MX2018013728A - Metodo de produccion de celastrol y derivados de triterpeno pentaciclicos. - Google Patents
Metodo de produccion de celastrol y derivados de triterpeno pentaciclicos.Info
- Publication number
- MX2018013728A MX2018013728A MX2018013728A MX2018013728A MX2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A
- Authority
- MX
- Mexico
- Prior art keywords
- producing
- celastrol
- pentacyclic triterpene
- triterpene derivatives
- extract
- Prior art date
Links
- KQJSQWZMSAGSHN-UHFFFAOYSA-N (9beta,13alpha,14beta,20alpha)-3-hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid Natural products CC12CCC3(C)C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C2=CC=C2C1=CC(=O)C(O)=C2C KQJSQWZMSAGSHN-UHFFFAOYSA-N 0.000 title abstract 2
- AQKDBFWJOPNOKZ-UHFFFAOYSA-N Celastrol Natural products CC12CCC3(C)C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C2=CC=C2C1=CC(=O)C(=O)C2C AQKDBFWJOPNOKZ-UHFFFAOYSA-N 0.000 title abstract 2
- KQJSQWZMSAGSHN-JJWQIEBTSA-N celastrol Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)[C@](C)(C(O)=O)CC[C@]1(C)CC[C@]2(C)C4=CC=C1C3=CC(=O)C(O)=C1C KQJSQWZMSAGSHN-JJWQIEBTSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003648 triterpenes Chemical class 0.000 title abstract 2
- 239000000287 crude extract Substances 0.000 abstract 2
- 239000000284 extract Substances 0.000 abstract 2
- 241000208365 Celastraceae Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- -1 celastrol Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/11—Preparation or pretreatment of starting material involving culturing conditions, e.g. cultivation in the dark or under defined water stress
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Environmental Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un método para producir un extracto crudo enriquecido en triterpenos pentacíclicos, incluyendo celastrol, a partir de células de una planta de la familia Celastraceae; a un extracto crudo enriquecido que puede obtenerse usando tal método; a aplicaciones terapéuticas de tal extracto; y a composiciones farmacéuticas y dermocosméticas que contienen tal extracto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1654240A FR3051116B1 (fr) | 2016-05-12 | 2016-05-12 | Procede de production du celastrol et de derives triterpeniques pentacycliques |
| PCT/EP2017/061504 WO2017194757A1 (fr) | 2016-05-12 | 2017-05-12 | Procede de production du celastrol et de derives triterpeniques pentacycliques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018013728A true MX2018013728A (es) | 2019-08-01 |
Family
ID=56404155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018013728A MX2018013728A (es) | 2016-05-12 | 2017-05-12 | Metodo de produccion de celastrol y derivados de triterpeno pentaciclicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20190134128A1 (es) |
| EP (1) | EP3454875B1 (es) |
| KR (1) | KR102513830B1 (es) |
| BR (1) | BR112018073117B1 (es) |
| CA (1) | CA3023192A1 (es) |
| ES (1) | ES2831835T3 (es) |
| FR (1) | FR3051116B1 (es) |
| MX (1) | MX2018013728A (es) |
| PT (1) | PT3454875T (es) |
| RU (1) | RU2743715C1 (es) |
| SG (1) | SG11201809948XA (es) |
| WO (1) | WO2017194757A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3047665B1 (fr) * | 2016-02-17 | 2020-12-11 | Pf Medicament | Celastrol et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees |
| LU101117B1 (en) * | 2019-02-07 | 2020-08-07 | Luxembourg Institute Of Science And Tech (List) | METHOD FOR PRODUCING A COMPOSITION COMPRISING A 3-O-p-COUMAROYL ESTER OF TORMENTIC ACID FROM A PLANT CELL CULTURE, APPLICATIONS THEREOF AS ANTIPARASITIC AGENT FOR THE TREATMENT OF TRYPANOSOMIASIS |
| FR3095754B1 (fr) * | 2019-05-10 | 2021-11-19 | Fabre Pierre Dermo Cosmetique | Triterpènes pentacycliques dans le traitement du vitiligo |
| FR3120790B1 (fr) * | 2021-03-10 | 2024-03-15 | Fabre Pierre Dermo Cosmetique | Association d’un extrait de myrte et d’un extrait de Tripterygium wilfordii pour lutter contre l’inflammation induite par C. acnes |
| WO2023066885A1 (en) | 2021-10-19 | 2023-04-27 | Glaxosmithkline Biologicals Sa | Saponin production |
| FR3132632A1 (fr) * | 2022-02-17 | 2023-08-18 | Pierre Fabre Dermo-Cosmetique | Composition comprenant un extrait de myrte et un extrait de Tripterygium wilfordii pour lutter contre l’acné des zones non lésionnelles de la peau acnéique |
| WO2023242187A1 (en) | 2022-06-15 | 2023-12-21 | Glaxosmithkline Biologicals Sa | Enzymatic modification of saponins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101086642B1 (ko) * | 2009-02-27 | 2011-11-24 | 강원대학교산학협력단 | 셀라스트롤을 유효성분으로 포함하는 알러지 질환 예방 및 치료용 조성물 |
| FR2952072B1 (fr) * | 2009-11-05 | 2013-09-27 | Pf Medicament | Procede de production de triptolide |
| JP2014516338A (ja) * | 2011-03-01 | 2014-07-10 | フィトメディクス コーポレーション インコーポレーテッド | トリプテリジウム・ウィルフォルディ・フックｆ植物の抽出物を処理する方法 |
| CN103159822B (zh) * | 2013-03-04 | 2016-05-18 | 华侨大学 | 雷公藤甲素及其衍生物组合物的制备方法 |
-
2016
- 2016-05-12 FR FR1654240A patent/FR3051116B1/fr active Active
-
2017
- 2017-05-12 CA CA3023192A patent/CA3023192A1/fr active Pending
- 2017-05-12 EP EP17722071.2A patent/EP3454875B1/fr active Active
- 2017-05-12 ES ES17722071T patent/ES2831835T3/es active Active
- 2017-05-12 PT PT177220712T patent/PT3454875T/pt unknown
- 2017-05-12 US US16/099,952 patent/US20190134128A1/en not_active Abandoned
- 2017-05-12 SG SG11201809948XA patent/SG11201809948XA/en unknown
- 2017-05-12 KR KR1020187035725A patent/KR102513830B1/ko active IP Right Grant
- 2017-05-12 RU RU2018141358A patent/RU2743715C1/ru active
- 2017-05-12 BR BR112018073117-0A patent/BR112018073117B1/pt active IP Right Grant
- 2017-05-12 WO PCT/EP2017/061504 patent/WO2017194757A1/fr unknown
- 2017-05-12 MX MX2018013728A patent/MX2018013728A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR3051116A1 (fr) | 2017-11-17 |
| PT3454875T (pt) | 2020-12-11 |
| EP3454875A1 (fr) | 2019-03-20 |
| US20190134128A1 (en) | 2019-05-09 |
| SG11201809948XA (en) | 2018-12-28 |
| ES2831835T3 (es) | 2021-06-09 |
| BR112018073117B1 (pt) | 2022-10-25 |
| KR102513830B1 (ko) | 2023-03-23 |
| FR3051116B1 (fr) | 2019-06-07 |
| KR20190006523A (ko) | 2019-01-18 |
| EP3454875B1 (fr) | 2020-09-23 |
| RU2743715C1 (ru) | 2021-02-24 |
| CA3023192A1 (fr) | 2017-11-16 |
| BR112018073117A2 (pt) | 2019-03-06 |
| WO2017194757A1 (fr) | 2017-11-16 |
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