AR106332A1 - Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona - Google Patents
Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanonaInfo
- Publication number
- AR106332A1 AR106332A1 ARP160103122A ARP160103122A AR106332A1 AR 106332 A1 AR106332 A1 AR 106332A1 AR P160103122 A ARP160103122 A AR P160103122A AR P160103122 A ARP160103122 A AR P160103122A AR 106332 A1 AR106332 A1 AR 106332A1
- Authority
- AR
- Argentina
- Prior art keywords
- dihydroisoquinolin
- methylbutyl
- hydroxy
- methyl
- crystalline form
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Abstract
Reivindicación 1: Una forma cristalina caracterizada porque es de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona. Reivindicación 2: La forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona de conformidad con la reivindicación 1, caracterizada por un patrón de difracción en polvo de rayos-X usando radiación CuKa que tiene un pico de difracción en ángulo de difracción 2-q de 9.15º en combinación con uno o más picos seleccionados a partir del grupo que consiste de 19.4º, 16.1º, y 16.6º; con una tolerancia para los ángulos de difracción de 0.2 grados.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562245391P | 2015-10-23 | 2015-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR106332A1 true AR106332A1 (es) | 2018-01-03 |
Family
ID=57233858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160103122A AR106332A1 (es) | 2015-10-23 | 2016-10-13 | Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona |
Country Status (13)
Country | Link |
---|---|
CN (1) | CN108137506A (es) |
AR (1) | AR106332A1 (es) |
AU (1) | AU2016341115A1 (es) |
CA (1) | CA2999332A1 (es) |
DO (1) | DOP2018000103A (es) |
EA (1) | EA201890525A1 (es) |
EC (1) | ECSP18030976A (es) |
IL (1) | IL257872A (es) |
MX (1) | MX2018004794A (es) |
PE (1) | PE20181296A1 (es) |
PH (1) | PH12018500859A1 (es) |
TW (1) | TW201725199A (es) |
WO (1) | WO2017070068A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI725408B (zh) * | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
AU2019402087B2 (en) * | 2018-12-18 | 2023-04-06 | Eli Lilly And Company | Dose regimens for use of LY3154207 in the treatment of dopaminergic CNS disorders |
TWI825323B (zh) * | 2019-06-18 | 2023-12-11 | 美商美國禮來大藥廠 | 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物 |
EP4304581A1 (en) | 2021-03-08 | 2024-01-17 | Eli Lilly And Co. | Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis |
CN117337173A (zh) | 2021-03-09 | 2024-01-02 | 伊莱利利公司 | 美维达林和其他d1正向别构调节剂用于减缓帕金森氏病进展的用途 |
CN113264926A (zh) * | 2021-05-31 | 2021-08-17 | 东北林业大学 | 一种牡荆素与利血平的共晶及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5236934A (en) * | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
KR20090127307A (ko) * | 2007-03-01 | 2009-12-10 | 얀센 파마슈티카 엔.브이. | 히스타민 h3 수용체 조절제로서의 테트라하이드로이소퀴놀린 화합물 |
US20120252853A1 (en) * | 2011-04-01 | 2012-10-04 | H. Lundbeck A/S | Positive allosteric modulators of nicotinic acetylcholine receptor |
JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
-
2016
- 2016-10-13 AR ARP160103122A patent/AR106332A1/es unknown
- 2016-10-14 TW TW105133203A patent/TW201725199A/zh unknown
- 2016-10-18 AU AU2016341115A patent/AU2016341115A1/en not_active Abandoned
- 2016-10-18 MX MX2018004794A patent/MX2018004794A/es unknown
- 2016-10-18 EA EA201890525A patent/EA201890525A1/ru unknown
- 2016-10-18 PE PE2018000570A patent/PE20181296A1/es not_active Application Discontinuation
- 2016-10-18 CA CA2999332A patent/CA2999332A1/en not_active Abandoned
- 2016-10-18 CN CN201680061907.6A patent/CN108137506A/zh active Pending
- 2016-10-18 WO PCT/US2016/057447 patent/WO2017070068A1/en active Application Filing
-
2018
- 2018-03-05 IL IL257872A patent/IL257872A/en unknown
- 2018-04-20 PH PH12018500859A patent/PH12018500859A1/en unknown
- 2018-04-20 EC ECIEPI201830976A patent/ECSP18030976A/es unknown
- 2018-04-20 DO DO2018000103A patent/DOP2018000103A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL257872A (en) | 2018-06-03 |
AU2016341115A1 (en) | 2018-04-12 |
PH12018500859A1 (en) | 2018-10-29 |
ECSP18030976A (es) | 2018-05-31 |
CN108137506A (zh) | 2018-06-08 |
PE20181296A1 (es) | 2018-08-07 |
TW201725199A (zh) | 2017-07-16 |
EA201890525A1 (ru) | 2018-09-28 |
CA2999332A1 (en) | 2017-04-27 |
WO2017070068A1 (en) | 2017-04-27 |
MX2018004794A (es) | 2018-06-19 |
DOP2018000103A (es) | 2018-10-31 |
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