BR112021022182A2 - Método para produção de lipossomas. - Google Patents
Método para produção de lipossomas.Info
- Publication number
- BR112021022182A2 BR112021022182A2 BR112021022182A BR112021022182A BR112021022182A2 BR 112021022182 A2 BR112021022182 A2 BR 112021022182A2 BR 112021022182 A BR112021022182 A BR 112021022182A BR 112021022182 A BR112021022182 A BR 112021022182A BR 112021022182 A2 BR112021022182 A2 BR 112021022182A2
- Authority
- BR
- Brazil
- Prior art keywords
- liposomes
- producing liposomes
- producing
- antirheumatic
- antipyretic
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 5
- 239000002502 liposome Substances 0.000 title abstract 4
- -1 anti-inflammatory Substances 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 238000001125 extrusion Methods 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
método para a produção de lipossomas. a presente divulgação refere-se a um método para a produção de lipossomas, de modo a se obter uma elevada eficácia de encapsulamento de agentes encapsulados com um número reduzido de passos de produção, evitando-se nomeadamente o passo de extrusão do processo clássico de produção lipossomal. os lipossomas da invenção destinam-se a transportar um agente terapêutico como um agente anticâncer, antioxidante, anti-inflamatório, antipirético, antibiótico, antiviral, antirreumático, analgésico, fator de crescimento, ou suas misturas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT11550019 | 2019-05-07 | ||
| PCT/IB2020/054346 WO2020225769A1 (en) | 2019-05-07 | 2020-05-07 | Method for production of liposomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021022182A2 true BR112021022182A2 (pt) | 2021-12-21 |
Family
ID=71083668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021022182A BR112021022182A2 (pt) | 2019-05-07 | 2020-05-07 | Método para produção de lipossomas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220241203A1 (pt) |
| EP (1) | EP3965738A1 (pt) |
| JP (1) | JP2022531610A (pt) |
| KR (1) | KR20220005446A (pt) |
| CN (2) | CN118203546A (pt) |
| AU (1) | AU2020269626A1 (pt) |
| BR (1) | BR112021022182A2 (pt) |
| CA (1) | CA3137789A1 (pt) |
| WO (1) | WO2020225769A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4247339A4 (en) * | 2020-12-01 | 2024-05-15 | Ege Universitesi | TARGETED DRUG DELIVERY SYSTEM WITH CURCUMIN SUPPLEMENT IN THE TREATMENT OF GLIOBLASTOMA |
| WO2023056089A1 (en) * | 2021-10-03 | 2023-04-06 | Eisai R&D Management Co., Ltd. | Immunological adjuvant formulations comprising tlr4 agonist e6020 |
| US11926579B1 (en) | 2023-10-31 | 2024-03-12 | King Faisal University | 8-(4-methoxybenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752425A (en) | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| EP0825852B1 (en) | 1995-04-18 | 2004-07-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
| BR0012624B1 (pt) | 1999-07-15 | 2011-08-09 | métodos para a preparação de agentes terapêuticos envolvidos por lipìdeos. | |
| CN101744767B (zh) * | 2008-12-05 | 2013-02-13 | 中国人民解放军军事医学科学院毒物药物研究所 | 包含喜树碱类抗肿瘤药物的热敏脂质体制剂 |
| AU2011353698B2 (en) | 2011-01-05 | 2017-05-11 | Livon Laboratories | Methods of making liposomes, liposome compositions made by the methods, and methods of using the same |
| EP2773328A2 (en) | 2011-11-04 | 2014-09-10 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| PT2789348T (pt) | 2011-12-07 | 2021-11-11 | Univ Do Minho | Lipossomas e método de produção correspondente |
| EP3188724B1 (en) * | 2014-08-14 | 2021-11-10 | L.E.A.F Holdings Group LLC | Liposome encapsulated affinity drug |
| WO2017223135A1 (en) * | 2016-06-24 | 2017-12-28 | Modernatx, Inc. | Lipid nanoparticles |
-
2020
- 2020-05-07 WO PCT/IB2020/054346 patent/WO2020225769A1/en unknown
- 2020-05-07 AU AU2020269626A patent/AU2020269626A1/en active Pending
- 2020-05-07 EP EP20732313.0A patent/EP3965738A1/en active Pending
- 2020-05-07 BR BR112021022182A patent/BR112021022182A2/pt unknown
- 2020-05-07 KR KR1020217032697A patent/KR20220005446A/ko unknown
- 2020-05-07 US US17/607,714 patent/US20220241203A1/en active Pending
- 2020-05-07 CN CN202410307863.7A patent/CN118203546A/zh active Pending
- 2020-05-07 CN CN202080033425.6A patent/CN113825497A/zh active Pending
- 2020-05-07 CA CA3137789A patent/CA3137789A1/en active Pending
- 2020-05-07 JP JP2021566082A patent/JP2022531610A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020225769A1 (en) | 2020-11-12 |
| KR20220005446A (ko) | 2022-01-13 |
| CN113825497A (zh) | 2021-12-21 |
| EP3965738A1 (en) | 2022-03-16 |
| JP2022531610A (ja) | 2022-07-07 |
| AU2020269626A1 (en) | 2021-10-28 |
| CA3137789A1 (en) | 2020-11-12 |
| CN118203546A (zh) | 2024-06-18 |
| US20220241203A1 (en) | 2022-08-04 |
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