1 (pt)
EA (1) EA202193105A1 (pt)
ES (1) ES2960876T3 (pt)
IL (1) IL288521A (pt)
MA (1) MA56540A (pt)
MX (1) MX2021015326A (pt)
TW (1) TWI825323B (pt)
WO (1) WO2020257043A1 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30244A1 (es) * 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
JO3316B1 (ar) * 2013-05-30 2019-03-13 Lilly Co Eli مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل
AR106332A1 (es) * 2015-10-23 2018-01-03 Lilly Co Eli Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona

Also Published As

Publication number Publication date
CA3219063A1 (en) 2020-12-24
KR20220008902A (ko) 2022-01-21
TWI825323B (zh) 2023-12-11
CN113993849A (zh) 2022-01-28
TW202114992A (zh) 2021-04-16
EP3986867A1 (en) 2022-04-27
JP7354303B2 (ja) 2023-10-02
AU2020297336B2 (en) 2023-08-10
CA3143463A1 (en) 2020-12-24
IL288521A (en) 2022-01-01
JP2023179519A (ja) 2023-12-19
CA3219030A1 (en) 2020-12-24
JP2022537380A (ja) 2022-08-25
EP3986867B1 (en) 2023-09-13
AR119123A1 (es) 2021-11-24
KR102642754B1 (ko) 2024-03-05
ES2960876T3 (es) 2024-03-07
US20220242826A1 (en) 2022-08-04
AU2020297336A1 (en) 2022-01-06
WO2020257043A1 (en) 2020-12-24
MX2021015326A (es) 2022-01-18
MA56540A (fr) 2022-04-27
EA202193105A1 (ru) 2022-03-11

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