BR112021025179A2 - Antagonistas 5 ht2 tricíclicos - Google Patents
Antagonistas 5 ht2 tricíclicosInfo
- Publication number
- BR112021025179A2 BR112021025179A2 BR112021025179A BR112021025179A BR112021025179A2 BR 112021025179 A2 BR112021025179 A2 BR 112021025179A2 BR 112021025179 A BR112021025179 A BR 112021025179A BR 112021025179 A BR112021025179 A BR 112021025179A BR 112021025179 A2 BR112021025179 A2 BR 112021025179A2
- Authority
- BR
- Brazil
- Prior art keywords
- tricyclic
- relates
- antagonists
- compounds
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
antagonistas 5-ht2 tricíclicos. a presente invenção se refere a derivados tricíclicos de 1 amidino 4 metil [2,3 fundido] 2 pirrolina da fórmula geral (i). a invenção refere se especificamente a tais derivados que exibem atividade antagonista em relação aos receptores 5 ht2b da serotonina. a presente invenção também se refere ao uso dos ditos compostos como um medicamento e para o tratamento de fibrose, doenças cardiovasculares, dor, dii, doenças inflamatórias e câncer, bem como composições farmacêuticas que compreendem um ou mais dos ditos compostos e métodos de tratamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19180740.3A EP3753924A1 (en) | 2019-06-18 | 2019-06-18 | New tricyclic 5-ht2 antagonists |
PCT/EP2020/066627 WO2020254322A1 (en) | 2019-06-18 | 2020-06-16 | New tricyclic 5-ht2 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021025179A2 true BR112021025179A2 (pt) | 2022-02-01 |
Family
ID=66951850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021025179A BR112021025179A2 (pt) | 2019-06-18 | 2020-06-16 | Antagonistas 5 ht2 tricíclicos |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220267268A1 (pt) |
EP (2) | EP3753924A1 (pt) |
JP (1) | JP2022537528A (pt) |
KR (1) | KR20220023982A (pt) |
CN (1) | CN114616224A (pt) |
AU (1) | AU2020295685A1 (pt) |
BR (1) | BR112021025179A2 (pt) |
CA (1) | CA3141747A1 (pt) |
IL (1) | IL288514A (pt) |
MX (1) | MX2021015526A (pt) |
WO (1) | WO2020254322A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11952378B1 (en) * | 2023-12-14 | 2024-04-09 | King Faisal University | Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9103839D0 (en) * | 1991-02-23 | 1991-04-10 | Smithkline Beecham Plc | Pharmaceuticals |
ES2250667T3 (es) * | 2001-07-13 | 2006-04-16 | PHARMACIA & UPJOHN COMPANY LLC | Hexahidroazepino(4,5-g)indoles e indolinas como ligandos del receptor 5-ht. |
ATE544750T1 (de) * | 2001-09-21 | 2012-02-15 | Bristol Myers Squibb Co | Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer |
WO2005080322A1 (ja) | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | フルオレン誘導体 |
KR20080094962A (ko) | 2006-02-20 | 2008-10-27 | 아스텔라스세이야쿠 가부시키가이샤 | 아미드 유도체 또는 그의 염 |
CN101910157B (zh) * | 2007-11-16 | 2014-05-07 | 纽尔亚商股份有限公司 | 吲哚化合物和治疗内脏痛的方法 |
CA2741511C (en) | 2008-11-21 | 2017-01-24 | Raqualia Pharma Inc. | Novel pyrazole-3-carboxamide derivative having 5-ht2b receptor antagonist activity |
EP3109237A1 (en) * | 2015-06-22 | 2016-12-28 | AnaMar AB | Novel 5-ht2 antagonists |
-
2019
- 2019-06-18 EP EP19180740.3A patent/EP3753924A1/en not_active Withdrawn
-
2020
- 2020-06-16 JP JP2021573946A patent/JP2022537528A/ja active Pending
- 2020-06-16 WO PCT/EP2020/066627 patent/WO2020254322A1/en unknown
- 2020-06-16 US US17/619,359 patent/US20220267268A1/en active Pending
- 2020-06-16 EP EP20733583.7A patent/EP3986865A1/en active Pending
- 2020-06-16 KR KR1020217040342A patent/KR20220023982A/ko unknown
- 2020-06-16 CN CN202080044100.8A patent/CN114616224A/zh active Pending
- 2020-06-16 AU AU2020295685A patent/AU2020295685A1/en active Pending
- 2020-06-16 BR BR112021025179A patent/BR112021025179A2/pt not_active Application Discontinuation
- 2020-06-16 CA CA3141747A patent/CA3141747A1/en active Pending
- 2020-06-16 MX MX2021015526A patent/MX2021015526A/es unknown
-
2021
- 2021-11-29 IL IL288514A patent/IL288514A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020254322A1 (en) | 2020-12-24 |
EP3986865A1 (en) | 2022-04-27 |
CN114616224A (zh) | 2022-06-10 |
AU2020295685A1 (en) | 2021-12-23 |
IL288514A (en) | 2022-01-01 |
US20220267268A1 (en) | 2022-08-25 |
CA3141747A1 (en) | 2020-12-24 |
KR20220023982A (ko) | 2022-03-03 |
EP3753924A1 (en) | 2020-12-23 |
JP2022537528A (ja) | 2022-08-26 |
MX2021015526A (es) | 2022-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |