BR112018073117A2 - método para produção de celastrol e derivados de triterpeno pentacíclicos - Google Patents

método para produção de celastrol e derivados de triterpeno pentacíclicos

Info

Publication number
BR112018073117A2
BR112018073117A2 BR112018073117-0A BR112018073117A BR112018073117A2 BR 112018073117 A2 BR112018073117 A2 BR 112018073117A2 BR 112018073117 A BR112018073117 A BR 112018073117A BR 112018073117 A2 BR112018073117 A2 BR 112018073117A2
Authority
BR
Brazil
Prior art keywords
celastrol
production
pentacyclic triterpene
extract
triterpene derivatives
Prior art date
Application number
BR112018073117-0A
Other languages
English (en)
Other versions
BR112018073117B1 (pt
Inventor
Nguyen Thien
COUSY Adrien
Steward Nicolas
Original Assignee
Pierre Fabre Dermo-Cosmetique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Dermo-Cosmetique filed Critical Pierre Fabre Dermo-Cosmetique
Publication of BR112018073117A2 publication Critical patent/BR112018073117A2/pt
Publication of BR112018073117B1 publication Critical patent/BR112018073117B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/11—Preparation or pretreatment of starting material involving culturing conditions, e.g. cultivation in the dark or under defined water stress

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a presente invenção refere-se a um processo de produção de um extrato bruto enriquecido em terpenos pentacíclicos, incluindo celastrol, partindo de células de uma planta da família celastraceae; um extrato bruto enriquecido que pode ser obtido utilizando tal processo; aplicações terapêuticas de tal extrato; e composições farmacêuticas e dermocosméticas que contêm tal extrato.
BR112018073117-0A 2016-05-12 2017-05-12 Processo de produção de um extrato bruto enriquecido com triterpenos pentacíclicos BR112018073117B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1654240A FR3051116B1 (fr) 2016-05-12 2016-05-12 Procede de production du celastrol et de derives triterpeniques pentacycliques
FR1654240 2016-05-12
PCT/EP2017/061504 WO2017194757A1 (fr) 2016-05-12 2017-05-12 Procede de production du celastrol et de derives triterpeniques pentacycliques

Publications (2)

Publication Number Publication Date
BR112018073117A2 true BR112018073117A2 (pt) 2019-03-06
BR112018073117B1 BR112018073117B1 (pt) 2022-10-25

Family

ID=56404155

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018073117-0A BR112018073117B1 (pt) 2016-05-12 2017-05-12 Processo de produção de um extrato bruto enriquecido com triterpenos pentacíclicos

Country Status (12)

Country Link
US (1) US20190134128A1 (pt)
EP (1) EP3454875B1 (pt)
KR (1) KR102513830B1 (pt)
BR (1) BR112018073117B1 (pt)
CA (1) CA3023192A1 (pt)
ES (1) ES2831835T3 (pt)
FR (1) FR3051116B1 (pt)
MX (1) MX2018013728A (pt)
PT (1) PT3454875T (pt)
RU (1) RU2743715C1 (pt)
SG (1) SG11201809948XA (pt)
WO (1) WO2017194757A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3047665B1 (fr) * 2016-02-17 2020-12-11 Pf Medicament Celastrol et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees
LU101117B1 (en) * 2019-02-07 2020-08-07 Luxembourg Institute Of Science And Tech (List) METHOD FOR PRODUCING A COMPOSITION COMPRISING A 3-O-p-COUMAROYL ESTER OF TORMENTIC ACID FROM A PLANT CELL CULTURE, APPLICATIONS THEREOF AS ANTIPARASITIC AGENT FOR THE TREATMENT OF TRYPANOSOMIASIS
FR3095754B1 (fr) * 2019-05-10 2021-11-19 Fabre Pierre Dermo Cosmetique Triterpènes pentacycliques dans le traitement du vitiligo
FR3120790B1 (fr) 2021-03-10 2024-03-15 Fabre Pierre Dermo Cosmetique Association d’un extrait de myrte et d’un extrait de Tripterygium wilfordii pour lutter contre l’inflammation induite par C. acnes
WO2023066885A1 (en) 2021-10-19 2023-04-27 Glaxosmithkline Biologicals Sa Saponin production
FR3132632A1 (fr) * 2022-02-17 2023-08-18 Pierre Fabre Dermo-Cosmetique Composition comprenant un extrait de myrte et un extrait de Tripterygium wilfordii pour lutter contre l’acné des zones non lésionnelles de la peau acnéique
WO2023242187A1 (en) 2022-06-15 2023-12-21 Glaxosmithkline Biologicals Sa Enzymatic modification of saponins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101086642B1 (ko) * 2009-02-27 2011-11-24 강원대학교산학협력단 셀라스트롤을 유효성분으로 포함하는 알러지 질환 예방 및 치료용 조성물
FR2952072B1 (fr) * 2009-11-05 2013-09-27 Pf Medicament Procede de production de triptolide
CA2827583A1 (en) * 2011-03-01 2012-09-07 Phytomedics Corporation Inc. Methods of processing extracts of a t. wilfordii hook f. plant
CN103159822B (zh) * 2013-03-04 2016-05-18 华侨大学 雷公藤甲素及其衍生物组合物的制备方法

Also Published As

Publication number Publication date
EP3454875B1 (fr) 2020-09-23
WO2017194757A1 (fr) 2017-11-16
US20190134128A1 (en) 2019-05-09
FR3051116A1 (fr) 2017-11-17
BR112018073117B1 (pt) 2022-10-25
EP3454875A1 (fr) 2019-03-20
KR20190006523A (ko) 2019-01-18
SG11201809948XA (en) 2018-12-28
MX2018013728A (es) 2019-08-01
RU2743715C1 (ru) 2021-02-24
FR3051116B1 (fr) 2019-06-07
KR102513830B1 (ko) 2023-03-23
CA3023192A1 (fr) 2017-11-16
ES2831835T3 (es) 2021-06-09
PT3454875T (pt) 2020-12-11

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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